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355 related items for PubMed ID: 25513833

  • 1. Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.
    Goldfarb NE, Ohanessian M, Biswas S, McGee TD, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM.
    Biochemistry; 2015 Jan 20; 54(2):422-33. PubMed ID: 25513833
    [Abstract] [Full Text] [Related]

  • 2. Structural and kinetic analyses of the protease from an amprenavir-resistant human immunodeficiency virus type 1 mutant rendered resistant to saquinavir and resensitized to amprenavir.
    Markland W, Rao BG, Parsons JD, Black J, Zuchowski L, Tisdale M, Tung R.
    J Virol; 2000 Aug 20; 74(16):7636-41. PubMed ID: 10906218
    [Abstract] [Full Text] [Related]

  • 3. Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir.
    Prashar V, Bihani SC, Ferrer JL, Hosur MV.
    Chem Biol Drug Des; 2015 Sep 20; 86(3):302-8. PubMed ID: 25487655
    [Abstract] [Full Text] [Related]

  • 4. Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir.
    Kagan RM, Shenderovich MD, Heseltine PN, Ramnarayan K.
    Protein Sci; 2005 Jul 20; 14(7):1870-8. PubMed ID: 15937277
    [Abstract] [Full Text] [Related]

  • 5. Systematic molecular dynamics, MM-PBSA, and ab initio approaches to the saquinavir resistance mechanism in HIV-1 PR due to 11 double and multiple mutations.
    Tzoupis H, Leonis G, Avramopoulos A, Mavromoustakos T, Papadopoulos MG.
    J Phys Chem B; 2014 Aug 14; 118(32):9538-52. PubMed ID: 25036111
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance.
    Hong L, Zhang XC, Hartsuck JA, Tang J.
    Protein Sci; 2000 Oct 14; 9(10):1898-904. PubMed ID: 11106162
    [Abstract] [Full Text] [Related]

  • 7. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
    Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT.
    J Mol Biol; 2008 Aug 01; 381(1):102-15. PubMed ID: 18597780
    [Abstract] [Full Text] [Related]

  • 8. Predictive value of drug levels, HIV genotyping, and the genotypic inhibitory quotient (GIQ) on response to saquinavir/ritonavir in antiretroviral-experienced HIV-infected patients.
    Valer L, de Mendoza C, Soriano V.
    J Med Virol; 2005 Dec 01; 77(4):460-4. PubMed ID: 16254964
    [Abstract] [Full Text] [Related]

  • 9. A contribution to the drug resistance mechanism of darunavir, amprenavir, indinavir, and saquinavir complexes with HIV-1 protease due to flap mutation I50V: a systematic MM-PBSA and thermodynamic integration study.
    Leonis G, Steinbrecher T, Papadopoulos MG.
    J Chem Inf Model; 2013 Aug 26; 53(8):2141-53. PubMed ID: 23834142
    [Abstract] [Full Text] [Related]

  • 10. Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex.
    Prashar V, Bihani SC, Das A, Rao DR, Hosur MV.
    Biochem Biophys Res Commun; 2010 Jun 11; 396(4):1018-23. PubMed ID: 20471372
    [Abstract] [Full Text] [Related]

  • 11. Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance.
    Su CT, Ling WL, Lua WH, Haw YX, Gan SK.
    BMC Bioinformatics; 2016 Dec 22; 17(Suppl 19):500. PubMed ID: 28155724
    [Abstract] [Full Text] [Related]

  • 12. Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.
    Shen CH, Wang YF, Kovalevsky AY, Harrison RW, Weber IT.
    FEBS J; 2010 Sep 22; 277(18):3699-714. PubMed ID: 20695887
    [Abstract] [Full Text] [Related]

  • 13. Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis.
    Toor JS, Sharma A, Kumar R, Gupta P, Garg P, Arora SK.
    Antiviral Res; 2011 Nov 22; 92(2):213-8. PubMed ID: 21875619
    [Abstract] [Full Text] [Related]

  • 14. Insights into a mutation-assisted lateral drug escape mechanism from the HIV-1 protease active site.
    Sadiq SK, Wan S, Coveney PV.
    Biochemistry; 2007 Dec 25; 46(51):14865-77. PubMed ID: 18052195
    [Abstract] [Full Text] [Related]

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  • 17. Drug Resistance Mechanism of M46I-Mutation-Induced Saquinavir Resistance in HIV-1 Protease Using Molecular Dynamics Simulation and Binding Energy Calculation.
    Rana N, Singh AK, Shuaib M, Gupta S, Habiballah MM, Alkhanani MF, Haque S, Reshi MS, Kumar S.
    Viruses; 2022 Mar 28; 14(4):. PubMed ID: 35458427
    [Abstract] [Full Text] [Related]

  • 18. Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
    Tie Y, Wang YF, Boross PI, Chiu TY, Ghosh AK, Tozser J, Louis JM, Harrison RW, Weber IT.
    Protein Sci; 2012 Mar 28; 21(3):339-50. PubMed ID: 22238126
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  • 20. Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
    Lockbaum GJ, Leidner F, Rusere LN, Henes M, Kosovrasti K, Nachum GS, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA.
    ACS Infect Dis; 2019 Feb 08; 5(2):316-325. PubMed ID: 30543749
    [Abstract] [Full Text] [Related]

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