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Journal Abstract Search

198 related items for PubMed ID: 2552074

  • 1. Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig.
    Harris AL, Connell MJ, Ferguson EW, Wallace AM, Gordon RJ, Pagani ED, Silver PJ.
    J Pharmacol Exp Ther; 1989 Oct; 251(1):199-206. PubMed ID: 2552074
    [Abstract] [Full Text] [Related]

  • 2. Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside.
    Turner NC, Lamb J, Worby A, Murray KJ.
    Br J Pharmacol; 1994 Apr; 111(4):1047-52. PubMed ID: 8032589
    [Abstract] [Full Text] [Related]

  • 3. Modulation of relaxant responses evoked by a nitric oxide donor and by nonadrenergic, noncholinergic stimulation by isozyme-selective phosphodiesterase inhibitors in guinea pig trachea.
    Ellis JL, Conanan ND.
    J Pharmacol Exp Ther; 1995 Mar; 272(3):997-1004. PubMed ID: 7891355
    [Abstract] [Full Text] [Related]

  • 4. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.
    Underwood DC, Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann MA, Hay DW, Torphy TJ.
    J Pharmacol Exp Ther; 1994 Jul; 270(1):250-9. PubMed ID: 8035322
    [Abstract] [Full Text] [Related]

  • 5. Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone.
    Souness JE, Villamil ME, Scott LC, Tomkinson A, Giembycz MA, Raeburn D.
    Br J Pharmacol; 1994 Apr; 111(4):1081-8. PubMed ID: 8032594
    [Abstract] [Full Text] [Related]

  • 6. The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.
    Barnette MS, Manning CD, Cieslinski LB, Burman M, Christensen SB, Torphy TJ.
    J Pharmacol Exp Ther; 1995 May; 273(2):674-9. PubMed ID: 7752069
    [Abstract] [Full Text] [Related]

  • 7. Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle.
    Torphy TJ, Undem BJ, Cieslinski LB, Luttmann MA, Reeves ML, Hay DW.
    J Pharmacol Exp Ther; 1993 Jun; 265(3):1213-23. PubMed ID: 8389856
    [Abstract] [Full Text] [Related]

  • 8. Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor.
    Wright KF, Turner CR, Jayasinghe-Beck R, Cohen VL, Cheng JB, Watson JW.
    Can J Physiol Pharmacol; 1997 Aug; 75(8):1001-8. PubMed ID: 9360015
    [Abstract] [Full Text] [Related]

  • 9. Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641.
    Heaslip RJ, Lombardo LJ, Golankiewicz JM, Ilsemann BA, Evans DY, Sickels BD, Mudrick JK, Bagli J, Weichman BM.
    J Pharmacol Exp Ther; 1994 Feb; 268(2):888-96. PubMed ID: 8114002
    [Abstract] [Full Text] [Related]

  • 10. CDP840: a novel inhibitor of PDE-4.
    Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ.
    Cell Biochem Biophys; 1998 Feb; 29(1-2):113-32. PubMed ID: 9631241
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.
    Barnette MS, Grous M, Cieslinski LB, Burman M, Christensen SB, Torphy TJ.
    J Pharmacol Exp Ther; 1995 Jun; 273(3):1396-402. PubMed ID: 7791113
    [Abstract] [Full Text] [Related]

  • 12. Characterization of ORG 20241, a combined phosphodiesterase IV/III cyclic nucleotide phosphodiesterase inhibitor for asthma.
    Nicholson CD, Shahid M, Bruin J, Barron E, Spiers I, de Boer J, van Amsterdam RG, Zaagsma J, Kelly JJ, Dent G.
    J Pharmacol Exp Ther; 1995 Aug; 274(2):678-87. PubMed ID: 7636728
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor.
    Holbrook M, Gozzard N, James T, Higgs G, Hughes B.
    Br J Pharmacol; 1996 Jul; 118(5):1192-200. PubMed ID: 8818343
    [Abstract] [Full Text] [Related]

  • 14. Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.
    Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW.
    J Med Chem; 1996 Jan 05; 39(1):120-5. PubMed ID: 8568798
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.
    Underwood DC, Osborn RR, Novak LB, Matthews JK, Newsholme SJ, Undem BJ, Hand JM, Torphy TJ.
    J Pharmacol Exp Ther; 1993 Jul 05; 266(1):306-13. PubMed ID: 8392555
    [Abstract] [Full Text] [Related]

  • 16. Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors.
    Kelly JJ, Barnes PJ, Giembycz MA.
    Br J Pharmacol; 1998 May 05; 124(1):129-40. PubMed ID: 9630352
    [Abstract] [Full Text] [Related]

  • 17. Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors.
    Willette RN, Shiloh AO, Sauermelch CF, Sulpizio A, Michell MP, Cieslinski LB, Torphy TJ, Ohlstein EH.
    J Cereb Blood Flow Metab; 1997 Feb 05; 17(2):210-9. PubMed ID: 9040501
    [Abstract] [Full Text] [Related]

  • 18. Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.
    Tian G, Rocque WJ, Wiseman JS, Thompson IZ, Holmes WD, Domanico PL, Stafford JA, Feldman PL, Luther MA.
    Biochemistry; 1998 May 12; 37(19):6894-904. PubMed ID: 9578576
    [Abstract] [Full Text] [Related]

  • 19. Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor.
    Collado MC, Beleta J, Martinez E, Miralpeix M, Domènech T, Palacios JM, Hernández J.
    Br J Pharmacol; 1998 Mar 12; 123(6):1047-54. PubMed ID: 9559885
    [Abstract] [Full Text] [Related]

  • 20. Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.
    Howell RE, Sickels BD, Woeppel SL.
    J Pharmacol Exp Ther; 1993 Feb 12; 264(2):609-15. PubMed ID: 8437112
    [Abstract] [Full Text] [Related]

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