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221 related items for PubMed ID: 25543140

  • 1. HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
    Vaughan L, Tan CT, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF, Malliri A.
    Cell Rep; 2015 Jan 06; 10(1):88-102. PubMed ID: 25543140
    [Abstract] [Full Text] [Related]

  • 2. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.
    Malliri A, van Es S, Huveneers S, Collard JG.
    J Biol Chem; 2004 Jul 16; 279(29):30092-8. PubMed ID: 15138270
    [Abstract] [Full Text] [Related]

  • 3. Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression.
    Engers R, Springer E, Michiels F, Collard JG, Gabbert HE.
    J Biol Chem; 2001 Nov 09; 276(45):41889-97. PubMed ID: 11551917
    [Abstract] [Full Text] [Related]

  • 4. Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.
    Adams HC, Chen R, Liu Z, Whitehead IP.
    Breast Cancer Res; 2010 Nov 09; 12(5):R69. PubMed ID: 20819206
    [Abstract] [Full Text] [Related]

  • 5. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
    Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.
    Cancer Cell; 2017 May 08; 31(5):621-634.e6. PubMed ID: 28416184
    [Abstract] [Full Text] [Related]

  • 6. The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
    Minard ME, Kim LS, Price JE, Gallick GE.
    Breast Cancer Res Treat; 2004 Mar 08; 84(1):21-32. PubMed ID: 14999151
    [Abstract] [Full Text] [Related]

  • 7. The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.
    Boissier P, Huynh-Do U.
    Cell Signal; 2014 Mar 08; 26(3):483-91. PubMed ID: 24308970
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.
    Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC, Collard JG.
    Science; 1997 Nov 21; 278(5342):1464-6. PubMed ID: 9367959
    [Abstract] [Full Text] [Related]

  • 9. miR-10b targets Tiam1: implications for Rac activation and carcinoma migration.
    Moriarty CH, Pursell B, Mercurio AM.
    J Biol Chem; 2010 Jul 02; 285(27):20541-6. PubMed ID: 20444703
    [Abstract] [Full Text] [Related]

  • 10. Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
    Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D.
    J Biol Chem; 2014 Oct 03; 289(40):27400-9. PubMed ID: 25124033
    [Abstract] [Full Text] [Related]

  • 11. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).
    Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ.
    J Biol Chem; 2010 Jun 04; 285(23):18060-71. PubMed ID: 20360004
    [Abstract] [Full Text] [Related]

  • 12. MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma.
    Liu N, Tang LL, Sun Y, Cui RX, Wang HY, Huang BJ, He QM, Jiang W, Ma J.
    Cancer Lett; 2013 Feb 28; 329(2):181-8. PubMed ID: 23142282
    [Abstract] [Full Text] [Related]

  • 13. Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement.
    Higginbotham K, Tian Y, Gawlak G, Moldobaeva N, Shah A, Birukova AA.
    Cell Signal; 2014 Nov 28; 26(11):2306-16. PubMed ID: 25101856
    [Abstract] [Full Text] [Related]

  • 14. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.
    Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F, Collard JG.
    J Cell Biol; 1998 Nov 30; 143(5):1385-98. PubMed ID: 9832565
    [Abstract] [Full Text] [Related]

  • 15. Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.
    Van Leeuwen FN, Olivo C, Grivell S, Giepmans BN, Collard JG, Moolenaar WH.
    J Biol Chem; 2003 Jan 03; 278(1):400-6. PubMed ID: 12393875
    [Abstract] [Full Text] [Related]

  • 16. Antisense Tiam1 down-regulates the invasiveness of 95D cells in vitro.
    Hou M, Tan L, Wang X, Zhu YS.
    Acta Biochim Biophys Sin (Shanghai); 2004 Aug 03; 36(8):537-40. PubMed ID: 15295645
    [Abstract] [Full Text] [Related]

  • 17. The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
    Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG.
    J Biol Chem; 2006 Jan 06; 281(1):543-8. PubMed ID: 16249175
    [Abstract] [Full Text] [Related]

  • 18. SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.
    Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG, Malliri A.
    Mol Cell; 2009 Mar 13; 33(5):639-53. PubMed ID: 19285946
    [Abstract] [Full Text] [Related]

  • 19. Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation.
    Cruz-Monserrate Z, O'Connor KL.
    Neoplasia; 2008 May 13; 10(5):408-17. PubMed ID: 18472958
    [Abstract] [Full Text] [Related]

  • 20. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.
    Whalley HJ, Porter AP, Diamantopoulou Z, White GR, Castañeda-Saucedo E, Malliri A.
    Nat Commun; 2015 Jun 16; 6():7437. PubMed ID: 26078008
    [Abstract] [Full Text] [Related]


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