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137 related items for PubMed ID: 25563361

  • 1. KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.
    Yu CC, Liu SP, Hsu JL, Hsu JT, Kudryavtsev KV, Guh JH.
    J Biomed Sci; 2015 Jan 07; 22(1):2. PubMed ID: 25563361
    [Abstract] [Full Text] [Related]

  • 2. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
    Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH.
    Biochem Pharmacol; 2007 Jun 30; 74(1):10-9. PubMed ID: 17475221
    [Abstract] [Full Text] [Related]

  • 3. Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway.
    Ho CH, Hsu JL, Liu SP, Hsu LC, Chang WL, Chao CC, Guh JH.
    Prostate; 2015 Sep 30; 75(13):1454-66. PubMed ID: 26180030
    [Abstract] [Full Text] [Related]

  • 4. The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
    Chang LC, Yu YL, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC.
    Cancer Chemother Pharmacol; 2015 Jun 30; 75(6):1303-15. PubMed ID: 25947085
    [Abstract] [Full Text] [Related]

  • 5. MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
    Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC, Chung JG.
    J Pharmacol Exp Ther; 2010 Aug 30; 334(2):477-88. PubMed ID: 20463006
    [Abstract] [Full Text] [Related]

  • 6. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
    Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2006 Dec 30; 374(3):223-33. PubMed ID: 17102938
    [Abstract] [Full Text] [Related]

  • 7. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.
    Chen CH, Liao CH, Chang YL, Guh JH, Pan SL, Teng CM.
    Cancer Lett; 2012 Feb 01; 315(1):1-11. PubMed ID: 22033245
    [Abstract] [Full Text] [Related]

  • 8. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
    Chang WL, Chang CS, Chiang PC, Ho YF, Liu JF, Chang KW, Guh JH.
    Br J Pharmacol; 2010 Aug 01; 160(7):1677-89. PubMed ID: 20649571
    [Abstract] [Full Text] [Related]

  • 9. Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.
    Chang WL, Yu CC, Chen CS, Guh JH.
    Biochem Pharmacol; 2015 Mar 01; 94(1):12-21. PubMed ID: 25615907
    [Abstract] [Full Text] [Related]

  • 10. CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.
    Huang YT, Huang DM, Guh JH, Chen IL, Tzeng CC, Teng CM.
    J Biol Chem; 2005 Jan 28; 280(4):2771-9. PubMed ID: 15536083
    [Abstract] [Full Text] [Related]

  • 11. Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
    Hsiao CJ, Ho YF, Hsu JT, Chang WL, Chen YC, Shen YC, Lyu PC, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2008 Dec 28; 378(6):599-608. PubMed ID: 18663430
    [Abstract] [Full Text] [Related]

  • 12. Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
    Chan ML, Liang JW, Hsu LC, Chang WL, Lee SS, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2015 Nov 28; 388(11):1223-36. PubMed ID: 26246051
    [Abstract] [Full Text] [Related]

  • 13. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
    Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2010 Dec 28; 24(6):1499-507. PubMed ID: 21042745
    [Abstract] [Full Text] [Related]

  • 14. MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.
    Pai HC, Kumar S, Shen CC, Liou JP, Pan SL, Teng CM.
    PLoS One; 2015 Dec 28; 10(4):e0123819. PubMed ID: 25874627
    [Abstract] [Full Text] [Related]

  • 15. Dependency of 2-methoxyestradiol-induced mitochondrial apoptosis on mitotic spindle network impairment and prometaphase arrest in human Jurkat T cells.
    Lee ST, Lee JY, Han CR, Kim YH, Jun do Y, Taub D, Kim YH.
    Biochem Pharmacol; 2015 Apr 15; 94(4):257-69. PubMed ID: 25732194
    [Abstract] [Full Text] [Related]

  • 16. Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.
    Viola G, Cecconet L, Leszl A, Basso G, Brun P, Salvador A, Dall'Acqua F, Diana P, Barraja P, Cirrincione G.
    Cancer Chemother Pharmacol; 2009 Nov 15; 64(6):1235-51. PubMed ID: 19363609
    [Abstract] [Full Text] [Related]

  • 17. 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway.
    Torres F, Quintana J, Estévez F.
    Mol Carcinog; 2011 Feb 15; 50(2):113-22. PubMed ID: 21229608
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.
    Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.
    Bioorg Med Chem; 2014 May 01; 22(9):2714-23. PubMed ID: 24721832
    [Abstract] [Full Text] [Related]

  • 19. CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents.
    Zhou L, Cai X, Han X, Xu N, Chang DC.
    Cell Biol Int; 2014 Jun 01; 38(6):737-46. PubMed ID: 24677263
    [Abstract] [Full Text] [Related]

  • 20. Anticancer activity of a novel small molecule tubulin inhibitor STK899704.
    Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY.
    PLoS One; 2017 Jun 01; 12(3):e0173311. PubMed ID: 28296906
    [Abstract] [Full Text] [Related]

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