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Journal Abstract Search

225 related items for PubMed ID: 25596744

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  • 4. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.
    Menges CW, Sementino E, Talarchek J, Xu J, Chernoff J, Peterson JR, Testa JR.
    Mol Cancer Res; 2012 Sep; 10(9):1178-88. PubMed ID: 22798428
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  • 6. An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.
    Stepanova DS, Semenova G, Kuo YM, Andrews AJ, Ammoun S, Hanemann CO, Chernoff J.
    Cancer Res; 2017 Sep 15; 77(18):5026-5038. PubMed ID: 28729415
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  • 8. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.
    Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A.
    Neoplasia; 2008 Nov 15; 10(11):1204-12. PubMed ID: 18953429
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  • 9. Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types.
    James MF, Stivison E, Beauchamp R, Han S, Li H, Wallace MR, Gusella JF, Stemmer-Rachamimov AO, Ramesh V.
    Mol Cancer Res; 2012 May 15; 10(5):649-59. PubMed ID: 22426462
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  • 10. Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.
    Burns SS, Akhmametyeva EM, Oblinger JL, Bush ML, Huang J, Senner V, Chen CS, Jacob A, Welling DB, Chang LS.
    Cancer Res; 2013 Jan 15; 73(2):792-803. PubMed ID: 23151902
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  • 11. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.
    Beauchamp RL, James MF, DeSouza PA, Wagh V, Zhao WN, Jordan JT, Stemmer-Rachamimov A, Plotkin SR, Gusella JF, Haggarty SJ, Ramesh V.
    Oncotarget; 2015 Jul 10; 6(19):16981-97. PubMed ID: 26219339
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  • 15. NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
    James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.
    Mol Cell Biol; 2009 Aug 10; 29(15):4250-61. PubMed ID: 19451225
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  • 17. Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
    Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW, Synodos for NF2 Consortium.
    PLoS One; 2021 Aug 10; 16(7):e0252048. PubMed ID: 34264955
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  • 19. NF2/Merlin suppresses proliferation and induces apoptosis in colorectal cancer cells.
    Wu X, Mao F, Li N, Li W, Luo Y, Shi W, Ren J.
    Front Biosci (Landmark Ed); 2020 Jan 01; 25(3):513-525. PubMed ID: 31585900
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  • 20. PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
    Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ.
    Hum Mol Genet; 2021 Aug 12; 30(17):1607-1617. PubMed ID: 34075397
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