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Journal Abstract Search

420 related items for PubMed ID: 25597007

  • 1. Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
    Digiacomo M, Chen Z, Wang S, Lapucci A, Macchia M, Yang X, Chu J, Han Y, Pi R, Rapposelli S.
    Bioorg Med Chem Lett; 2015 Feb 15; 25(4):807-10. PubMed ID: 25597007
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
    Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, Pi R.
    Bioorg Med Chem Lett; 2012 Oct 15; 22(20):6498-502. PubMed ID: 22981331
    [Abstract] [Full Text] [Related]

  • 3. New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
    Fernández-Bachiller MI, Pérez C, Monjas L, Rademann J, Rodríguez-Franco MI.
    J Med Chem; 2012 Feb 09; 55(3):1303-17. PubMed ID: 22243648
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
    Keri RS, Quintanova C, Marques SM, Esteves AR, Cardoso SM, Santos MA.
    Bioorg Med Chem; 2013 Aug 01; 21(15):4559-69. PubMed ID: 23768661
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
    Zhu J, Yang H, Chen Y, Lin H, Li Q, Mo J, Bian Y, Pei Y, Sun H.
    J Enzyme Inhib Med Chem; 2018 Dec 01; 33(1):496-506. PubMed ID: 29405075
    [Abstract] [Full Text] [Related]

  • 6. Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease.
    Fu Y, Mu Y, Lei H, Wang P, Li X, Leng Q, Han L, Qu X, Wang Z, Huang X.
    Molecules; 2016 Oct 11; 21(10):. PubMed ID: 27727187
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
    Luo W, Li YP, He Y, Huang SL, Li D, Gu LQ, Huang ZS.
    Eur J Med Chem; 2011 Jun 11; 46(6):2609-16. PubMed ID: 21497959
    [Abstract] [Full Text] [Related]

  • 8. Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
    Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, López MG, Wehle S, Gharbi T, Refouvelet B, de Andrés L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodríguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L.
    ChemMedChem; 2015 Mar 11; 10(3):523-39. PubMed ID: 25537267
    [Abstract] [Full Text] [Related]

  • 9. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
    Sun Q, Peng DY, Yang SG, Zhu XL, Yang WC, Yang GF.
    Bioorg Med Chem; 2014 Sep 01; 22(17):4784-91. PubMed ID: 25088549
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.
    Bioorg Med Chem; 2014 Nov 01; 22(21):6089-104. PubMed ID: 25282654
    [Abstract] [Full Text] [Related]

  • 11. Tacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease.
    Chen Y, Sun J, Peng S, Liao H, Zhang Y, Lehmann J.
    Arch Pharm (Weinheim); 2013 Dec 01; 346(12):865-71. PubMed ID: 24203864
    [Abstract] [Full Text] [Related]

  • 12. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
    Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2905-9. PubMed ID: 18406135
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
    Thiratmatrakul S, Yenjai C, Waiwut P, Vajragupta O, Reubroycharoen P, Tohda M, Boonyarat C.
    Eur J Med Chem; 2014 Mar 21; 75():21-30. PubMed ID: 24508831
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.
    Riazimontazer E, Sadeghpour H, Nadri H, Sakhteman A, Tüylü Küçükkılınç T, Miri R, Edraki N.
    Bioorg Chem; 2019 Aug 21; 89():103006. PubMed ID: 31158577
    [Abstract] [Full Text] [Related]

  • 15. Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
    Bolognesi ML, Bartolini M, Mancini F, Chiriano G, Ceccarini L, Rosini M, Milelli A, Tumiatti V, Andrisano V, Melchiorre C.
    ChemMedChem; 2010 Aug 02; 5(8):1215-20. PubMed ID: 20486153
    [No Abstract] [Full Text] [Related]

  • 16. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
    Liao S, Deng H, Huang S, Yang J, Wang S, Yin B, Zheng T, Zhang D, Liu J, Gao G, Ma J, Deng Z.
    Bioorg Med Chem Lett; 2015 Apr 01; 25(7):1541-5. PubMed ID: 25724825
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS, Wang XB, Li JY, Yang L, Kong LY.
    Eur J Med Chem; 2013 Jun 01; 64():540-53. PubMed ID: 23685572
    [Abstract] [Full Text] [Related]

  • 18. Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
    Fernández-Bachiller MI, Pérez C, González-Muñoz GC, Conde S, López MG, Villarroya M, García AG, Rodríguez-Franco MI.
    J Med Chem; 2010 Jul 08; 53(13):4927-37. PubMed ID: 20545360
    [Abstract] [Full Text] [Related]

  • 19. Rational approach to discover multipotent anti-Alzheimer drugs.
    Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C.
    J Med Chem; 2005 Jan 27; 48(2):360-3. PubMed ID: 15658850
    [Abstract] [Full Text] [Related]

  • 20. O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
    Mao F, Huang L, Luo Z, Liu A, Lu C, Xie Z, Li X.
    Bioorg Med Chem; 2012 Oct 01; 20(19):5884-92. PubMed ID: 22944335
    [Abstract] [Full Text] [Related]

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