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498 related items for PubMed ID: 25665755

  • 1. The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats.
    Tan X, Chen Y, Li J, Li X, Miao Z, Xin N, Zhu J, Ge W, Feng Y, Xu X.
    Neuroscience; 2015 Apr 02; 290():552-60. PubMed ID: 25665755
    [Abstract] [Full Text] [Related]

  • 2. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
    Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC.
    J Biol Chem; 2010 Oct 29; 285(44):34202-12. PubMed ID: 20720012
    [Abstract] [Full Text] [Related]

  • 3. Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.
    Sun LH, Ban T, Liu CD, Chen QX, Wang X, Yan ML, Hu XL, Su XL, Bao YN, Sun LL, Zhao LJ, Pei SC, Jiang XM, Zong DK, Ai J.
    J Neurochem; 2015 Sep 29; 134(6):1139-51. PubMed ID: 26118667
    [Abstract] [Full Text] [Related]

  • 4. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model.
    Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul NB, Han S, Yin J, Liu WH, He XH, Peng BW.
    Neuropharmacology; 2015 Dec 29; 99():38-50. PubMed ID: 26187393
    [Abstract] [Full Text] [Related]

  • 5. Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein.
    Binukumar BK, Shukla V, Amin ND, Bhaskar M, Skuntz S, Steiner J, Winkler D, Pelech SL, Pant HC.
    J Alzheimers Dis; 2015 Dec 29; 48(4):1009-17. PubMed ID: 26444778
    [Abstract] [Full Text] [Related]

  • 6. TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury.
    Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, Turlova E, Barszczyk A, Zhong X, Sun CL, Britto LR, Feng ZP, Sun HS.
    Mol Brain; 2015 Feb 19; 8():11. PubMed ID: 25761704
    [Abstract] [Full Text] [Related]

  • 7. Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain.
    Ramos-Miguel A, García-Sevilla JA.
    Neuroscience; 2012 Jul 26; 215():17-30. PubMed ID: 22537847
    [Abstract] [Full Text] [Related]

  • 8. Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.
    Binukumar BK, Pelech SL, Sutter C, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC.
    J Alzheimers Dis; 2016 Sep 06; 54(2):525-33. PubMed ID: 27567857
    [Abstract] [Full Text] [Related]

  • 9. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.
    Nath R, Davis M, Probert AW, Kupina NC, Ren X, Schielke GP, Wang KK.
    Biochem Biophys Res Commun; 2000 Jul 21; 274(1):16-21. PubMed ID: 10903889
    [Abstract] [Full Text] [Related]

  • 10. The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.
    Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.
    Biochem Biophys Res Commun; 2001 Feb 02; 280(4):998-1002. PubMed ID: 11162625
    [Abstract] [Full Text] [Related]

  • 11. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury.
    Yousuf MA, Tan C, Torres-Altoro MI, Lu FM, Plautz E, Zhang S, Takahashi M, Hernandez A, Kernie SG, Plattner F, Bibb JA.
    J Neurochem; 2016 Jul 02; 138(2):317-27. PubMed ID: 26998748
    [Abstract] [Full Text] [Related]

  • 12. GSK-3β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.
    Huang S, Wang H, Turlova E, Abussaud A, Ji X, Britto LR, Miller SP, Martinez A, Sun HS, Feng ZP.
    CNS Neurosci Ther; 2017 May 02; 23(5):405-415. PubMed ID: 28256059
    [Abstract] [Full Text] [Related]

  • 13. The role of CDK5/P25 formation/inhibition in neurodegeneration.
    Camins A, Verdaguer E, Folch J, Canudas AM, Pallàs M.
    Drug News Perspect; 2006 Oct 02; 19(8):453-60. PubMed ID: 17160145
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury.
    Nijboer CH, van der Kooij MA, van Bel F, Ohl F, Heijnen CJ, Kavelaars A.
    Brain Behav Immun; 2010 Jul 02; 24(5):812-21. PubMed ID: 19766183
    [Abstract] [Full Text] [Related]

  • 15. The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.
    Hisanaga S, Saito T.
    Neurosignals; 2003 Jul 02; 12(4-5):221-9. PubMed ID: 14673209
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
    Barros-Miñones L, Martín-de-Saavedra D, Perez-Alvarez S, Orejana L, Suquía V, Goñi-Allo B, Hervias I, López MG, Jordan J, Aguirre N, Puerta E.
    Biochim Biophys Acta; 2013 Jun 02; 1832(6):705-17. PubMed ID: 23415811
    [Abstract] [Full Text] [Related]

  • 17. Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.
    Kesavapany S, Zheng YL, Amin N, Pant HC.
    Biotechnol J; 2007 Aug 02; 2(8):978-87. PubMed ID: 17526058
    [Abstract] [Full Text] [Related]

  • 18. TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke.
    Ji YB, Zhuang PP, Ji Z, Wu YM, Gu Y, Gao XY, Pan SY, Hu YF.
    Sci Rep; 2017 Jan 03; 7():40013. PubMed ID: 28045138
    [Abstract] [Full Text] [Related]

  • 19. Dexamethasone-induced neuroprotection in hypoxic-ischemic brain injury in newborn rats is partly mediated via Akt activation.
    Feng Y, Lu S, Wang J, Kumar P, Zhang L, Bhatt AJ.
    Brain Res; 2014 Nov 17; 1589():68-77. PubMed ID: 25304361
    [Abstract] [Full Text] [Related]

  • 20. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.
    Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH.
    Nature; 1999 Dec 09; 402(6762):615-22. PubMed ID: 10604467
    [Abstract] [Full Text] [Related]

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