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182 related items for PubMed ID: 25690564

  • 1. Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors.
    Dadashpour S, Tuylu Kucukkilinc T, Unsal Tan O, Ozadali K, Irannejad H, Emami S.
    Arch Pharm (Weinheim); 2015 Mar; 348(3):179-87. PubMed ID: 25690564
    [Abstract] [Full Text] [Related]

  • 2. 1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and β-amyloid aggregation inhibitors: biological evaluation and in silico study.
    Irannejad H, Unsal Tan O, Ozadali K, Dadashpour S, Tuylu Kucukkilinc T, Ahangar N, Ahmadnejad M, Emami S.
    Chem Biol Drug Des; 2015 Apr; 85(4):494-503. PubMed ID: 25227162
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.
    Irannejad H, Kebriaieezadeh A, Zarghi A, Montazer-Sadegh F, Shafiee A, Assadieskandar A, Amini M.
    Bioorg Med Chem; 2014 Jan 15; 22(2):865-73. PubMed ID: 24361187
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.
    Consalvi S, Alfonso S, Di Capua A, Poce G, Pirolli A, Sabatino M, Ragno R, Anzini M, Sartini S, La Motta C, Di Cesare Mannelli L, Ghelardini C, Biava M.
    Bioorg Med Chem; 2015 Feb 15; 23(4):810-20. PubMed ID: 25596758
    [Abstract] [Full Text] [Related]

  • 5. Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.
    Szałaj N, Bajda M, Dudek K, Brus B, Gobec S, Malawska B.
    Arch Pharm (Weinheim); 2015 Aug 15; 348(8):556-63. PubMed ID: 26032855
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.
    Bioorg Med Chem; 2014 Nov 01; 22(21):6089-104. PubMed ID: 25282654
    [Abstract] [Full Text] [Related]

  • 7. Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.
    Huang M, Xie SS, Jiang N, Lan JS, Kong LY, Wang XB.
    Bioorg Med Chem Lett; 2015 Feb 01; 25(3):508-13. PubMed ID: 25542589
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
    Elshemy HAH, Abdelall EKA, Azouz AA, Moawad A, Ali WAM, Safwat NM.
    Eur J Med Chem; 2017 Feb 15; 127():10-21. PubMed ID: 28038322
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
    Banerjee AG, Das N, Shengule SA, Sharma PA, Srivastava RS, Shrivastava SK.
    Bioorg Chem; 2016 Dec 15; 69():102-120. PubMed ID: 27750057
    [Abstract] [Full Text] [Related]

  • 10. Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities.
    Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, Nadri H, Moradi A, Shafiee A, Miri R.
    J Enzyme Inhib Med Chem; 2016 Dec 15; 31(6):1602-11. PubMed ID: 27028154
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
    Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B.
    Eur J Med Chem; 2017 Jan 05; 125():676-695. PubMed ID: 27721153
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.
    Alegaon SG, Hirpara MB, Alagawadi KR, Hullatti KK, Kashniyal K.
    Bioorg Med Chem Lett; 2014 Nov 15; 24(22):5324-9. PubMed ID: 25444084
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease.
    Iraji A, Firuzi O, Khoshneviszadeh M, Nadri H, Edraki N, Miri R.
    Bioorg Chem; 2018 Apr 15; 77():223-235. PubMed ID: 29367079
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors.
    Jiang B, Zeng Y, Li MJ, Xu JY, Zhang YN, Wang QJ, Sun NY, Lu T, Wu XM.
    Arch Pharm (Weinheim); 2010 Sep 15; 343(9):500-8. PubMed ID: 20842641
    [Abstract] [Full Text] [Related]

  • 15. Trimethyl-4-oxo-4,5,6,7-tetrahydroindazole-1-acetic acid: a new lead compound with selective COX-2 inhibitory activity.
    Abdel-Rahman HM, Ozadali K.
    Arch Pharm (Weinheim); 2012 Nov 15; 345(11):878-83. PubMed ID: 22907715
    [Abstract] [Full Text] [Related]

  • 16. Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.
    Mohamed LW, El-Badry OM, El-Ansary AK, Ismael A.
    Bioorg Chem; 2017 Jun 15; 72():308-314. PubMed ID: 28500957
    [Abstract] [Full Text] [Related]

  • 17. [Studies on as-triazine derivatives. XVIII. Synthesis of 5,6-diaryl-1,2,4-triazine derivatives as blood platelet aggregation inhibitors].
    Konno S, Kokubo T, Amano M, Yoshida N, Sagi M, Yamanaka H.
    Yakugaku Zasshi; 1992 Oct 15; 112(10):729-41. PubMed ID: 1469603
    [Abstract] [Full Text] [Related]

  • 18. Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
    Larbanoix L, Burtea C, Ansciaux E, Laurent S, Mahieu I, Vander Elst L, Muller RN.
    Peptides; 2011 Jun 15; 32(6):1232-43. PubMed ID: 21575663
    [Abstract] [Full Text] [Related]

  • 19. Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
    Biava M, Porretta GC, Poce G, Supino S, Forli S, Rovini M, Cappelli A, Manetti F, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Vivoli E, Makovec F, Anzellotti P, Patrignani P, Anzini M.
    J Med Chem; 2007 Nov 01; 50(22):5403-11. PubMed ID: 17915854
    [Abstract] [Full Text] [Related]

  • 20. Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors.
    Wang G, Peng Z, Wang J, Li X, Li J.
    Eur J Med Chem; 2017 Jan 05; 125():423-429. PubMed ID: 27689725
    [Abstract] [Full Text] [Related]

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