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283 related items for PubMed ID: 25692341

  • 1. Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.
    Raimondo A, Rees MG, Gloyn AL.
    Curr Opin Lipidol; 2015 Apr; 26(2):88-95. PubMed ID: 25692341
    [Abstract] [Full Text] [Related]

  • 2. Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes.
    Paliwal A, Paliwal V, Jain S, Paliwal S, Sharma S.
    Mini Rev Med Chem; 2024 Apr; 24(7):674-688. PubMed ID: 37612862
    [Abstract] [Full Text] [Related]

  • 3. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
    Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, Gloyn AL.
    Hum Mol Genet; 2009 Nov 01; 18(21):4081-8. PubMed ID: 19643913
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  • 4. Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.
    Rees MG, Wincovitch S, Schultz J, Waterstradt R, Beer NL, Baltrusch S, Collins FS, Gloyn AL.
    Diabetologia; 2012 Jan 01; 55(1):114-22. PubMed ID: 22038520
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  • 5. The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.
    Ford BE, Chachra SS, Rodgers K, Moonira T, Al-Oanzi ZH, Anstee QM, Reeves HL, Schattenberg JM, Fairclough RJ, Smith DM, Tiniakos D, Agius L.
    Mol Metab; 2023 Jun 01; 72():101722. PubMed ID: 37031802
    [Abstract] [Full Text] [Related]

  • 6. Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD.
    Zhang Z, Ji G, Li M.
    Front Endocrinol (Lausanne); 2023 Jun 01; 14():1247611. PubMed ID: 37711901
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  • 7. Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study.
    Wang K, Shi M, Luk AOY, Kong APS, Ma RCW, Li C, Chen L, Chow E, Chan JCN.
    Cardiovasc Diabetol; 2024 Jun 29; 23(1):228. PubMed ID: 38951793
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  • 10. Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver.
    Hiskett EK, Suwitheechon OU, Lindbloom-Hawley S, Boyle DL, Schermerhorn T.
    Vet Res Commun; 2009 Mar 29; 33(3):227-40. PubMed ID: 18780155
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  • 11. Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.
    Rees MG, Ng D, Ruppert S, Turner C, Beer NL, Swift AJ, Morken MA, Below JE, Blech I, NISC Comparative Sequencing Program, Mullikin JC, McCarthy MI, Biesecker LG, Gloyn AL, Collins FS.
    J Clin Invest; 2012 Jan 29; 122(1):205-17. PubMed ID: 22182842
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  • 12. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.
    Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N.
    Proc Natl Acad Sci U S A; 1999 Dec 07; 96(25):14511-6. PubMed ID: 10588736
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  • 13. Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.
    Martinez JA, Xiao Q, Zakarian A, Miller BG.
    Biochemistry; 2017 Jun 20; 56(24):3150-3157. PubMed ID: 28516783
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  • 14. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
    Lloyd DJ, St Jean DJ, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, Chen K, Chmait S, Zhang J, Liu L, Norman MH, Andrews KL, Bartberger MD, Van G, Galbreath EJ, Vonderfecht SL, Wang M, Jordan SR, Véniant MM, Hale C.
    Nature; 2013 Dec 19; 504(7480):437-40. PubMed ID: 24226772
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  • 15. Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.
    Park JM, Kim TH, Jo SH, Kim MY, Ahn YH.
    Sci Rep; 2015 Dec 01; 5():17395. PubMed ID: 26620281
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  • 16. Characterization of glucokinase regulatory protein-deficient mice.
    Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF.
    J Biol Chem; 2000 Mar 17; 275(11):7826-31. PubMed ID: 10713097
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  • 18. Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.
    Kaushik A, Kaushik M.
    Curr Diabetes Rev; 2019 Mar 17; 15(3):205-212. PubMed ID: 30039763
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  • 19. Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants.
    Ford BE, Chachra SS, Alshawi A, Oakley F, Fairclough RJ, Smith DM, Tiniakos D, Agius L.
    Biochem Pharmacol; 2024 Nov 17; 229():116499. PubMed ID: 39173844
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  • 20. ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.
    Singh C, Jin B, Shrestha N, Markhard AL, Panda A, Calvo SE, Deik A, Pan X, Zuckerman AL, Ben Saad A, Corey KE, Sjoquist J, Osganian S, AminiTabrizi R, Rhee EP, Shah H, Goldberger O, Mullen AC, Cracan V, Clish CB, Mootha VK, Goodman RP.
    Cell Metab; 2024 Jan 02; 36(1):144-158.e7. PubMed ID: 38101397
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