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Journal Abstract Search

246 related items for PubMed ID: 25695315

  • 1. Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.
    Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Lee KH, Goto M.
    J Med Chem; 2015 Mar 12; 58(5):2378-89. PubMed ID: 25695315
    [Abstract] [Full Text] [Related]

  • 2. CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells.
    Dinić J, Ríos-Luci C, Karpaviciene I, Cikotiene I, Fernandes MX, Pešić M, Padrón JM.
    Invest New Drugs; 2020 Jun 12; 38(3):584-598. PubMed ID: 31177401
    [Abstract] [Full Text] [Related]

  • 3. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
    Cheng B, Zhu G, Meng L, Wu G, Chen Q, Ma S.
    Eur J Med Chem; 2022 Jan 15; 228():113930. PubMed ID: 34794817
    [Abstract] [Full Text] [Related]

  • 4. Antitubulin effects of aminobenzothiophene-substituted triethylated chromones.
    Kobayashi Y, Saito Y, Goto M, Nakagawa-Goto K.
    Bioorg Med Chem Lett; 2017 Jun 15; 27(12):2731-2735. PubMed ID: 28457756
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of quinoline analogues of flavones as potential anticancer agents and tubulin polymerization inhibitors.
    Shobeiri N, Rashedi M, Mosaffa F, Zarghi A, Ghandadi M, Ghasemi A, Ghodsi R.
    Eur J Med Chem; 2016 May 23; 114():14-23. PubMed ID: 26974371
    [Abstract] [Full Text] [Related]

  • 6. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
    Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G.
    Eur J Med Chem; 2018 Jan 01; 143():683-698. PubMed ID: 29220790
    [Abstract] [Full Text] [Related]

  • 7. Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.
    Nakagawa-Goto K, Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH.
    J Med Chem; 2011 Mar 10; 54(5):1244-55. PubMed ID: 21284385
    [Abstract] [Full Text] [Related]

  • 8. Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative.
    Sawada JI, Ishii H, Matsuno K, Sato M, Suzuki Y, Asai A.
    Mol Pharmacol; 2019 Nov 10; 96(5):609-618. PubMed ID: 31471455
    [Abstract] [Full Text] [Related]

  • 9. Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
    Maklad RM, AbdelHafez EMN, Abdelhamid D, Aly OM.
    Bioorg Chem; 2020 Jun 10; 99():103767. PubMed ID: 32325332
    [Abstract] [Full Text] [Related]

  • 10. (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
    Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP.
    J Med Chem; 2012 Jun 14; 55(11):5174-87. PubMed ID: 22587519
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
    Cosentino L, Redondo-Horcajo M, Zhao Y, Santos AR, Chowdury KF, Vinader V, Abdallah QM, Abdel-Rahman H, Fournier-Dit-Chabert J, Shnyder SD, Loadman PM, Fang WS, Díaz JF, Barasoain I, Burns PA, Pors K.
    J Med Chem; 2012 Dec 27; 55(24):11062-6. PubMed ID: 23176628
    [Abstract] [Full Text] [Related]

  • 12. Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine.
    Rathinasamy K, Jindal B, Asthana J, Singh P, Balaji PV, Panda D.
    BMC Cancer; 2010 May 19; 10():213. PubMed ID: 20482847
    [Abstract] [Full Text] [Related]

  • 13. Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.
    Canela MD, Pérez-Pérez MJ, Noppen S, Sáez-Calvo G, Díaz JF, Camarasa MJ, Liekens S, Priego EM.
    J Med Chem; 2014 May 22; 57(10):3924-38. PubMed ID: 24773591
    [Abstract] [Full Text] [Related]

  • 14. PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.
    Martínez-Díez M, Guillén-Navarro MJ, Pera B, Bouchet BP, Martínez-Leal JF, Barasoain I, Cuevas C, Andreu JM, García-Fernández LF, Díaz JF, Avilés P, Galmarini CM.
    Biochem Pharmacol; 2014 Apr 01; 88(3):291-302. PubMed ID: 24486569
    [Abstract] [Full Text] [Related]

  • 15. Triethylated chromones with substituted naphthalenes as tubulin inhibitors.
    Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M.
    Bioorg Med Chem; 2016 Nov 15; 24(22):6048-6057. PubMed ID: 27707623
    [Abstract] [Full Text] [Related]

  • 16. Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.
    Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.
    J Med Chem; 2014 Aug 14; 57(15):6364-82. PubMed ID: 25061803
    [Abstract] [Full Text] [Related]

  • 17. Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine.
    Mohan L, Raghav D, Ashraf SM, Sebastian J, Rathinasamy K.
    Biomed Pharmacother; 2018 Sep 14; 105():506-517. PubMed ID: 29883946
    [Abstract] [Full Text] [Related]

  • 18. Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents.
    Tangutur AD, Kumar D, Krishna KV, Kantevari S.
    Curr Top Med Chem; 2017 Sep 14; 17(22):2523-2537. PubMed ID: 28056738
    [Abstract] [Full Text] [Related]

  • 19. Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor.
    Hsu LC, Durrant DE, Huang CC, Chi NW, Baruchello R, Rondanin R, Rullo C, Marchetti P, Grisolia G, Simoni D, Lee RM.
    Invest New Drugs; 2012 Aug 14; 30(4):1379-88. PubMed ID: 21655917
    [Abstract] [Full Text] [Related]

  • 20. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance.
    Aoyama A, Katayama R, Oh-Hara T, Sato S, Okuno Y, Fujita N.
    Mol Cancer Ther; 2014 Dec 14; 13(12):2978-90. PubMed ID: 25313010
    [Abstract] [Full Text] [Related]

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