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Journal Abstract Search


387 related items for PubMed ID: 25735838

  • 1.
    ; . PubMed ID:
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  • 2. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
    Coleman T, Ellis SW, Martin IJ, Lennard MS, Tucker GT.
    J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
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  • 3. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T, Guillén H, Arán VJ, Idle JR, Gonzalez FJ.
    Toxicol Appl Pharmacol; 2006 Nov 01; 216(3):387-98. PubMed ID: 16870220
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  • 4. Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers.
    Uehara S, Ishii S, Uno Y, Inoue T, Sasaki E, Yamazaki H.
    Drug Metab Dispos; 2017 Aug 01; 45(8):896-899. PubMed ID: 28495902
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  • 5. Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.
    Uehara S, Shimizu M, Uno Y, Inoue T, Sasaki E, Yamazaki H.
    Drug Metab Dispos; 2017 May 01; 45(5):497-500. PubMed ID: 28258069
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  • 6. Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.
    Taniguchi-Takizawa T, Shimizu M, Kume T, Yamazaki H.
    Drug Metab Pharmacokinet; 2015 Feb 01; 30(1):64-9. PubMed ID: 25760531
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  • 7. Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations.
    Cashman JR, Ziegler DM.
    Mol Pharmacol; 1986 Feb 01; 29(2):163-7. PubMed ID: 3485239
    [Abstract] [Full Text] [Related]

  • 8. Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.
    Uehara S, Uno Y, Hagihira Y, Murayama N, Shimizu M, Inoue T, Sasaki E, Yamazaki H.
    Xenobiotica; 2015 Feb 01; 45(9):766-72. PubMed ID: 25801057
    [Abstract] [Full Text] [Related]

  • 9. Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
    Chiba K, Kubota E, Miyakawa T, Kato Y, Ishizaki T.
    J Pharmacol Exp Ther; 1988 Sep 01; 246(3):1108-15. PubMed ID: 3262153
    [Abstract] [Full Text] [Related]

  • 10. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H, Guo Z, Persmark M, Mimura M, Inoue K, Guengerich FP, Shimada T.
    Mol Pharmacol; 1994 Sep 01; 46(3):568-77. PubMed ID: 7935340
    [Abstract] [Full Text] [Related]

  • 11. A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine.
    Uehara S, Uno Y, Yuki Y, Inoue T, Sasaki E, Yamazaki H.
    Drug Metab Dispos; 2016 Jun 01; 44(6):833-41. PubMed ID: 27044800
    [Abstract] [Full Text] [Related]

  • 12. Quantitative analysis of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism in isolated rat hepatocytes.
    Di Monte D, Shinka T, Sandy MS, Castagnoli N, Smith MT.
    Drug Metab Dispos; 1988 Jun 01; 16(2):250-5. PubMed ID: 2898342
    [Abstract] [Full Text] [Related]

  • 13. Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes.
    Nakanishi K, Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.
    Xenobiotica; 2018 Aug 01; 48(8):757-763. PubMed ID: 28762864
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  • 18. Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase.
    Kousba A, Soll R, Yee S, Martin M.
    Drug Metab Dispos; 2007 Dec 01; 35(12):2242-51. PubMed ID: 17881660
    [Abstract] [Full Text] [Related]

  • 19. Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation.
    Li XX, Wang Y, Zheng QC, Zhang HX.
    J Inorg Biochem; 2016 Jan 01; 154():21-8. PubMed ID: 26544505
    [Abstract] [Full Text] [Related]

  • 20. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
    Modi S, Gilham DE, Sutcliffe MJ, Lian LY, Primrose WU, Wolf CR, Roberts GC.
    Biochemistry; 1997 Apr 15; 36(15):4461-70. PubMed ID: 9109653
    [Abstract] [Full Text] [Related]


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