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Journal Abstract Search

183 related items for PubMed ID: 25793650

  • 1. Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
    Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P.
    J Med Chem; 2015 Apr 09; 58(7):3172-87. PubMed ID: 25793650
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.
    Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P.
    Eur J Med Chem; 2016 Oct 04; 121():283-293. PubMed ID: 27266998
    [Abstract] [Full Text] [Related]

  • 3. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.
    Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P.
    Proc Natl Acad Sci U S A; 2014 Sep 09; 111(36):E3825-30. PubMed ID: 25157130
    [Abstract] [Full Text] [Related]

  • 4. Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
    Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C.
    Eur J Med Chem; 2019 Jan 15; 162():234-248. PubMed ID: 30447434
    [Abstract] [Full Text] [Related]

  • 5. Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease.
    Lalut J, Payan H, Davis A, Lecoutey C, Legay R, Sopkova-de Oliveira Santos J, Claeysen S, Dallemagne P, Rochais C.
    Sci Rep; 2020 Feb 20; 10(1):3014. PubMed ID: 32080261
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.
    Castriconi F, Paolino M, Giuliani G, Anzini M, Campiani G, Mennuni L, Sabatini C, Lanza M, Caselli G, De Rienzo F, Menziani MC, Sbraccia M, Molinari P, Costa T, Cappelli A.
    Eur J Med Chem; 2014 Jul 23; 82():36-46. PubMed ID: 24871995
    [Abstract] [Full Text] [Related]

  • 7. Dual histamine H3R/serotonin 5-HT4R ligands with antiamnesic properties: pharmacophore-based virtual screening and polypharmacology.
    Lepailleur A, Freret T, Lemaître S, Boulouard M, Dauphin F, Hinschberger A, Dulin F, Lesnard A, Bureau R, Rault S.
    J Chem Inf Model; 2014 Jun 23; 54(6):1773-84. PubMed ID: 24857631
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
    Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimarães MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C.
    Eur J Med Chem; 2017 Apr 21; 130():440-457. PubMed ID: 28282613
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.
    Li Y, Peng P, Tang L, Hu Y, Hu Y, Sheng R.
    Bioorg Med Chem; 2014 Sep 01; 22(17):4717-25. PubMed ID: 25082512
    [Abstract] [Full Text] [Related]

  • 10. Discovery of multitarget-directed ligands against Alzheimer's disease through systematic prediction of chemical-protein interactions.
    Fang J, Li Y, Liu R, Pang X, Li C, Yang R, He Y, Lian W, Liu AL, Du GH.
    J Chem Inf Model; 2015 Jan 26; 55(1):149-64. PubMed ID: 25531792
    [Abstract] [Full Text] [Related]

  • 11. Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease.
    Lanthier C, Payan H, Liparulo I, Hatat B, Lecoutey C, Since M, Davis A, Bergamini C, Claeysen S, Dallemagne P, Bolognesi ML, Rochais C.
    Eur J Med Chem; 2019 Nov 15; 182():111596. PubMed ID: 31419776
    [Abstract] [Full Text] [Related]

  • 12. Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.
    Quiedeville A, Boulouard M, Hamidouche K, Da Silva Costa-Aze V, Nee G, Rochais C, Dallemagne P, Fabis F, Freret T, Bouet V.
    Behav Brain Res; 2015 Oct 15; 293():10-7. PubMed ID: 26187692
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists.
    Nirogi R, Mohammed AR, Shinde AK, Gagginapally SR, Kancharla DM, Middekadi VR, Bogaraju N, Ravella SR, Singh P, Birangal SR, Subramanian R, Palacharla RC, Benade V, Muddana N, Jayarajan P.
    J Med Chem; 2018 Jun 14; 61(11):4993-5008. PubMed ID: 29763304
    [Abstract] [Full Text] [Related]

  • 14. Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.
    McKinnell RM, Armstrong SR, Beattie DT, Fatheree PR, Long DD, Marquess DG, Shaw JP, Vickery RG.
    Bioorg Med Chem Lett; 2013 Jul 15; 23(14):4210-5. PubMed ID: 23756062
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
    Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.
    Bioorg Med Chem; 2007 Oct 15; 15(20):6596-607. PubMed ID: 17681794
    [Abstract] [Full Text] [Related]

  • 16. Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy.
    Lecoutey C, Legay R, Davis A, Sopková-de Oliveira Santos J, Dallemagne P, Rochais C.
    Molecules; 2021 Apr 26; 26(9):. PubMed ID: 33926141
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
    Luo Z, Sheng J, Sun Y, Lu C, Yan J, Liu A, Luo HB, Huang L, Li X.
    J Med Chem; 2013 Nov 27; 56(22):9089-99. PubMed ID: 24160297
    [Abstract] [Full Text] [Related]

  • 18. Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse.
    Freret T, Lelong-Boulouard V, Lecouflet P, Hamidouche K, Dauphin F, Boulouard M.
    Psychopharmacology (Berl); 2017 Aug 27; 234(15):2365-2374. PubMed ID: 28631100
    [Abstract] [Full Text] [Related]

  • 19. Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.
    Girisha HR, Narendra Sharath Chandra JN, Boppana S, Malviya M, Sadashiva CT, Rangappa KS.
    Eur J Med Chem; 2009 Oct 27; 44(10):4057-62. PubMed ID: 19493592
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Shao D, Zou C, Luo C, Tang X, Li Y.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4639-42. PubMed ID: 15324879
    [Abstract] [Full Text] [Related]

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