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Journal Abstract Search

502 related items for PubMed ID: 25799376

  • 1. Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
    Chen TC, Wu CL, Lee CC, Chen CL, Yu DS, Huang HS.
    Eur J Med Chem; 2015 Oct 20; 103():615-27. PubMed ID: 25799376
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT, Woo H, Jeong HM, Khadka DB, Yang SH, Zhao C, Jin Y, Lee ES, Youl Lee K, Kwon Y, Cho WJ.
    Eur J Med Chem; 2014 Jul 23; 82():181-94. PubMed ID: 24904965
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.
    Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.
    Org Biomol Chem; 2013 Jun 28; 11(24):3989-4005. PubMed ID: 23657605
    [Abstract] [Full Text] [Related]

  • 4. Pyrroloquinolinone-based dual topoisomerase I/II inhibitor.
    Dalla Via L, Marzaro G, Ferrarese A, Gia O, Chilin A.
    Eur J Med Chem; 2014 Apr 22; 77():103-9. PubMed ID: 24631729
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.
    Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO.
    Org Biomol Chem; 2013 Feb 28; 11(8):1334-44. PubMed ID: 23314103
    [Abstract] [Full Text] [Related]

  • 6. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
    Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES.
    Eur J Med Chem; 2016 May 04; 113():228-45. PubMed ID: 26945111
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
    Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES.
    Bioorg Chem; 2016 Jun 04; 66():145-59. PubMed ID: 27174797
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
    Genès C, Lenglet G, Depauw S, Nhili R, Prado S, David-Cordonnier MH, Michel S, Tillequin F, Porée FH.
    Eur J Med Chem; 2011 Jun 04; 46(6):2117-31. PubMed ID: 21435753
    [Abstract] [Full Text] [Related]

  • 9. Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    Abdel-Aziz M, Park SE, Abuo-Rahma Gel-D, Sayed MA, Kwon Y.
    Eur J Med Chem; 2013 Nov 04; 69():427-38. PubMed ID: 24090914
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues.
    Song YL, Dong YF, Yang T, Zhang CC, Su LM, Huang X, Zhang DN, Yang GL, Liu YX.
    Bioorg Med Chem; 2013 Dec 15; 21(24):7624-7. PubMed ID: 24262885
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.
    Yao BL, Mai YW, Chen SB, Xie HT, Yao PF, Ou TM, Tan JH, Wang HG, Li D, Huang SL, Gu LQ, Huang ZS.
    Eur J Med Chem; 2015 Mar 06; 92():540-53. PubMed ID: 25599951
    [Abstract] [Full Text] [Related]

  • 12. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.
    Park S, Thapa Magar TB, Kadayat TM, Lee HJ, Bist G, Shrestha A, Lee ES, Kwon Y.
    Eur J Med Chem; 2017 Feb 15; 127():318-333. PubMed ID: 28068603
    [Abstract] [Full Text] [Related]

  • 13. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Thapa U, Thapa P, Karki R, Yun M, Choi JH, Jahng Y, Lee E, Jeon KH, Na Y, Ha EM, Cho WJ, Kwon Y, Lee ES.
    Eur J Med Chem; 2011 Aug 15; 46(8):3201-9. PubMed ID: 21601964
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.
    Zhang X, Wang R, Zhao L, Lu N, Wang J, You Q, Li Z, Guo Q.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1276-81. PubMed ID: 22079759
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives.
    Zhou Y, Xu X, Sun Y, Wang H, Sun H, You Q.
    Bioorg Med Chem Lett; 2013 May 15; 23(10):2974-8. PubMed ID: 23566520
    [Abstract] [Full Text] [Related]

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  • 17. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.
    Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES.
    Bioorg Med Chem; 2015 Jul 01; 23(13):3499-512. PubMed ID: 26022080
    [Abstract] [Full Text] [Related]

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  • 19. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W, Chen L, Li HM, Wang DJ, Li DS, Chen T, Yuan ZP, Tang YJ.
    Bioorg Med Chem; 2014 Jun 01; 22(11):2998-3007. PubMed ID: 24775914
    [Abstract] [Full Text] [Related]

  • 20. Synthesis, computational quantum chemical study, in silico ADMET and molecular docking analysis, in vitro biological evaluation of a novel sulfur heterocyclic thiophene derivative containing 1,2,3-triazole and pyridine moieties as a potential human topoisomerase IIα inhibiting anticancer agent.
    Murugavel S, Ravikumar C, Jaabil G, Alagusundaram P.
    Comput Biol Chem; 2019 Apr 01; 79():73-82. PubMed ID: 30731361
    [Abstract] [Full Text] [Related]

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