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180 related items for PubMed ID: 25809254

  • 1. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
    Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY.
    Biophys J; 2015 Mar 24; 108(6):1414-1424. PubMed ID: 25809254
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  • 2. NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
    Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ.
    Biophys J; 2015 Mar 24; 108(6):1400-1413. PubMed ID: 25809253
    [Abstract] [Full Text] [Related]

  • 3. Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
    Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.
    J Pharmacol Exp Ther; 2012 Aug 24; 342(2):441-52. PubMed ID: 22573844
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  • 5. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
    Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M.
    Mol Pharmacol; 2006 Jan 24; 69(1):266-77. PubMed ID: 16219910
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  • 6. NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2.
    Huo J, Guo X, Lu Q, Qiang H, Liu P, Bai L, Huang CL, Zhang Y, Ma A.
    Clin Exp Pharmacol Physiol; 2017 Nov 24; 44(11):1125-1133. PubMed ID: 28741726
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  • 11. Activation of ERG2 potassium channels by the diphenylurea NS1643.
    Elmedyb P, Olesen SP, Grunnet M.
    Neuropharmacology; 2007 Aug 24; 53(2):283-94. PubMed ID: 17610913
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  • 12. Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells.
    Schuster AM, Glassmeier G, Bauer CK.
    Mol Pharmacol; 2011 Nov 24; 80(5):930-42. PubMed ID: 21856740
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  • 13. Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.
    Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ.
    PLoS One; 2014 Nov 24; 9(9):e105553. PubMed ID: 25191697
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  • 14. Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization.
    Meng J, Shi C, Li L, Du Y, Xu Y.
    Eur J Pharmacol; 2013 Oct 15; 718(1-3):87-97. PubMed ID: 24041920
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  • 15. Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression.
    Huo J, Zhang A, Guo X, Qiang H, Liu P, Bai L, Ma A.
    Clin Exp Pharmacol Physiol; 2016 Sep 15; 43(9):851-61. PubMed ID: 27199074
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  • 16. Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.
    Balijepalli SY, Lim E, Concannon SP, Chew CL, Holzem KE, Tester DJ, Ackerman MJ, Delisle BP, Balijepalli RC, January CT.
    Circulation; 2012 Dec 11; 126(24):2809-18. PubMed ID: 23136156
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  • 17. Enhanced repolarization capacity: new potential antiarrhythmic strategy based on HERG channel activation.
    Szabó G, Farkas V, Grunnet M, Mohácsi A, Nánási PP.
    Curr Med Chem; 2011 Dec 11; 18(24):3607-21. PubMed ID: 21774764
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  • 18. Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
    Peitersen T, Grunnet M, Benson AP, Holden AV, Holstein-Rathlou NH, Olesen SP.
    Heart Rhythm; 2008 May 11; 5(5):734-41. PubMed ID: 18452879
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  • 19. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.
    Bentzen BH, Bahrke S, Wu K, Larsen AP, Odening KE, Franke G, Storm vańs Gravesande K, Biermann J, Peng X, Koren G, Zehender M, Bode C, Grunnet M, Brunner M.
    J Cardiovasc Pharmacol; 2011 Feb 11; 57(2):223-30. PubMed ID: 21135701
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  • 20. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
    Li P, Chen X, Zhang Q, Zheng Y, Jiang H, Yang H, Gao Z.
    J Pharmacol Exp Ther; 2014 Dec 11; 351(3):596-604. PubMed ID: 25232191
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