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Journal Abstract Search

350 related items for PubMed ID: 25838146

  • 1. Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors.
    Mo DW, Dong S, Sun H, Chen JS, Pang JX, Xi BM, Chen WH.
    Bioorg Med Chem Lett; 2015 May 01; 25(9):1872-5. PubMed ID: 25838146
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.
    Liu Y, Si M, Tang L, Shangguan S, Wu H, Li J, Wu P, Ma X, Liu T, Hu Y.
    Bioorg Med Chem; 2013 Sep 15; 21(18):5679-87. PubMed ID: 23938053
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  • 4. [Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors].
    Han B, Huan Y, Lin ZY, Li P, Shen ZF, Yin DL, Huang HH.
    Yao Xue Xue Bao; 2010 Nov 15; 45(11):1379-84. PubMed ID: 21361038
    [Abstract] [Full Text] [Related]

  • 5. Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.
    Zeng S, Xie H, Zeng LL, Lu X, Zhao X, Zhang GC, Tu ZC, Xu HJ, Yang L, Zhang XQ, Hu W.
    Bioorg Med Chem; 2013 Apr 01; 21(7):1749-55. PubMed ID: 23434133
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors.
    Sharma M, Singh D, Gupta M.
    Chem Biol Drug Des; 2013 Feb 01; 81(2):257-64. PubMed ID: 23039850
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  • 8. Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.
    Jiang T, Zhou Y, Zhu J, Chen Z, Sun P, Zhang Q, Wang Z, Shao Q, Jiang X, Li B, Wang H, Zhu W, Shen J.
    Arch Pharm (Weinheim); 2015 Jun 01; 348(6):399-407. PubMed ID: 25871012
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  • 9. Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.
    Wang L, Zhang B, Ji J, Li B, Yan J, Zhang W, Wu Y, Wang X.
    Eur J Med Chem; 2009 Aug 01; 44(8):3318-22. PubMed ID: 19375196
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  • 10. Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin.
    Lai ZW, Li C, Liu J, Kong L, Wen X, Sun H.
    Eur J Med Chem; 2014 Aug 18; 83():547-60. PubMed ID: 24996141
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, Biological Evaluation, and Molecular Docking of (R)-2-((8-(3-aminopiperidin-1-yl)-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)benzonitrile as Dipeptidyl Peptidase IV Inhibitors.
    Ran Y, Pei H, Shao M, Chen L.
    Chem Biol Drug Des; 2016 Feb 18; 87(2):290-5. PubMed ID: 26426933
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  • 13. Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors.
    Zhang L, Su M, Li J, Ji X, Wang J, Li Z, Li J, Liu H.
    Chem Biol Drug Des; 2013 Feb 18; 81(2):198-207. PubMed ID: 22994702
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  • 15. Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors.
    Li N, Wang LJ, Jiang B, Guo SJ, Li XQ, Chen XC, Luo J, Li C, Wang Y, Shi DY.
    Bioorg Med Chem Lett; 2018 Jul 01; 28(12):2131-2135. PubMed ID: 29773502
    [Abstract] [Full Text] [Related]

  • 16. Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions.
    Watanabe YS, Yasuda Y, Kojima Y, Okada S, Motoyama T, Takahashi R, Oka M.
    J Enzyme Inhib Med Chem; 2015 Dec 01; 30(6):981-8. PubMed ID: 26147347
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  • 18. Design, synthesis, biological evaluation, and docking studies of (s)-phenylalanine derivatives with a 2-cyanopyrrolidine moiety as potent dipeptidyl peptidase 4 inhibitors.
    Liu Y, Wu Y, Wu H, Tang L, Wu P, Liu T, Hu Y.
    Chem Biol Drug Des; 2013 Aug 01; 82(2):140-6. PubMed ID: 23530834
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.
    Bindu B, Vijayalakshmi S, Manikandan A.
    Eur J Med Chem; 2020 Feb 01; 187():111912. PubMed ID: 31812034
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