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190 related items for PubMed ID: 25843719

  • 1. A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.
    Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS.
    Cell Rep; 2015 Apr 14; 11(2):295-307. PubMed ID: 25843719
    [Abstract] [Full Text] [Related]

  • 2. Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.
    Carvalho-Filho MA, Carvalho BM, Oliveira AG, Guadagnini D, Ueno M, Dias MM, Tsukumo DM, Hirabara SM, Reis LF, Curi R, Carvalheira JB, Saad MJ.
    Endocrinology; 2012 Nov 14; 153(11):5261-74. PubMed ID: 22948222
    [Abstract] [Full Text] [Related]

  • 3. Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival.
    Chukwurah E, Patel RC.
    Sci Rep; 2018 Jan 18; 8(1):1020. PubMed ID: 29348664
    [Abstract] [Full Text] [Related]

  • 4. Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation.
    Singh M, Castillo D, Patel CV, Patel RC.
    Biochemistry; 2011 May 31; 50(21):4550-60. PubMed ID: 21526770
    [Abstract] [Full Text] [Related]

  • 5. TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.
    Daher A, Laraki G, Singh M, Melendez-Peña CE, Bannwarth S, Peters AH, Meurs EF, Braun RE, Patel RC, Gatignol A.
    Mol Cell Biol; 2009 Jan 31; 29(1):254-65. PubMed ID: 18936160
    [Abstract] [Full Text] [Related]

  • 6. Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.
    Chukwurah E, Willingham V, Singh M, Castillo-Azofeifa D, Patel RC.
    J Cell Biochem; 2018 Apr 31; 119(4):3598-3607. PubMed ID: 29231267
    [Abstract] [Full Text] [Related]

  • 7. The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR.
    Dorin D, Bonnet MC, Bannwarth S, Gatignol A, Meurs EF, Vaquero C.
    J Biol Chem; 2003 Feb 14; 278(7):4440-8. PubMed ID: 12475984
    [Abstract] [Full Text] [Related]

  • 8. The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR.
    Sanghvi VR, Steel LF.
    J Virol; 2011 Dec 14; 85(23):12614-21. PubMed ID: 21937648
    [Abstract] [Full Text] [Related]

  • 9. Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation.
    Ukhueduan B, Chukwurah E, Patel RC.
    Int J Biochem Cell Biol; 2021 Aug 14; 137():106030. PubMed ID: 34174402
    [Abstract] [Full Text] [Related]

  • 10. Deletion of human tarbp2 reveals cellular microRNA targets and cell-cycle function of TRBP.
    Kim Y, Yeo J, Lee JH, Cho J, Seo D, Kim JS, Kim VN.
    Cell Rep; 2014 Nov 06; 9(3):1061-74. PubMed ID: 25437560
    [Abstract] [Full Text] [Related]

  • 11. The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation.
    Kimball SR, Clemens MJ, Tilleray VJ, Wek RC, Horetsky RL, Jefferson LS.
    Biochem Biophys Res Commun; 2001 Jan 12; 280(1):293-300. PubMed ID: 11162513
    [Abstract] [Full Text] [Related]

  • 12. Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response.
    Burnett SB, Vaughn LS, Sharma N, Kulkarni R, Patel RC.
    Neurobiol Dis; 2020 Dec 12; 146():105135. PubMed ID: 33049316
    [Abstract] [Full Text] [Related]

  • 13. Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans.
    Carvalho BM, Oliveira AG, Ueno M, Araújo TG, Guadagnini D, Carvalho-Filho MA, Geloneze B, Lima MM, Pareja JC, Carvalheira JB, Saad MJ.
    Obesity (Silver Spring); 2013 Dec 12; 21(12):2452-7. PubMed ID: 23519983
    [Abstract] [Full Text] [Related]

  • 14. Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.
    Benkirane M, Neuveut C, Chun RF, Smith SM, Samuel CE, Gatignol A, Jeang KT.
    EMBO J; 1997 Feb 03; 16(3):611-24. PubMed ID: 9034343
    [Abstract] [Full Text] [Related]

  • 15. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.
    Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A.
    Retrovirology; 2013 Sep 11; 10():96. PubMed ID: 24020926
    [Abstract] [Full Text] [Related]

  • 16. Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
    Ventoso I, Sanz MA, Molina S, Berlanga JJ, Carrasco L, Esteban M.
    Genes Dev; 2006 Jan 01; 20(1):87-100. PubMed ID: 16391235
    [Abstract] [Full Text] [Related]

  • 17. The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.
    Dickerman BK, White CL, Kessler PM, Sadler AJ, Williams BR, Sen GC.
    FEBS J; 2015 Dec 01; 282(24):4766-81. PubMed ID: 26414443
    [Abstract] [Full Text] [Related]

  • 18. Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome.
    Sud N, Rutledge AC, Pan K, Su Q.
    Curr Pharm Des; 2016 Dec 01; 22(18):2697-703. PubMed ID: 26831644
    [Abstract] [Full Text] [Related]

  • 19. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression.
    Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A.
    J Biol Chem; 2001 Sep 07; 276(36):33899-905. PubMed ID: 11438532
    [Abstract] [Full Text] [Related]

  • 20. Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma.
    Chen HY, Lin LT, Wang ML, Tsai KL, Huang PI, Yang YP, Lee YY, Chen YW, Lo WL, Lan YT, Chiou SH, Lin CM, Ma HI, Chen MT.
    Biochim Biophys Acta Mol Basis Dis; 2018 May 07; 1864(5 Pt A):1850-1861. PubMed ID: 29486283
    [Abstract] [Full Text] [Related]

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