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193 related items for PubMed ID: 25849139

  • 1. Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.
    Maiti M, Maiti M, Rozenski J, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2015 May 14; 13(18):5158-74. PubMed ID: 25849139
    [Abstract] [Full Text] [Related]

  • 2. Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
    Maiti M, Gao LJ, Huang C, Ptak RG, Murray MG, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2016 Sep 21; 14(37):8743-8757. PubMed ID: 27714209
    [Abstract] [Full Text] [Related]

  • 3. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
    Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.
    Antivir Chem Chemother; 2009 Oct 19; 20(2):99-106. PubMed ID: 19843980
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
    Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2015 Mar 01; 25(5):1040-3. PubMed ID: 25650256
    [Abstract] [Full Text] [Related]

  • 5. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
    McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.
    J Med Chem; 2010 Jul 08; 53(13):4949-57. PubMed ID: 20527890
    [Abstract] [Full Text] [Related]

  • 6. The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
    McGuigan C, Perrone P, Madela K, Neyts J.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4316-20. PubMed ID: 19523820
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and anti-herpetic activity of phosphoramidate ProTides.
    Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.
    ChemMedChem; 2013 Jun 01; 8(6):985-93. PubMed ID: 23606629
    [Abstract] [Full Text] [Related]

  • 8. Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
    Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.
    J Med Chem; 2009 Sep 10; 52(17):5394-407. PubMed ID: 19725579
    [Abstract] [Full Text] [Related]

  • 9. Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
    McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.
    Bioorg Med Chem Lett; 2011 Oct 01; 21(19):6007-12. PubMed ID: 21856153
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
    Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, Gorovits E, Kolykhalov A, Muhammad J, Patti J, Henson G, Bleiman B, Bryant KD, Ganguly B, Hunley D, Obikhod A, Walters CR, Wang J, Ramamurty CV, Battina SK, Srivinas Rao C.
    Bioorg Med Chem Lett; 2013 Apr 01; 23(7):2260-4. PubMed ID: 23453067
    [Abstract] [Full Text] [Related]

  • 11. Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
    Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU.
    Bioorg Med Chem Lett; 2017 Apr 15; 27(8):1840-1847. PubMed ID: 28274633
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
    Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.
    Bioorg Med Chem Lett; 2017 Dec 01; 27(23):5296-5299. PubMed ID: 29066308
    [Abstract] [Full Text] [Related]

  • 13. The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
    McGuigan C, Daverio F, Nájera I, Martin JA, Klumpp K, Smith DB.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3122-4. PubMed ID: 19398331
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
    Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.
    Bioorg Med Chem; 2014 Dec 01; 22(23):6665-6671. PubMed ID: 25458500
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of diastereomerically pure nucleotide phosphoramidates.
    Ross BS, Reddy PG, Zhang HR, Rachakonda S, Sofia MJ.
    J Org Chem; 2011 Oct 21; 76(20):8311-9. PubMed ID: 21916475
    [Abstract] [Full Text] [Related]

  • 16. QSAR models for phosphoramidate prodrugs of 2'-methylcytidine as inhibitors of hepatitis C virus based on PSO boosting.
    Cheng Z, Zhang Y, Zhou C.
    Chem Biol Drug Des; 2011 Dec 21; 78(6):948-59. PubMed ID: 21895985
    [Abstract] [Full Text] [Related]

  • 17. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction.
    Pertusati F, McGuigan C.
    Chem Commun (Camb); 2015 May 11; 51(38):8070-3. PubMed ID: 25867944
    [Abstract] [Full Text] [Related]

  • 18. A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.
    Sun Q, Li X, Gong S, Liu G, Shen L, Peng L.
    Nucleosides Nucleotides Nucleic Acids; 2013 May 11; 32(11):617-38. PubMed ID: 24138500
    [Abstract] [Full Text] [Related]

  • 19. Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
    Gudmundsson KS, Daluge SM, Johnson LC, Jansen R, Hazen R, Condreay LD, McGuigan C.
    Nucleosides Nucleotides Nucleic Acids; 2003 Oct 11; 22(10):1953-61. PubMed ID: 14609234
    [Abstract] [Full Text] [Related]

  • 20. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity.
    Slusarczyk M, Serpi M, Pertusati F.
    Antivir Chem Chemother; 2018 Oct 11; 26():2040206618775243. PubMed ID: 29792071
    [Abstract] [Full Text] [Related]

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