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203 related items for PubMed ID: 25905574

  • 1. Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine.
    Seid CA, Curti E, Jones RM, Hudspeth E, Rezende W, Pollet J, Center L, Versteeg L, Pritchard S, Musiychuk K, Yusibov V, Hotez PJ, Bottazzi ME.
    Hum Vaccin Immunother; 2015; 11(6):1474-88. PubMed ID: 25905574
    [Abstract] [Full Text] [Related]

  • 2. Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate.
    Curti E, Seid CA, Hudspeth E, Center L, Rezende W, Pollet J, Kwityn C, Hammond M, Matsunami RK, Engler DA, Hotez PJ, Elena Bottazzi M.
    Hum Vaccin Immunother; 2014; 10(7):1914-25. PubMed ID: 25424799
    [Abstract] [Full Text] [Related]

  • 3. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.
    Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A.
    Hum Vaccin Immunother; 2015; 11(5):1251-7. PubMed ID: 26018444
    [Abstract] [Full Text] [Related]

  • 4. Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial.
    Zinsou JF, Diemert DJ, Dejon-Agobé JC, Adégbité BR, Honkpehedji YJ, Vodonou KG, Bikangui R, Edoa JR, Massinga Loembe M, Li G, Yazdanbakhsh M, Bottazzi ME, van Leeuwen R, Kremsner PG, Hotez PJ, Bethony JM, Grobusch MP, Adegnika AA.
    Lancet Infect Dis; 2024 Jul; 24(7):760-774. PubMed ID: 38513684
    [Abstract] [Full Text] [Related]

  • 5. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen.
    Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME.
    Protein Expr Purif; 2012 Jun; 83(2):145-51. PubMed ID: 22503665
    [Abstract] [Full Text] [Related]

  • 6. Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults.
    Diemert DJ, Zumer M, Campbell D, Grahek S, Li G, Peng J, Elena Bottazzi M, Hotez P, Bethony J.
    Vaccine; 2022 Oct 06; 40(42):6084-6092. PubMed ID: 36114129
    [Abstract] [Full Text] [Related]

  • 7. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial.
    Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ, Grobusch MP, HookVac Consortium.
    Lancet Infect Dis; 2021 Feb 06; 21(2):275-285. PubMed ID: 32926834
    [Abstract] [Full Text] [Related]

  • 8. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus.
    Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P.
    Infect Immun; 2010 Apr 06; 78(4):1552-63. PubMed ID: 20145100
    [Abstract] [Full Text] [Related]

  • 9. Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion.
    Williamson AL, Brindley PJ, Abbenante G, Datu BJ, Prociv P, Berry C, Girdwood K, Pritchard DI, Fairlie DP, Hotez PJ, Zhan B, Loukas A.
    J Infect Dis; 2003 Feb 01; 187(3):484-94. PubMed ID: 12552433
    [Abstract] [Full Text] [Related]

  • 10. Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
    Pearson MS, Pickering DA, Tribolet L, Cooper L, Mulvenna J, Oliveira LM, Bethony JM, Hotez PJ, Loukas A.
    J Infect Dis; 2010 May 15; 201(10):1561-9. PubMed ID: 20367477
    [Abstract] [Full Text] [Related]

  • 11. The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.
    Xiao S, Zhan B, Xue J, Goud GN, Loukas A, Liu Y, Williamson A, Liu S, Deumic V, Hotez P.
    Exp Parasitol; 2008 Jan 15; 118(1):32-40. PubMed ID: 17645877
    [Abstract] [Full Text] [Related]

  • 12. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.
    Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A.
    FASEB J; 2009 Sep 15; 23(9):3007-19. PubMed ID: 19380510
    [Abstract] [Full Text] [Related]

  • 13. Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus.
    Ranjit N, Zhan B, Hamilton B, Stenzel D, Lowther J, Pearson M, Gorman J, Hotez P, Loukas A.
    J Infect Dis; 2009 Mar 15; 199(6):904-12. PubMed ID: 19434933
    [Abstract] [Full Text] [Related]

  • 14. New vaccines for neglected parasitic diseases and dengue.
    Beaumier CM, Gillespie PM, Hotez PJ, Bottazzi ME.
    Transl Res; 2013 Sep 15; 162(3):144-55. PubMed ID: 23578479
    [Abstract] [Full Text] [Related]

  • 15. Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus.
    Kelleher A, Zhan B, Asojo OA.
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2013 Aug 15; 69(Pt 8):839-43. PubMed ID: 23908024
    [Abstract] [Full Text] [Related]

  • 16. Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults.
    Diemert DJ, Freire J, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J.
    PLoS Negl Trop Dis; 2017 May 15; 11(5):e0005574. PubMed ID: 28464026
    [Abstract] [Full Text] [Related]

  • 17. Advancing a vaccine to prevent hookworm disease and anemia.
    Hotez PJ, Beaumier CM, Gillespie PM, Strych U, Hayward T, Bottazzi ME.
    Vaccine; 2016 Jun 03; 34(26):3001-3005. PubMed ID: 27040400
    [Abstract] [Full Text] [Related]

  • 18. A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus.
    Ranjit N, Zhan B, Stenzel DJ, Mulvenna J, Fujiwara R, Hotez PJ, Loukas A.
    Mol Biochem Parasitol; 2008 Aug 03; 160(2):90-9. PubMed ID: 18501979
    [Abstract] [Full Text] [Related]

  • 19. Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules.
    Williamson AL, Brindley PJ, Loukas A.
    Parasitology; 2003 Feb 03; 126(Pt 2):179-85. PubMed ID: 12636356
    [Abstract] [Full Text] [Related]

  • 20. Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies.
    Plieskatt JL, Rezende WC, Olsen CM, Trefethen JM, Joshi SB, Middaugh CR, Hotez PJ, Bottazzi ME.
    Hum Vaccin Immunother; 2012 Jun 03; 8(6):765-76. PubMed ID: 22495115
    [Abstract] [Full Text] [Related]

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