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Journal Abstract Search

179 related items for PubMed ID: 25912799

  • 1. Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.
    Mahaddalkar T, Suri C, Naik PK, Lopus M.
    Eur J Pharmacol; 2015 Aug 05; 760():154-62. PubMed ID: 25912799
    [Abstract] [Full Text] [Related]

  • 2. Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.
    Pradhan M, Suri C, Choudhary S, Naik PK, Lopus M.
    J Biomol Struct Dyn; 2018 Jan 05; 36(1):195-208. PubMed ID: 27960611
    [Abstract] [Full Text] [Related]

  • 3. A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.
    Yan J, Pang Y, Sheng J, Wang Y, Chen J, Hu J, Huang L, Li X.
    Biochem Pharmacol; 2015 Sep 01; 97(1):51-61. PubMed ID: 26212540
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization.
    Lin HY, Li ZK, Bai LF, Baloch SK, Wang F, Qiu HY, Wang X, Qi JL, Yang RW, Wang XM, Yang YH.
    Biochem Pharmacol; 2015 Jul 15; 96(2):93-106. PubMed ID: 25957661
    [Abstract] [Full Text] [Related]

  • 5. CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.
    Rai A, Gupta TK, Kini S, Kunwar A, Surolia A, Panda D.
    Biochem Pharmacol; 2013 Aug 01; 86(3):378-91. PubMed ID: 23747346
    [Abstract] [Full Text] [Related]

  • 6. Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents.
    Santoshi S, Manchukonda NK, Suri C, Sharma M, Sridhar B, Joseph S, Lopus M, Kantevari S, Baitharu I, Naik PK.
    J Comput Aided Mol Des; 2015 Mar 01; 29(3):249-70. PubMed ID: 25481458
    [Abstract] [Full Text] [Related]

  • 7. beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.
    Moon DO, Kim MO, Choi YH, Kim GY.
    Cancer Lett; 2008 Jun 18; 264(2):181-91. PubMed ID: 18314257
    [Abstract] [Full Text] [Related]

  • 8. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
    Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D.
    Biochemistry; 2004 Jun 01; 43(21):6645-55. PubMed ID: 15157098
    [Abstract] [Full Text] [Related]

  • 9. Structural Basis of Noscapine Activation for Tubulin Binding.
    Oliva MA, Prota AE, Rodríguez-Salarichs J, Bennani YL, Jiménez-Barbero J, Bargsten K, Canales Á, Steinmetz MO, Díaz JF.
    J Med Chem; 2020 Aug 13; 63(15):8495-8501. PubMed ID: 32657585
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.
    Sun WX, Han HW, Yang MK, Wen ZL, Wang YS, Fu JY, Lu YT, Wang MY, Bao JX, Lu GH, Qi JL, Wang XM, Lin HY, Yang YH.
    Bioorg Med Chem; 2019 Dec 01; 27(23):115153. PubMed ID: 31648877
    [Abstract] [Full Text] [Related]

  • 11. Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine.
    Mohan L, Raghav D, Ashraf SM, Sebastian J, Rathinasamy K.
    Biomed Pharmacother; 2018 Sep 01; 105():506-517. PubMed ID: 29883946
    [Abstract] [Full Text] [Related]

  • 12. Biological evaluation and molecular modelling study of podophyllotoxin derivatives as potent inhibitors of tubulin polymerization.
    Ma Y, Fang S, Li H, Han C, Lu Y, Zhao Y, Liu Y, Zhao C.
    Chem Biol Drug Des; 2013 Jul 01; 82(1):12-21. PubMed ID: 23786349
    [Abstract] [Full Text] [Related]

  • 13. Indicine N-oxide binds to tubulin at a distinct site and inhibits the assembly of microtubules: a mechanism for its cytotoxic activity.
    Appadurai P, Rathinasamy K.
    Toxicol Lett; 2014 Feb 10; 225(1):66-77. PubMed ID: 24300171
    [Abstract] [Full Text] [Related]

  • 14. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
    Du T, Lin S, Ji M, Xue N, Liu Y, Zhang Z, Zhang K, Zhang J, Zhang Y, Wang Q, Sheng L, Li Y, Lu D, Chen X, Xu H.
    Cancer Lett; 2020 Dec 28; 495():22-32. PubMed ID: 32931884
    [Abstract] [Full Text] [Related]

  • 15. A molecular docking study of anticancer drug paclitaxel and its analogues.
    Sinha R, Vidyarthi AS, Shankaracharya.
    Indian J Biochem Biophys; 2011 Apr 28; 48(2):101-5. PubMed ID: 21682141
    [Abstract] [Full Text] [Related]

  • 16. Structures of potent anticancer compounds bound to tubulin.
    McNamara DE, Senese S, Yeates TO, Torres JZ.
    Protein Sci; 2015 Jul 28; 24(7):1164-72. PubMed ID: 25970265
    [Abstract] [Full Text] [Related]

  • 17. Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity.
    Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L.
    J Biol Chem; 2019 Nov 29; 294(48):18099-18108. PubMed ID: 31628188
    [Abstract] [Full Text] [Related]

  • 18. Development of a novel class of tubulin inhibitors with promising anticancer activities.
    Xi J, Zhu X, Feng Y, Huang N, Luo G, Mao Y, Han X, Tian W, Wang G, Han X, Luo R, Huang Z, An J.
    Mol Cancer Res; 2013 Aug 29; 11(8):856-64. PubMed ID: 23666368
    [Abstract] [Full Text] [Related]

  • 19. 3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells.
    Jiang JD, Davis AS, Middleton K, Ling YH, Perez-Soler R, Holland JF, Bekesi JG.
    Cancer Res; 1998 Dec 01; 58(23):5389-95. PubMed ID: 9850070
    [Abstract] [Full Text] [Related]

  • 20. Electrostatic contributions to colchicine binding within tubulin isotypes.
    Huzil JT, Barakat K, Tuszynski JA.
    Electromagn Biol Med; 2009 Dec 01; 28(4):355-64. PubMed ID: 20017626
    [Abstract] [Full Text] [Related]

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