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Journal Abstract Search

888 related items for PubMed ID: 25930235

  • 1. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
    Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CCY, Chang TY.
    Neurobiol Aging; 2015 Jul; 36(7):2248-2259. PubMed ID: 25930235
    [Abstract] [Full Text] [Related]

  • 2. Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.
    Murphy SR, Chang CC, Dogbevia G, Bryleva EY, Bowen Z, Hasan MT, Chang TY.
    Mol Ther; 2013 Aug; 21(8):1497-506. PubMed ID: 23774792
    [Abstract] [Full Text] [Related]

  • 3. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
    Zhang ZH, Wu QY, Zheng R, Chen C, Chen Y, Liu Q, Hoffmann PR, Ni JZ, Song GL.
    J Neurosci; 2017 Mar 01; 37(9):2449-2462. PubMed ID: 28137967
    [Abstract] [Full Text] [Related]

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  • 5. Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
    Shibuya Y, Chang CC, Huang LH, Bryleva EY, Chang TY.
    J Neurosci; 2014 Oct 22; 34(43):14484-501. PubMed ID: 25339759
    [Abstract] [Full Text] [Related]

  • 6. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.
    Neurobiol Dis; 2016 Jan 22; 85():187-205. PubMed ID: 26563932
    [Abstract] [Full Text] [Related]

  • 7. Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
    Chen Y, Zhu L, Ji L, Yang Y, Lu L, Wang X, Zhou G.
    Med Sci Monit; 2018 Dec 12; 24():9007-9018. PubMed ID: 30541014
    [Abstract] [Full Text] [Related]

  • 8. A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.
    Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.
    J Neurochem; 2011 Dec 12; 119(6):1330-40. PubMed ID: 21992552
    [Abstract] [Full Text] [Related]

  • 9. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
    Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY.
    Proc Natl Acad Sci U S A; 2010 Feb 16; 107(7):3081-6. PubMed ID: 20133765
    [Abstract] [Full Text] [Related]

  • 10. ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.
    Shibuya Y, Chang CC, Chang TY.
    Future Med Chem; 2015 Feb 16; 7(18):2451-67. PubMed ID: 26669800
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles.
    Chu J, Lauretti E, Craige CP, Praticò D.
    J Alzheimers Dis; 2014 Feb 16; 41(3):729-37. PubMed ID: 24662099
    [Abstract] [Full Text] [Related]

  • 12. Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
    España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA.
    Biol Psychiatry; 2010 Mar 15; 67(6):513-21. PubMed ID: 19664757
    [Abstract] [Full Text] [Related]

  • 13. Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.
    Dobarro M, Gerenu G, Ramírez MJ.
    Int J Neuropsychopharmacol; 2013 Nov 15; 16(10):2245-57. PubMed ID: 23768694
    [Abstract] [Full Text] [Related]

  • 14. GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.
    Gibbons GS, Banks RA, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM.
    J Neurosci; 2017 Nov 22; 37(47):11485-11494. PubMed ID: 28986461
    [Abstract] [Full Text] [Related]

  • 15. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.
    Imamura T, Yanagihara YT, Ohyagi Y, Nakamura N, Iinuma KM, Yamasaki R, Asai H, Maeda M, Murakami K, Irie K, Kira JI.
    Neurobiol Dis; 2020 Apr 22; 137():104739. PubMed ID: 31927145
    [Abstract] [Full Text] [Related]

  • 16. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
    Clausen A, Xu X, Bi X, Baudry M.
    J Alzheimers Dis; 2012 Apr 22; 30(1):183-208. PubMed ID: 22406441
    [Abstract] [Full Text] [Related]

  • 17. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
    Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M.
    Aging Cell; 2020 Feb 22; 19(2):e13069. PubMed ID: 31858697
    [Abstract] [Full Text] [Related]

  • 18. Alzheimer's disease pathological lesions activate the spleen tyrosine kinase.
    Schweig JE, Yao H, Beaulieu-Abdelahad D, Ait-Ghezala G, Mouzon B, Crawford F, Mullan M, Paris D.
    Acta Neuropathol Commun; 2017 Sep 06; 5(1):69. PubMed ID: 28877763
    [Abstract] [Full Text] [Related]

  • 19. AβPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimer's Disease.
    Bielarczyk H, Jankowska-Kulawy A, Höfling C, Ronowska A, Gul-Hinc S, Roßner S, Schliebs R, Pawelczyk T, Szutowicz A.
    J Alzheimers Dis; 2015 Sep 06; 48(4):1083-94. PubMed ID: 26402099
    [Abstract] [Full Text] [Related]

  • 20. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.
    Hopp SC, Lin Y, Oakley D, Roe AD, DeVos SL, Hanlon D, Hyman BT.
    J Neuroinflammation; 2018 Sep 18; 15(1):269. PubMed ID: 30227881
    [Abstract] [Full Text] [Related]

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