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233 related items for PubMed ID: 25960173

  • 1. Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.
    Vessillier S, Eastwood D, Fox B, Sathish J, Sethu S, Dougall T, Thorpe SJ, Thorpe R, Stebbings R.
    J Immunol Methods; 2015 Sep; 424():43-52. PubMed ID: 25960173
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  • 2. A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies.
    Bailey L, Moreno L, Manigold T, Krasniqi S, Kropshofer H, Hinton H, Singer T, Suter L, Hansel TT, Mitchell JA.
    J Pharmacol Toxicol Methods; 2013 Sep; 68(2):231-239. PubMed ID: 23280407
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  • 10. After TGN1412: recent developments in cytokine release assays.
    Stebbings R, Eastwood D, Poole S, Thorpe R.
    J Immunotoxicol; 2013 Sep; 10(1):75-82. PubMed ID: 22967038
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  • 11. "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
    Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S.
    J Immunol; 2007 Sep 01; 179(5):3325-31. PubMed ID: 17709549
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  • 16. Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety.
    MacLeod E, Rajagopal D, Vessillier S.
    J Vis Exp; 2023 Sep 15; (199):. PubMed ID: 37782084
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  • 17. An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics.
    Reed DM, Paschalaki KE, Starke RD, Mohamed NA, Sharp G, Fox B, Eastwood D, Bristow A, Ball C, Vessillier S, Hansel TT, Thorpe SJ, Randi AM, Stebbings R, Mitchell JA.
    FASEB J; 2015 Jun 15; 29(6):2595-602. PubMed ID: 25746794
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  • 18. Antibody C region influences TGN1412-like functional activity in vitro.
    Ball C, Fox B, Hufton S, Sharp G, Poole S, Stebbings R, Eastwood D, Findlay L, Parren PW, Thorpe R, Bristow A, Thorpe SJ.
    J Immunol; 2012 Dec 15; 189(12):5831-40. PubMed ID: 23150712
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  • 19. Cell contact-dependent priming and Fc interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response.
    Bartholomaeus P, Semmler LY, Bukur T, Boisguerin V, Römer PS, Tabares P, Chuvpilo S, Tyrsin DY, Matskevich A, Hengel H, Castle J, Hünig T, Kalinke U.
    J Immunol; 2014 Mar 01; 192(5):2091-8. PubMed ID: 24470499
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  • 20. Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function.
    Dudek S, Weißmüller S, Anzaghe M, Miller L, Sterr S, Hoffmann K, Hengel H, Waibler Z.
    Eur J Immunol; 2019 Jul 01; 49(7):1117-1126. PubMed ID: 31002172
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