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215 related items for PubMed ID: 25961580

  • 1. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation.
    Li W, Zhang C, Ren A, Li T, Jin R, Li G, Gu X, Shi R, Zhao Y.
    PLoS One; 2015; 10(5):e0126459. PubMed ID: 25961580
    [Abstract] [Full Text] [Related]

  • 2. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.
    Li W, Liu J, Zhao Y.
    Mol Carcinog; 2014 May; 53(5):403-12. PubMed ID: 23255458
    [Abstract] [Full Text] [Related]

  • 3. Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
    Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C.
    Biochem Cell Biol; 2019 Aug; 97(4):397-405. PubMed ID: 30475643
    [Abstract] [Full Text] [Related]

  • 4. Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway.
    Tang JC, Ren YG, Zhao J, Long F, Chen JY, Jiang Z.
    Life Sci; 2018 Jul 01; 204():71-77. PubMed ID: 29738778
    [Abstract] [Full Text] [Related]

  • 5. Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines.
    Thonsri U, Seubwai W, Waraasawapati S, Wongkham S, Boonmars T, Cha'on U, Wongkham C.
    Anticancer Res; 2020 Sep 01; 40(9):5115-5124. PubMed ID: 32878800
    [Abstract] [Full Text] [Related]

  • 6. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer.
    Bhoumik A, Fichtman B, Derossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z.
    Proc Natl Acad Sci U S A; 2008 Feb 05; 105(5):1674-9. PubMed ID: 18227516
    [Abstract] [Full Text] [Related]

  • 7. Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis.
    Zhao X, Zhu Y, Hu J, Jiang L, Li L, Jia S, Zen K.
    Sci Rep; 2018 Sep 28; 8(1):14517. PubMed ID: 30266938
    [Abstract] [Full Text] [Related]

  • 8. Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
    Yang W, Liu J, Hou L, Chen Q, Liu Y.
    Life Sci; 2021 Jan 15; 265():118796. PubMed ID: 33220292
    [Abstract] [Full Text] [Related]

  • 9. PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis.
    Zhao X, Tan F, Cao X, Cao Z, Li B, Shen Z, Tian Y.
    Acta Biochim Biophys Sin (Shanghai); 2020 Jan 02; 52(1):9-17. PubMed ID: 31867609
    [Abstract] [Full Text] [Related]

  • 10. Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.
    Yuan Q, Yu H, Chen J, Song X, Sun L.
    Exp Cell Res; 2018 Jan 01; 362(1):209-216. PubMed ID: 29155364
    [Abstract] [Full Text] [Related]

  • 11. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
    Staniforth V, Wang SY, Shyur LF, Yang NS.
    J Biol Chem; 2004 Feb 13; 279(7):5877-85. PubMed ID: 14645256
    [Abstract] [Full Text] [Related]

  • 12. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.
    Qu D, Xu XM, Zhang M, Jiang TS, Zhang Y, Li SQ.
    Mol Med Rep; 2015 Jul 13; 12(1):1305-13. PubMed ID: 25815461
    [Abstract] [Full Text] [Related]

  • 13. Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation.
    Xie X, Wang M, Mei J, Hu F, Ding F, Lv L.
    Biochem Biophys Res Commun; 2015 Nov 13; 467(2):427-33. PubMed ID: 26410533
    [Abstract] [Full Text] [Related]

  • 14. Down-regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis.
    Tao T, Su Q, Xu S, Deng J, Zhou S, Zhuang Y, Huang Y, He C, He S, Peng M, Hocher B, Yang X.
    J Cell Physiol; 2019 Mar 13; 234(3):3088-3104. PubMed ID: 30221356
    [Abstract] [Full Text] [Related]

  • 15. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
    Chiou YS, Sang S, Cheng KH, Ho CT, Wang YJ, Pan MH.
    Carcinogenesis; 2013 Jun 13; 34(6):1315-22. PubMed ID: 23385063
    [Abstract] [Full Text] [Related]

  • 16. PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis.
    Wang Y, Hao F, Nan Y, Qu L, Na W, Jia C, Chen X.
    Int J Biol Sci; 2018 Jun 13; 14(13):1883-1891. PubMed ID: 30443191
    [Abstract] [Full Text] [Related]

  • 17. Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells.
    Zhou Z, Li M, Zhang L, Zhao H, Şahin Ö, Chen J, Zhao JJ, Songyang Z, Yu D.
    Cancer Res; 2018 May 01; 78(9):2248-2261. PubMed ID: 29440169
    [Abstract] [Full Text] [Related]

  • 18. Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells.
    Chen YL, Song JJ, Chen XC, Xu W, Zhi Q, Liu YP, Xu HZ, Pan JS, Ren JL, Guleng B.
    World J Gastroenterol; 2015 Aug 14; 21(30):9093-102. PubMed ID: 26290635
    [Abstract] [Full Text] [Related]

  • 19. Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling.
    Li MY, Mi C, Wang KS, Wang Z, Zuo HX, Piao LX, Xu GH, Li X, Ma J, Jin X.
    Chem Biol Interact; 2017 Aug 25; 274():58-67. PubMed ID: 28684144
    [Abstract] [Full Text] [Related]

  • 20. Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis.
    Zhou H, Wang X, Mo L, Liu Y, He F, Zhang F, Huang KH, Wu XR.
    Oncotarget; 2016 Apr 26; 7(17):23947-60. PubMed ID: 26992222
    [Abstract] [Full Text] [Related]

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