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687 related items for PubMed ID: 25963418

  • 1. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
    Middendorp SJ, Maldifassi MC, Baur R, Sigel E.
    Neuropharmacology; 2015 Aug; 95():459-67. PubMed ID: 25963418
    [Abstract] [Full Text] [Related]

  • 2. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
    Whittemore ER, Yang W, Drewe JA, Woodward RM.
    Mol Pharmacol; 1996 Nov; 50(5):1364-75. PubMed ID: 8913369
    [Abstract] [Full Text] [Related]

  • 3. Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes.
    You H, Kozuska JL, Paulsen IM, Dunn SM.
    Neuropharmacology; 2010 Nov; 59(6):527-33. PubMed ID: 20638393
    [Abstract] [Full Text] [Related]

  • 4. The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites.
    Huang R, Chen Z, Dolan S, Schetz JA, Dillon GH.
    Neuropharmacology; 2017 Jul 15; 121():167-178. PubMed ID: 28456686
    [Abstract] [Full Text] [Related]

  • 5. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.
    Hall BJ, Chebib M, Hanrahan JR, Johnston GA.
    Eur J Pharmacol; 2004 Apr 26; 491(1):1-8. PubMed ID: 15102527
    [Abstract] [Full Text] [Related]

  • 6. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep 26; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 7. Novel positive allosteric modulators of GABAA receptors with anesthetic activity.
    Maldifassi MC, Baur R, Pierce D, Nourmahnad A, Forman SA, Sigel E.
    Sci Rep; 2016 May 20; 6():25943. PubMed ID: 27198062
    [Abstract] [Full Text] [Related]

  • 8. Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
    Pericić D, Strac DS, Jembrek MJ, Vlainić J.
    Naunyn Schmiedebergs Arch Pharmacol; 2007 May 20; 375(3):177-87. PubMed ID: 17377772
    [Abstract] [Full Text] [Related]

  • 9. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
    Tan KR, Baur R, Charon S, Goeldner M, Sigel E.
    J Neurochem; 2009 Dec 20; 111(5):1264-73. PubMed ID: 19804380
    [Abstract] [Full Text] [Related]

  • 10. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
    Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S.
    Proc Natl Acad Sci U S A; 2002 Nov 12; 99(23):15170-5. PubMed ID: 12415111
    [Abstract] [Full Text] [Related]

  • 11. A closer look at the high affinity benzodiazepine binding site on GABAA receptors.
    Sigel E, Lüscher BP.
    Curr Top Med Chem; 2011 Nov 12; 11(2):241-6. PubMed ID: 21189125
    [Abstract] [Full Text] [Related]

  • 12. Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site.
    Buhr A, Baur R, Sigel E.
    J Biol Chem; 1997 May 02; 272(18):11799-804. PubMed ID: 9115236
    [Abstract] [Full Text] [Related]

  • 13. Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
    Knoflach F, Benke D, Wang Y, Scheurer L, Lüddens H, Hamilton BJ, Carter DB, Mohler H, Benson JA.
    Mol Pharmacol; 1996 Nov 02; 50(5):1253-61. PubMed ID: 8913357
    [Abstract] [Full Text] [Related]

  • 14. Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.
    Maldifassi MC, Baur R, Sigel E.
    J Neurochem; 2016 Sep 02; 138(5):722-30. PubMed ID: 27319298
    [Abstract] [Full Text] [Related]

  • 15. Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.
    Walters RJ, Hadley SH, Morris KD, Amin J.
    Nat Neurosci; 2000 Dec 02; 3(12):1274-81. PubMed ID: 11100148
    [Abstract] [Full Text] [Related]

  • 16. Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density.
    Granja R, Gunnersen D, Wong G, Valeyev A, Skolnick P.
    J Mol Neurosci; 1997 Dec 02; 9(3):187-95. PubMed ID: 9481620
    [Abstract] [Full Text] [Related]

  • 17. Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
    Korpi ER, Seeburg PH.
    Eur J Pharmacol; 1993 Sep 15; 247(1):23-7. PubMed ID: 8258357
    [Abstract] [Full Text] [Related]

  • 18. Alterations of the benzodiazepine site of rat alpha 6 beta 2 gamma 2-GABAA receptor by replacement of several divergent amino-terminal regions with the alpha 1 counterparts.
    Im WB, Pregenzer JF, Binder JA, Alberts GL, Im HK.
    Br J Pharmacol; 1997 Feb 15; 120(4):559-64. PubMed ID: 9051290
    [Abstract] [Full Text] [Related]

  • 19. Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
    Giusti P, Ducić I, Puia G, Arban R, Walser A, Guidotti A, Costa E.
    J Pharmacol Exp Ther; 1993 Aug 15; 266(2):1018-28. PubMed ID: 8394902
    [Abstract] [Full Text] [Related]

  • 20. Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors.
    Söderhielm PC, Balle T, Bak-Nyhus S, Zhang M, Hansen KM, Ahring PK, Jensen AA.
    Biochem Pharmacol; 2018 Dec 15; 158():339-358. PubMed ID: 30121248
    [Abstract] [Full Text] [Related]

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