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224 related items for PubMed ID: 25999473

  • 1. CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain.
    Vingtdeux V, Chandakkar P, Zhao H, Blanc L, Ruiz S, Marambaud P.
    J Cell Sci; 2015 Jul 01; 128(13):2330-8. PubMed ID: 25999473
    [Abstract] [Full Text] [Related]

  • 2. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
    Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.
    J Neurosci; 2000 Mar 01; 20(5):1657-65. PubMed ID: 10684867
    [Abstract] [Full Text] [Related]

  • 3. CALHM1 and its polymorphism P86L differentially control Ca²⁺homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β.
    Moreno-Ortega AJ, Buendia I, Mouhid L, Egea J, Lucea S, Ruiz-Nuño A, López MG, Cano-Abad MF.
    Aging Cell; 2015 Dec 01; 14(6):1094-102. PubMed ID: 26416646
    [Abstract] [Full Text] [Related]

  • 4. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
    Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.
    Proc Natl Acad Sci U S A; 2003 Apr 01; 100(7):4162-7. PubMed ID: 12634421
    [Abstract] [Full Text] [Related]

  • 5. Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.
    Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.
    Biochem Cell Biol; 2016 Dec 01; 94(6):534-542. PubMed ID: 27813426
    [Abstract] [Full Text] [Related]

  • 6. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
    Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.
    J Biol Chem; 1998 Dec 04; 273(49):32730-8. PubMed ID: 9830016
    [Abstract] [Full Text] [Related]

  • 7. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.
    Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K.
    Neuroscience; 2018 Aug 10; 385():227-236. PubMed ID: 29932983
    [Abstract] [Full Text] [Related]

  • 8. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease.
    Del Campo M, Stargardt A, Veerhuis R, Reits E, Teunissen CE.
    Neurosci Lett; 2015 Mar 04; 589():47-51. PubMed ID: 25597881
    [Abstract] [Full Text] [Related]

  • 9. Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models.
    Stargardt A, Gillis J, Kamphuis W, Wiemhoefer A, Kooijman L, Raspe M, Benckhuijsen W, Drijfhout JW, Hol EM, Reits E.
    Aging Cell; 2013 Jun 04; 12(3):499-507. PubMed ID: 23534431
    [Abstract] [Full Text] [Related]

  • 10. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
    Tamboli IY, Barth E, Christian L, Siepmann M, Kumar S, Singh S, Tolksdorf K, Heneka MT, Lütjohann D, Wunderlich P, Walter J.
    J Biol Chem; 2010 Nov 26; 285(48):37405-14. PubMed ID: 20876579
    [Abstract] [Full Text] [Related]

  • 11. Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer's Disease.
    Sikanyika NL, Parkington HC, Smith AI, Kuruppu S.
    Neurochem Res; 2019 Jun 26; 44(6):1289-1296. PubMed ID: 30806879
    [Abstract] [Full Text] [Related]

  • 12. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.
    Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P.
    Cell; 2008 Jun 27; 133(7):1149-61. PubMed ID: 18585350
    [Abstract] [Full Text] [Related]

  • 13. Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease.
    Li G, Kim C, Kim J, Yoon H, Zhou H, Kim J.
    J Alzheimers Dis; 2015 Jun 27; 46(1):109-22. PubMed ID: 25720399
    [Abstract] [Full Text] [Related]

  • 14. Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.
    Sahoo BR, Panda PK, Liang W, Tang WJ, Ahuja R, Ramamoorthy A.
    J Mol Biol; 2021 Jun 25; 433(13):166993. PubMed ID: 33865867
    [Abstract] [Full Text] [Related]

  • 15. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
    Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL.
    Proc Natl Acad Sci U S A; 2003 May 13; 100(10):6221-6. PubMed ID: 12732730
    [Abstract] [Full Text] [Related]

  • 16. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
    Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.
    Am J Pathol; 2004 Apr 13; 164(4):1425-34. PubMed ID: 15039230
    [Abstract] [Full Text] [Related]

  • 17. Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease.
    Jaya Prasanthi RP, Schommer E, Thomasson S, Thompson A, Feist G, Ghribi O.
    Mech Ageing Dev; 2008 Nov 13; 129(11):649-55. PubMed ID: 18845178
    [Abstract] [Full Text] [Related]

  • 18. Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels.
    Vingtdeux V, Tanis JE, Chandakkar P, Zhao H, Dreses-Werringloer U, Campagne F, Foskett JK, Marambaud P.
    PLoS One; 2014 Nov 13; 9(11):e112484. PubMed ID: 25386646
    [Abstract] [Full Text] [Related]

  • 19. CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
    Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P.
    J Cell Sci; 2013 Mar 01; 126(Pt 5):1199-206. PubMed ID: 23345406
    [Abstract] [Full Text] [Related]

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