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203 related items for PubMed ID: 26014146

  • 1. Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
    Hussein D, Starr A, Heikal L, McNeill E, Channon KM, Brown PR, Sutton BJ, McDonnell JM, Nandi M.
    Br J Pharmacol; 2015 Aug; 172(16):4146-57. PubMed ID: 26014146
    [Abstract] [Full Text] [Related]

  • 2. Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes.
    Yoneyama T, Hatakeyama K.
    Protein Sci; 2001 Apr; 10(4):871-8. PubMed ID: 11274478
    [Abstract] [Full Text] [Related]

  • 3. Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
    Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, Hinz I, Feiler M, Müller K, Nar H.
    J Struct Biol; 2021 Mar; 213(1):107691. PubMed ID: 33387654
    [Abstract] [Full Text] [Related]

  • 4. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
    Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.
    Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
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  • 7. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
    McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.
    Free Radic Biol Med; 2015 Feb; 79():206-16. PubMed ID: 25451639
    [Abstract] [Full Text] [Related]

  • 8. GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.
    Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W.
    Circ Res; 2010 Feb 05; 106(2):328-36. PubMed ID: 19926872
    [Abstract] [Full Text] [Related]

  • 9. Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.
    Starr A, Sand CA, Heikal L, Kelly PD, Spina D, Crabtree M, Channon KM, Leiper JM, Nandi M.
    Shock; 2014 Nov 05; 42(5):432-9. PubMed ID: 25046538
    [Abstract] [Full Text] [Related]

  • 10. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
    Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM.
    J Am Coll Cardiol; 2008 Jul 08; 52(2):158-65. PubMed ID: 18598896
    [Abstract] [Full Text] [Related]

  • 11. l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex.
    Heikal L, Starr A, Hussein D, Prieto-Lloret J, Aaronson P, Dailey LA, Nandi M.
    JACC Basic Transl Sci; 2018 Jun 08; 3(3):366-377. PubMed ID: 29963647
    [Abstract] [Full Text] [Related]

  • 12. Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.
    Chuaiphichai S, Chu SM, Carnicer R, Kelly M, Bendall JK, Simon JN, Douglas G, Crabtree MJ, Casadei B, Channon KM.
    Am J Physiol Heart Circ Physiol; 2023 Apr 01; 324(4):H430-H442. PubMed ID: 36735402
    [Abstract] [Full Text] [Related]

  • 13. GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
    Tatham AL, Crabtree MJ, Warrick N, Cai S, Alp NJ, Channon KM.
    J Biol Chem; 2009 May 15; 284(20):13660-13668. PubMed ID: 19286659
    [Abstract] [Full Text] [Related]

  • 14. Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP.
    Milstien S, Jaffe H, Kowlessur D, Bonner TI.
    J Biol Chem; 1996 Aug 16; 271(33):19743-51. PubMed ID: 8702680
    [Abstract] [Full Text] [Related]

  • 15. Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production.
    Nandi M, Kelly P, Vallance P, Leiper J.
    Vasc Med; 2008 Feb 16; 13(1):29-36. PubMed ID: 18372436
    [Abstract] [Full Text] [Related]

  • 16. Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP.
    Yoneyama T, Hatakeyama K.
    J Biol Chem; 1998 Aug 07; 273(32):20102-8. PubMed ID: 9685352
    [Abstract] [Full Text] [Related]

  • 17. Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.
    Chuaiphichai S, Starr A, Nandi M, Channon KM, McNeill E.
    Vascul Pharmacol; 2016 Feb 07; 77():69-79. PubMed ID: 26276526
    [Abstract] [Full Text] [Related]

  • 18. Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?
    Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, Vásquez-Vivar J.
    Free Radic Biol Med; 2005 Feb 15; 38(4):481-91. PubMed ID: 15649650
    [Abstract] [Full Text] [Related]

  • 19. GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis.
    Kapatos G, Hirayama K, Shimoji M, Milstien S.
    J Neurochem; 1999 Feb 15; 72(2):669-75. PubMed ID: 9930739
    [Abstract] [Full Text] [Related]

  • 20. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.
    Swick L, Kapatos G.
    J Neurochem; 2006 Jun 15; 97(5):1447-55. PubMed ID: 16696853
    [Abstract] [Full Text] [Related]

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