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Journal Abstract Search

173 related items for PubMed ID: 26048791

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  • 4. Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists.
    Matsuda D, Kawamura M, Kobashi Y, Shiozawa F, Suga Y, Fusegi K, Nishimoto S, Kimura K, Miyoshi M, Takayama N, Kakinuma H, Ohtake N.
    Bioorg Med Chem; 2018 May 01; 26(8):1832-1847. PubMed ID: 29486951
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  • 7. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.
    Semple G, Lehmann J, Wong A, Ren A, Bruce M, Shin YJ, Sage CR, Morgan M, Chen WC, Sebring K, Chu ZL, Leonard JN, Al-Shamma H, Grottick AJ, Du F, Liang Y, Demarest K, Jones RM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1750-5. PubMed ID: 22264481
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  • 11. GPR119 agonists for the treatment of type 2 diabetes.
    Jones RM, Leonard JN, Buzard DJ, Lehmann J.
    Expert Opin Ther Pat; 2009 Oct 15; 19(10):1339-59. PubMed ID: 19780700
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  • 12. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
    Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM.
    J Med Chem; 2008 Sep 11; 51(17):5172-5. PubMed ID: 18698756
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  • 14. Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure.
    Harada K, Mizukami J, Watanabe T, Mori G, Ubukata M, Suwa K, Fukuda S, Negoro T, Sato M, Inaba T.
    Bioorg Med Chem Lett; 2019 Feb 01; 29(3):373-379. PubMed ID: 30587450
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  • 15. Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.
    Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T.
    Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3290-6. PubMed ID: 21536438
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  • 16. Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists.
    Zuo Z, Chen M, Shao X, Qian X, Liu X, Zhou X, Xiang J, Deng P, Li Y, Jie H, Liu C, Cen X, Xie Y, Zhao Y.
    Bioorg Med Chem Lett; 2020 Feb 15; 30(4):126855. PubMed ID: 31898998
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  • 18. Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice.
    Yoshida S, Ohishi T, Matsui T, Tanaka H, Oshima H, Yonetoku Y, Shibasaki M.
    Biochem Biophys Res Commun; 2010 Nov 12; 402(2):280-5. PubMed ID: 20937249
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  • 19. CPL207280, a Novel G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1-Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals.
    Bazydlo-Guzenda K, Buda P, Matloka M, Mach M, Stelmach F, Dzida R, Smuga D, Hucz-Kalitowska J, Teska-Kaminska M, Vialichka V, Dubiel K, Kaminska B, Wieczorek M, Pieczykolan J.
    Mol Pharmacol; 2021 Oct 12; 100(4):335-347. PubMed ID: 34349026
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