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Journal Abstract Search

375 related items for PubMed ID: 26052091

  • 1. βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.
    Kanakkanthara A, Rowe MR, Field JJ, Northcote PT, Teesdale-Spittle PH, Miller JH.
    Cancer Lett; 2015 Sep 01; 365(2):251-60. PubMed ID: 26052091
    [Abstract] [Full Text] [Related]

  • 2. Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding.
    Kanakkanthara A, Eras J, Northcote PT, Cabral F, Miller JH.
    Curr Cancer Drug Targets; 2014 Sep 01; 14(1):79-90. PubMed ID: 24245693
    [Abstract] [Full Text] [Related]

  • 3. Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.
    Kanakkanthara A, Wilmes A, O'Brate A, Escuin D, Chan A, Gjyrezi A, Crawford J, Rawson P, Kivell B, Northcote PT, Hamel E, Giannakakou P, Miller JH.
    Mol Cancer Ther; 2011 Aug 01; 10(8):1419-29. PubMed ID: 21653684
    [Abstract] [Full Text] [Related]

  • 4. βII-tubulin and βIII-tubulin mediate sensitivity to peloruside A and laulimalide, but not paclitaxel or vinblastine, in human ovarian carcinoma cells.
    Kanakkanthara A, Northcote PT, Miller JH.
    Mol Cancer Ther; 2012 Feb 01; 11(2):393-404. PubMed ID: 22180309
    [Abstract] [Full Text] [Related]

  • 5. Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
    Zúñiga MA, Alderete JB, Jaña GA, Jiménez VA.
    J Comput Aided Mol Des; 2017 Jul 01; 31(7):643-652. PubMed ID: 28597356
    [Abstract] [Full Text] [Related]

  • 6. Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.
    Gaitanos TN, Buey RM, Díaz JF, Northcote PT, Teesdale-Spittle P, Andreu JM, Miller JH.
    Cancer Res; 2004 Aug 01; 64(15):5063-7. PubMed ID: 15289305
    [Abstract] [Full Text] [Related]

  • 7. Modulation of lateral and longitudinal interdimeric interactions in microtubule models by Laulimalide and Peloruside A association: A molecular modeling approach on the mechanism of microtubule stabilizing agents.
    Zúñiga MA, Alderete JB, Jaña GA, Fernandez PA, Ramos MJ, Jiménez VA.
    Chem Biol Drug Des; 2018 May 01; 91(5):1042-1055. PubMed ID: 29316292
    [Abstract] [Full Text] [Related]

  • 8. Structural basis of microtubule stabilization by laulimalide and peloruside A.
    Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO.
    Angew Chem Int Ed Engl; 2014 Feb 03; 53(6):1621-5. PubMed ID: 24470331
    [Abstract] [Full Text] [Related]

  • 9. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.
    Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ.
    Mol Pharmacol; 2006 Nov 03; 70(5):1555-64. PubMed ID: 16887932
    [Abstract] [Full Text] [Related]

  • 10. Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells.
    Wilmes A, O'Sullivan D, Chan A, Chandrahasen C, Paterson I, Northcote PT, La Flamme AC, Miller JH.
    Cancer Chemother Pharmacol; 2011 Jul 03; 68(1):117-26. PubMed ID: 20848285
    [Abstract] [Full Text] [Related]

  • 11. Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.
    Hanna R, Maass DR, Atkinson PH, Northcote PT, Teesdale-Spittle PH, Bellows DS, Miller JH.
    Mol Biosyst; 2014 Jan 03; 10(1):110-6. PubMed ID: 24161989
    [Abstract] [Full Text] [Related]

  • 12. Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.
    Begaye A, Trostel S, Zhao Z, Taylor RE, Schriemer DC, Sackett DL.
    Cell Cycle; 2011 Oct 01; 10(19):3387-96. PubMed ID: 21926482
    [Abstract] [Full Text] [Related]

  • 13. Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells.
    Kanakkanthara A, Rawson P, Northcote PT, Miller JH.
    Pharm Res; 2012 Nov 01; 29(11):3022-32. PubMed ID: 22584948
    [Abstract] [Full Text] [Related]

  • 14. Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.
    Field JJ, Northcote PT, Paterson I, Altmann KH, Díaz JF, Miller JH.
    Int J Mol Sci; 2017 May 03; 18(5):. PubMed ID: 28467385
    [Abstract] [Full Text] [Related]

  • 15. Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.
    Best HA, Matthews JH, Heathcott RW, Hanna R, Leahy DC, Coorey NV, Bellows DS, Atkinson PH, Miller JH.
    Mol Biosyst; 2013 Nov 03; 9(11):2842-52. PubMed ID: 24056987
    [Abstract] [Full Text] [Related]

  • 16. The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.
    Nguyen TL, Xu X, Gussio R, Ghosh AK, Hamel E.
    J Chem Inf Model; 2010 Nov 22; 50(11):2019-28. PubMed ID: 21028850
    [Abstract] [Full Text] [Related]

  • 17. Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines.
    Wilmes A, Bargh K, Kelly C, Northcote PT, Miller JH.
    Mol Pharm; 2007 Nov 22; 4(2):269-80. PubMed ID: 17397239
    [Abstract] [Full Text] [Related]

  • 18. Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.
    Pera B, Razzak M, Trigili C, Pineda O, Canales A, Buey RM, Jiménez-Barbero J, Northcote PT, Paterson I, Barasoain I, Díaz JF.
    Chembiochem; 2010 Aug 16; 11(12):1669-78. PubMed ID: 20665616
    [Abstract] [Full Text] [Related]

  • 19. Non-taxoid site microtubule-stabilizing drugs work independently of tau overexpression in mouse N2a neuroblastoma cells.
    Das V, Miller JH.
    Brain Res; 2012 Dec 13; 1489():121-32. PubMed ID: 23085090
    [Abstract] [Full Text] [Related]

  • 20. Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine.
    Pineda O, Farràs J, Maccari L, Manetti F, Botta M, Vilarrasa J.
    Bioorg Med Chem Lett; 2004 Oct 04; 14(19):4825-9. PubMed ID: 15341932
    [Abstract] [Full Text] [Related]

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