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Journal Abstract Search

197 related items for PubMed ID: 26069216

  • 21. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.
    Huff MW, Telford DE.
    Trends Pharmacol Sci; 2005 Jul; 26(7):335-40. PubMed ID: 15951028
    [Abstract] [Full Text] [Related]

  • 22. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.
    Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A.
    Org Biomol Chem; 2004 May 21; 2(10):1456-70. PubMed ID: 15136801
    [Abstract] [Full Text] [Related]

  • 23. New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis.
    Hoshino T, Kouda M, Abe T, Ohashi S.
    Biosci Biotechnol Biochem; 1999 Nov 21; 63(11):2038-41. PubMed ID: 10635573
    [Abstract] [Full Text] [Related]

  • 24. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
    Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J.
    J Lipid Res; 1997 Feb 21; 38(2):373-90. PubMed ID: 9162756
    [Abstract] [Full Text] [Related]

  • 25. A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants.
    Lodeiro S, Wilson WK, Shan H, Matsuda SP.
    Org Lett; 2006 Feb 02; 8(3):439-42. PubMed ID: 16435854
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  • 29. Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.
    Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.
    J Biol Chem; 2007 Dec 07; 282(49):35457-70. PubMed ID: 17925399
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  • 30. Conversion of squalene to the pentacarbocyclic hopene.
    Reinert DJ, Balliano G, Schulz GE.
    Chem Biol; 2004 Jan 07; 11(1):121-6. PubMed ID: 15113001
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  • 31. Profound insights into squalene cyclization.
    Poralla K.
    Chem Biol; 2004 Jan 07; 11(1):12-4. PubMed ID: 15112988
    [Abstract] [Full Text] [Related]

  • 32. Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.
    Wu TK, Wang TT, Chang CH, Liu YT, Shie WS.
    Org Lett; 2008 Nov 06; 10(21):4959-62. PubMed ID: 18842050
    [Abstract] [Full Text] [Related]

  • 33. Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase.
    Viola F, Ceruti M, Cattel L, Milla P, Poralla K, Balliano G.
    Lipids; 2000 Mar 06; 35(3):297-303. PubMed ID: 10783007
    [Abstract] [Full Text] [Related]

  • 34. Analysis of the Catalytic Mechanism of Bifunctional Triterpene/Sesquarterpene Cyclase: Tyr167 Functions To Terminate Cyclization of Squalene at the Bicyclic Step.
    Tenkovskaia L, Murakami M, Okuno K, Ueda D, Sato T.
    Chembiochem; 2017 Oct 05; 18(19):1910-1913. PubMed ID: 28881085
    [Abstract] [Full Text] [Related]

  • 35. Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring.
    Winne JM, De Clercq PJ, Milanesio M, Pattison P, Viterbo D.
    Org Biomol Chem; 2008 Jun 07; 6(11):1918-25. PubMed ID: 18480904
    [Abstract] [Full Text] [Related]

  • 36. Formation of the C ring in the lanosterol biosynthesis from squalene.
    Hess BA.
    Org Lett; 2003 Jan 23; 5(2):165-7. PubMed ID: 12529131
    [Abstract] [Full Text] [Related]

  • 37. Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives.
    Viola F, Brusa P, Balliano G, Ceruti M, Boutaud O, Schuber F, Cattel L.
    Biochem Pharmacol; 1995 Sep 07; 50(6):787-96. PubMed ID: 7575639
    [Abstract] [Full Text] [Related]

  • 38. Compelling computational evidence for the concerted cyclization of the ABC rings of hopene from protonated squalene.
    Smentek L, Hess BA.
    J Am Chem Soc; 2010 Dec 08; 132(48):17111-7. PubMed ID: 21080653
    [Abstract] [Full Text] [Related]

  • 39. Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
    Wu TK, Liu YT, Chiu FH, Chang CH.
    Org Lett; 2006 Oct 12; 8(21):4691-4. PubMed ID: 17020279
    [Abstract] [Full Text] [Related]

  • 40. Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
    Wu TK, Yu MT, Liu YT, Chang CH, Wang HJ, Diau EW.
    Org Lett; 2006 Mar 30; 8(7):1319-22. PubMed ID: 16562881
    [Abstract] [Full Text] [Related]

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