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364 related items for PubMed ID: 26161529

  • 1. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
    Wang ZZ, Yang WX, Zhang Y, Zhao N, Zhang YZ, Liu YQ, Xu Y, Wilson SP, O'Donnell JM, Zhang HT, Li YF.
    Sci Rep; 2015 Jul 10; 5():11332. PubMed ID: 26161529
    [Abstract] [Full Text] [Related]

  • 2. RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.
    Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O'Donnell JM, Zhang HT, Li YF.
    Br J Pharmacol; 2013 Feb 10; 168(4):1001-14. PubMed ID: 23003922
    [Abstract] [Full Text] [Related]

  • 3. Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
    Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT.
    J Neurosci; 2011 Jan 05; 31(1):172-83. PubMed ID: 21209202
    [Abstract] [Full Text] [Related]

  • 4. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.
    Sierksma AS, van den Hove DL, Pfau F, Philippens M, Bruno O, Fedele E, Ricciarelli R, Steinbusch HW, Vanmierlo T, Prickaerts J.
    Neuropharmacology; 2014 Feb 05; 77():120-30. PubMed ID: 24067928
    [Abstract] [Full Text] [Related]

  • 5. Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice.
    Guo J, Lin P, Zhao X, Zhang J, Wei X, Wang Q, Wang C.
    Neuroscience; 2014 Mar 28; 263():1-14. PubMed ID: 24434771
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus.
    Zhang HT, Zhao Y, Huang Y, Dorairaj NR, Chandler LJ, O'Donnell JM.
    Neuropsychopharmacology; 2004 Aug 28; 29(8):1432-9. PubMed ID: 15114341
    [Abstract] [Full Text] [Related]

  • 7. Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats.
    Nagakura A, Niimura M, Takeo S.
    Br J Pharmacol; 2002 Apr 28; 135(7):1783-93. PubMed ID: 11934820
    [Abstract] [Full Text] [Related]

  • 8. Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways.
    Maher A, El Sayed N, Nafea H, Gad M.
    CNS Neurol Disord Drug Targets; 2022 Apr 28; 21(7):631-639. PubMed ID: 34397335
    [Abstract] [Full Text] [Related]

  • 9. RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in mice.
    Zhang C, Cheng Y, Wang H, Wang C, Wilson SP, Xu J, Zhang HT.
    J Alzheimers Dis; 2014 Apr 28; 38(2):269-80. PubMed ID: 23948935
    [Abstract] [Full Text] [Related]

  • 10. FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects.
    Guo H, Cheng Y, Wang C, Wu J, Zou Z, Niu B, Yu H, Wang H, Xu J.
    Neuropharmacology; 2017 Apr 28; 116():260-269. PubMed ID: 28065587
    [Abstract] [Full Text] [Related]

  • 11. The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling.
    Wang G, Chen L, Pan X, Chen J, Wang L, Wang W, Cheng R, Wu F, Feng X, Yu Y, Zhang HT, O'Donnell JM, Xu Y.
    Oncotarget; 2016 Apr 05; 7(14):17380-92. PubMed ID: 26980711
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism.
    Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'Donnell JM.
    Neuropsychopharmacology; 2000 Aug 05; 23(2):198-204. PubMed ID: 10882846
    [Abstract] [Full Text] [Related]

  • 13. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.
    Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, Conti M, O'Donnell JM.
    Neuropsychopharmacology; 2002 Oct 05; 27(4):587-95. PubMed ID: 12377395
    [Abstract] [Full Text] [Related]

  • 14. Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREB-BDNF pathway in rat model of depression through chronic unpredictable stress.
    Wang C, Guo J, Guo R.
    BMC Complement Altern Med; 2017 Jan 24; 17(1):73. PubMed ID: 28118829
    [Abstract] [Full Text] [Related]

  • 15. Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.
    Giralt A, Saavedra A, Carretón O, Xifró X, Alberch J, Pérez-Navarro E.
    Hum Mol Genet; 2011 Nov 01; 20(21):4232-47. PubMed ID: 21835884
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats.
    Cheng YF, Wang C, Lin HB, Li YF, Huang Y, Xu JP, Zhang HT.
    Psychopharmacology (Berl); 2010 Oct 01; 212(2):181-91. PubMed ID: 20640406
    [Abstract] [Full Text] [Related]

  • 17. The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.
    Wang C, Yang XM, Zhuo YY, Zhou H, Lin HB, Cheng YF, Xu JP, Zhang HT.
    Int J Neuropsychopharmacol; 2012 Jul 01; 15(6):749-66. PubMed ID: 21733236
    [Abstract] [Full Text] [Related]

  • 18. Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.
    Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A.
    Psychopharmacology (Berl); 2012 Feb 01; 219(4):1065-79. PubMed ID: 21833500
    [Abstract] [Full Text] [Related]

  • 19. cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress.
    Luo Y, Kuang S, Li H, Ran D, Yang J.
    Oncotarget; 2017 May 30; 8(22):35558-35572. PubMed ID: 28415673
    [Abstract] [Full Text] [Related]

  • 20. Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
    Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin SC.
    Sci Rep; 2017 Apr 06; 7():46165. PubMed ID: 28383060
    [Abstract] [Full Text] [Related]

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