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Journal Abstract Search

578 related items for PubMed ID: 26180030

  • 1. Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway.
    Ho CH, Hsu JL, Liu SP, Hsu LC, Chang WL, Chao CC, Guh JH.
    Prostate; 2015 Sep; 75(13):1454-66. PubMed ID: 26180030
    [Abstract] [Full Text] [Related]

  • 2. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
    Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2006 Dec; 374(3):223-33. PubMed ID: 17102938
    [Abstract] [Full Text] [Related]

  • 3. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
    Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH.
    Biochem Pharmacol; 2007 Jun 30; 74(1):10-9. PubMed ID: 17475221
    [Abstract] [Full Text] [Related]

  • 4. A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer.
    Ye PC, Leu WJ, Yeh TY, Hsu YT, Lin YC, Wei ZY, Chen YC, Chiang YC, Hsu JL, Chan SH, Hsu LC, Chern JW, Yu CW, Guh JH.
    Prostate; 2024 May 30; 84(6):605-619. PubMed ID: 38375594
    [Abstract] [Full Text] [Related]

  • 5. Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+ /K+ -ATPase internalization and tubulin acetylation.
    Leu WJ, Wang CT, Hsu JL, Chen IS, Chang HS, Guh JH.
    Prostate; 2020 Mar 30; 80(4):305-318. PubMed ID: 31905252
    [Abstract] [Full Text] [Related]

  • 6. Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
    Ling YH, Jiang JD, Holland JF, Perez-Soler R.
    Mol Pharmacol; 2002 Sep 30; 62(3):529-38. PubMed ID: 12181429
    [Abstract] [Full Text] [Related]

  • 7. Dependency of 2-methoxyestradiol-induced mitochondrial apoptosis on mitotic spindle network impairment and prometaphase arrest in human Jurkat T cells.
    Lee ST, Lee JY, Han CR, Kim YH, Jun do Y, Taub D, Kim YH.
    Biochem Pharmacol; 2015 Apr 15; 94(4):257-69. PubMed ID: 25732194
    [Abstract] [Full Text] [Related]

  • 8. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
    Chang WL, Chang CS, Chiang PC, Ho YF, Liu JF, Chang KW, Guh JH.
    Br J Pharmacol; 2010 Aug 15; 160(7):1677-89. PubMed ID: 20649571
    [Abstract] [Full Text] [Related]

  • 9. Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.
    Yu CC, Wu PJ, Hsu JL, Ho YF, Hsu LC, Chang YJ, Chang HS, Chen IS, Guh JH.
    Prostate; 2013 Jan 15; 73(2):133-45. PubMed ID: 22674285
    [Abstract] [Full Text] [Related]

  • 10. Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus.
    Han CR, Jun do Y, Woo HJ, Jeong SY, Woo MH, Kim YH.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):945-53. PubMed ID: 22197393
    [Abstract] [Full Text] [Related]

  • 11. Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
    Chan ML, Liang JW, Hsu LC, Chang WL, Lee SS, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2015 Nov 15; 388(11):1223-36. PubMed ID: 26246051
    [Abstract] [Full Text] [Related]

  • 12. Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells.
    Han CR, Jun do Y, Kim YH, Lee JY, Kim YH.
    Biochim Biophys Acta; 2013 Oct 15; 1833(10):2220-32. PubMed ID: 23707954
    [Abstract] [Full Text] [Related]

  • 13. Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.
    Viola G, Cecconet L, Leszl A, Basso G, Brun P, Salvador A, Dall'Acqua F, Diana P, Barraja P, Cirrincione G.
    Cancer Chemother Pharmacol; 2009 Nov 15; 64(6):1235-51. PubMed ID: 19363609
    [Abstract] [Full Text] [Related]

  • 14. Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer.
    Hsu JL, Lee YJ, Leu WJ, Dong YS, Pan SL, Uang BJ, Guh JH.
    J Urol; 2014 May 15; 191(5):1429-38. PubMed ID: 24316097
    [Abstract] [Full Text] [Related]

  • 15. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.
    Hasanpourghadi M, Karthikeyan C, Pandurangan AK, Looi CY, Trivedi P, Kobayashi K, Tanaka K, Wong WF, Mustafa MR.
    J Exp Clin Cancer Res; 2016 Mar 31; 35():58. PubMed ID: 27030360
    [Abstract] [Full Text] [Related]

  • 16. CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.
    Huang YT, Huang DM, Guh JH, Chen IL, Tzeng CC, Teng CM.
    J Biol Chem; 2005 Jan 28; 280(4):2771-9. PubMed ID: 15536083
    [Abstract] [Full Text] [Related]

  • 17. KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.
    Yu CC, Liu SP, Hsu JL, Hsu JT, Kudryavtsev KV, Guh JH.
    J Biomed Sci; 2015 Jan 07; 22(1):2. PubMed ID: 25563361
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.
    Jang WY, Lee JY, Lee ST, Jun do Y, Kim YH.
    Biochem Biophys Res Commun; 2014 Sep 26; 452(3):845-51. PubMed ID: 25218503
    [Abstract] [Full Text] [Related]

  • 19. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
    Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY.
    Cancer Res; 2004 Jul 01; 64(13):4621-8. PubMed ID: 15231674
    [Abstract] [Full Text] [Related]

  • 20. A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.
    Yan J, Pang Y, Sheng J, Wang Y, Chen J, Hu J, Huang L, Li X.
    Biochem Pharmacol; 2015 Sep 01; 97(1):51-61. PubMed ID: 26212540
    [Abstract] [Full Text] [Related]

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