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756 related items for PubMed ID: 26283547

  • 1. Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
    Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM.
    Biochem J; 2015 Oct 15; 471(2):255-65. PubMed ID: 26283547
    [Abstract] [Full Text] [Related]

  • 2. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis.
    Rodriguez DA, Weinlich R, Brown S, Guy C, Fitzgerald P, Dillon CP, Oberst A, Quarato G, Low J, Cripps JG, Chen T, Green DR.
    Cell Death Differ; 2016 Jan 15; 23(1):76-88. PubMed ID: 26024392
    [Abstract] [Full Text] [Related]

  • 3. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
    Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J.
    Proc Natl Acad Sci U S A; 2014 Oct 21; 111(42):15072-7. PubMed ID: 25288762
    [Abstract] [Full Text] [Related]

  • 4. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
    Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.
    Immunity; 2013 Sep 19; 39(3):443-53. PubMed ID: 24012422
    [Abstract] [Full Text] [Related]

  • 5. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
    Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM.
    Nat Commun; 2021 Apr 13; 12(1):2211. PubMed ID: 33850121
    [Abstract] [Full Text] [Related]

  • 6. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
    Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.
    Cell Death Differ; 2016 Sep 01; 23(9):1565-76. PubMed ID: 27177019
    [Abstract] [Full Text] [Related]

  • 7. The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death.
    Guida N, Laudati G, Serani A, Mascolo L, Molinaro P, Montuori P, Di Renzo G, Canzoniero LMT, Formisano L.
    Biochem Pharmacol; 2017 Oct 15; 142():229-241. PubMed ID: 28676433
    [Abstract] [Full Text] [Related]

  • 8. A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome.
    Yu X, Mao M, Liu X, Shen T, Li T, Yu H, Zhang J, Chen X, Zhao X, Zhu D.
    J Mol Med (Berl); 2020 Apr 15; 98(4):569-583. PubMed ID: 32072232
    [Abstract] [Full Text] [Related]

  • 9. Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.
    Quarato G, Guy CS, Grace CR, Llambi F, Nourse A, Rodriguez DA, Wakefield R, Frase S, Moldoveanu T, Green DR.
    Mol Cell; 2016 Feb 18; 61(4):589-601. PubMed ID: 26853145
    [Abstract] [Full Text] [Related]

  • 10. Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
    Meng Y, Davies KA, Fitzgibbon C, Young SN, Garnish SE, Horne CR, Luo C, Garnier JM, Liang LY, Cowan AD, Samson AL, Lessene G, Sandow JJ, Czabotar PE, Murphy JM.
    Nat Commun; 2021 Nov 22; 12(1):6783. PubMed ID: 34811356
    [Abstract] [Full Text] [Related]

  • 11. Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.
    Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, Lessene G, Manning G, Lucet IS, Murphy JM.
    Cell Rep; 2019 Sep 24; 28(13):3309-3319.e5. PubMed ID: 31553902
    [Abstract] [Full Text] [Related]

  • 12. RIPK1 inhibits ZBP1-driven necroptosis during development.
    Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.
    Nature; 2016 Dec 01; 540(7631):129-133. PubMed ID: 27819682
    [Abstract] [Full Text] [Related]

  • 13. Evolutionary divergence of the necroptosis effector MLKL.
    Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.
    Cell Death Differ; 2016 Jul 01; 23(7):1185-97. PubMed ID: 26868910
    [Abstract] [Full Text] [Related]

  • 14. Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.
    Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ.
    Nat Commun; 2016 Jan 28; 7():10274. PubMed ID: 26817517
    [Abstract] [Full Text] [Related]

  • 15. The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.
    Davies KA, Tanzer MC, Griffin MDW, Mok YF, Young SN, Qin R, Petrie EJ, Czabotar PE, Silke J, Murphy JM.
    Cell Death Differ; 2018 Sep 28; 25(9):1567-1580. PubMed ID: 29445128
    [Abstract] [Full Text] [Related]

  • 16. Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
    Petrie EJ, Birkinshaw RW, Koide A, Denbaum E, Hildebrand JM, Garnish SE, Davies KA, Sandow JJ, Samson AL, Gavin X, Fitzgibbon C, Young SN, Hennessy PJ, Smith PPC, Webb AI, Czabotar PE, Koide S, Murphy JM.
    Proc Natl Acad Sci U S A; 2020 Apr 14; 117(15):8468-8475. PubMed ID: 32234780
    [Abstract] [Full Text] [Related]

  • 17. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
    Jacobsen AV, Pierotti CL, Lowes KN, Au AE, Zhang Y, Etemadi N, Fitzgibbon C, Kersten WJA, Samson AL, van Delft MF, Huang DCS, Sabroux HJ, Lessene G, Silke J, Murphy JM.
    Cell Death Dis; 2022 Apr 01; 13(4):291. PubMed ID: 35365636
    [Abstract] [Full Text] [Related]

  • 18. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
    Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.
    Nat Commun; 2015 Feb 18; 6():6282. PubMed ID: 25693118
    [Abstract] [Full Text] [Related]

  • 19. ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
    Ma B, Marcotte D, Paramasivam M, Michelsen K, Wang T, Bertolotti-Ciarlet A, Jones JH, Moree B, Butko M, Salafsky J, Sun X, McKee T, Silvian LF.
    PLoS One; 2016 Feb 18; 11(11):e0165983. PubMed ID: 27832137
    [Abstract] [Full Text] [Related]

  • 20. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.
    Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.
    J Clin Invest; 2016 Nov 01; 126(11):4346-4360. PubMed ID: 27756058
    [Abstract] [Full Text] [Related]

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