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Journal Abstract Search


164 related items for PubMed ID: 26344572

  • 21. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
    Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF.
    Drug Metab Dispos; 2004 May; 32(5):505-11. PubMed ID: 15100172
    [Abstract] [Full Text] [Related]

  • 22. [Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety].
    Imai T.
    Yakugaku Zasshi; 2007 Apr; 127(4):611-9. PubMed ID: 17409690
    [Abstract] [Full Text] [Related]

  • 23. Contribution of Human Liver and Intestinal Carboxylesterases to the Hydrolysis of Selexipag In Vitro.
    Imai S, Ichikawa T, Sugiyama C, Nonaka K, Yamada T.
    J Pharm Sci; 2019 Feb; 108(2):1027-1034. PubMed ID: 30267780
    [Abstract] [Full Text] [Related]

  • 24. [Evaluation of the Oral Absorption of Ester-type Prodrugs].
    Ohura K.
    Yakugaku Zasshi; 2020 Feb; 140(3):369-376. PubMed ID: 32115554
    [Abstract] [Full Text] [Related]

  • 25. In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors.
    Thomsen R, Rasmussen HB, Linnet K, INDICES Consortium.
    Drug Metab Dispos; 2014 Jan; 42(1):126-33. PubMed ID: 24141856
    [Abstract] [Full Text] [Related]

  • 26. Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine.
    Ohura K, Tasaka K, Hashimoto M, Imai T.
    Drug Metab Dispos; 2014 Feb; 42(2):264-73. PubMed ID: 24271336
    [Abstract] [Full Text] [Related]

  • 27. Carboxylesterase in the liver and small intestine of experimental animals and human.
    Taketani M, Shii M, Ohura K, Ninomiya S, Imai T.
    Life Sci; 2007 Aug 23; 81(11):924-32. PubMed ID: 17764701
    [Abstract] [Full Text] [Related]

  • 28. Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases.
    Takani D, Takahashi M, Hosokawa M.
    Xenobiotica; 2024 Jan 23; 54(1):10-17. PubMed ID: 38142303
    [Abstract] [Full Text] [Related]

  • 29. Nonaqueous gel for the transdermal delivery of a DTPA penta-ethyl ester prodrug.
    Zhang Y, Sadgrove MP, Sueda K, Yang YT, Pacyniak EK, Kagel JR, Braun BA, Zamboni WC, Mumper RJ, Jay M.
    AAPS J; 2013 Apr 23; 15(2):523-32. PubMed ID: 23389812
    [Abstract] [Full Text] [Related]

  • 30. Species differences for stereoselective hydrolysis of propranolol prodrugs in plasma and liver.
    Yoshigae Y, Imai T, Horita A, Otagiri M.
    Chirality; 1997 Apr 23; 9(7):661-6. PubMed ID: 9366026
    [Abstract] [Full Text] [Related]

  • 31. Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues.
    Ozaki H, Sugihara K, Tamura Y, Fujino C, Watanabe Y, Uramaru N, Sone T, Ohta S, Kitamura S.
    Food Chem Toxicol; 2015 Dec 23; 86():116-23. PubMed ID: 26321725
    [Abstract] [Full Text] [Related]

  • 32. Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration.
    Imai T, Yoshigae Y, Hosokawa M, Chiba K, Otagiri M.
    J Pharmacol Exp Ther; 2003 Dec 23; 307(3):1234-42. PubMed ID: 14534358
    [Abstract] [Full Text] [Related]

  • 33. Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender.
    Shi J, Wang X, Nguyen JH, Bleske BE, Liang Y, Liu L, Zhu HJ.
    Biochem Pharmacol; 2016 Nov 01; 119():76-84. PubMed ID: 27614009
    [Abstract] [Full Text] [Related]

  • 34. Species differences in stereoselective hydrolase activity in intestinal mucosa.
    Yoshigae Y, Imai T, Horita A, Matsukane H, Otagiri M.
    Pharm Res; 1998 Apr 01; 15(4):626-31. PubMed ID: 9587961
    [Abstract] [Full Text] [Related]

  • 35. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.
    Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS.
    J Pharmacol Exp Ther; 2013 Mar 01; 344(3):665-72. PubMed ID: 23275066
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  • 36. In vitro hydrolysis and transesterification of CDP323, an α4β1/α4β7 integrin antagonist ester prodrug.
    Chanteux H, Rosa M, Delatour C, Prakash C, Smith S, Nicolas JM.
    Drug Metab Dispos; 2014 Jan 01; 42(1):153-61. PubMed ID: 24179032
    [Abstract] [Full Text] [Related]

  • 37. Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats.
    Zhu W, Song L, Zhang H, Matoney L, LeCluyse E, Yan B.
    Drug Metab Dispos; 2000 Feb 01; 28(2):186-91. PubMed ID: 10640517
    [Abstract] [Full Text] [Related]

  • 38. Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues.
    Hammid A, Fallon JK, Lassila T, Vieiro P, Balla A, Gonzalez F, Urtti A, Smith PC, Tolonen A, Honkakoski P.
    Drug Metab Dispos; 2022 Dec 01; 50(12):1483-1492. PubMed ID: 36195336
    [Abstract] [Full Text] [Related]

  • 39. Effects of alcohol on human carboxylesterase drug metabolism.
    Parker RB, Hu ZY, Meibohm B, Laizure SC.
    Clin Pharmacokinet; 2015 Jun 01; 54(6):627-38. PubMed ID: 25511794
    [Abstract] [Full Text] [Related]

  • 40. Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.
    Ohura K, Nakada Y, Kotani S, Imai T.
    J Pharm Sci; 2015 Sep 01; 104(9):3076-83. PubMed ID: 25953731
    [Abstract] [Full Text] [Related]


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