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269 related items for PubMed ID: 26456051

  • 1. SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.
    Gorgani-Firuzjaee S, Meshkani R.
    Free Radic Biol Med; 2015 Dec; 89():679-89. PubMed ID: 26456051
    [Abstract] [Full Text] [Related]

  • 2. SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells.
    Gorgani-Firuzjaee S, Khatami S, Adeli K, Meshkani R.
    Biochem Biophys Res Commun; 2015 Sep 04; 464(4):1028-1033. PubMed ID: 26188518
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells.
    Gorgani-Firuzjaee S, Adeli K, Meshkani R.
    Biochem Biophys Res Commun; 2015 Aug 21; 464(2):441-6. PubMed ID: 26123392
    [Abstract] [Full Text] [Related]

  • 4. Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.
    Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T.
    Diabetes; 2005 Jul 21; 54(7):1958-67. PubMed ID: 15983195
    [Abstract] [Full Text] [Related]

  • 5. Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.
    Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T.
    Endocrinology; 2008 Feb 21; 149(2):642-50. PubMed ID: 18039790
    [Abstract] [Full Text] [Related]

  • 6. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
    Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M.
    Endocrinology; 2003 Sep 21; 144(9):4204-14. PubMed ID: 12933696
    [Abstract] [Full Text] [Related]

  • 7. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.
    Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.
    Mol Cell Biol; 2001 Mar 21; 21(5):1633-46. PubMed ID: 11238900
    [Abstract] [Full Text] [Related]

  • 8. Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
    Ishihara H, Sasaoka T, Ishiki M, Wada T, Hori H, Kagawa S, Kobayashi M.
    Mol Endocrinol; 2002 Oct 21; 16(10):2371-81. PubMed ID: 12351701
    [Abstract] [Full Text] [Related]

  • 9. Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
    Qiu W, Federico L, Naples M, Avramoglu RK, Meshkani R, Zhang J, Tsai J, Hussain M, Dai K, Iqbal J, Kontos CD, Horie Y, Suzuki A, Adeli K.
    Hepatology; 2008 Dec 21; 48(6):1799-809. PubMed ID: 19026012
    [Abstract] [Full Text] [Related]

  • 10. Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.
    Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.
    Diabetes; 2007 Sep 21; 56(9):2235-41. PubMed ID: 17596404
    [Abstract] [Full Text] [Related]

  • 11. IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity.
    Wu C, Cui X, Huang L, Shang X, Wu B, Wang N, He K, Han Z.
    Int J Mol Sci; 2019 Jun 11; 20(11):. PubMed ID: 31212584
    [Abstract] [Full Text] [Related]

  • 12. 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway.
    Pil Hwang Y, Gyun Kim H, Choi JH, Truong Do M, Tran TP, Chun HK, Chung YC, Jeong TC, Jeong HG.
    Mol Nutr Food Res; 2013 Mar 11; 57(3):471-82. PubMed ID: 23349077
    [Abstract] [Full Text] [Related]

  • 13. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.
    Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.
    Diabetologia; 2001 Oct 11; 44(10):1258-67. PubMed ID: 11692174
    [Abstract] [Full Text] [Related]

  • 14. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.
    Ichihara Y, Wada T, Soeda Y, Ishii Y, Sasahara M, Tsuneki H, Sasaoka T.
    J Neuroendocrinol; 2013 Apr 11; 25(4):372-82. PubMed ID: 23286299
    [Abstract] [Full Text] [Related]

  • 15. SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.
    Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M.
    J Biol Chem; 2004 Apr 09; 279(15):14835-43. PubMed ID: 14744864
    [Abstract] [Full Text] [Related]

  • 16. Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.
    Ishihara H, Sasaoka T, Hori H, Wada T, Hirai H, Haruta T, Langlois WJ, Kobayashi M.
    Biochem Biophys Res Commun; 1999 Jun 24; 260(1):265-72. PubMed ID: 10381377
    [Abstract] [Full Text] [Related]

  • 17. The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin.
    Blero D, De Smedt F, Pesesse X, Paternotte N, Moreau C, Payrastre B, Erneux C.
    Biochem Biophys Res Commun; 2001 Apr 06; 282(3):839-43. PubMed ID: 11401540
    [Abstract] [Full Text] [Related]

  • 18. A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation.
    Fu CH, Lin RJ, Yu J, Chang WW, Liao GS, Chang WY, Tseng LM, Tsai YF, Yu JC, Yu AL.
    Stem Cells; 2014 Aug 06; 32(8):2048-60. PubMed ID: 24802135
    [Abstract] [Full Text] [Related]

  • 19. Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.
    Buettner R, Ottinger I, Gerhardt-Salbert C, Wrede CE, Schölmerich J, Bollheimer LC.
    Am J Physiol Endocrinol Metab; 2007 Jun 06; 292(6):E1871-8. PubMed ID: 17327370
    [Abstract] [Full Text] [Related]

  • 20. Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.
    Ikubo M, Wada T, Fukui K, Ishiki M, Ishihara H, Asano T, Tsuneki H, Sasaoka T.
    Am J Physiol Endocrinol Metab; 2009 Jan 06; 296(1):E157-64. PubMed ID: 19001549
    [Abstract] [Full Text] [Related]

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