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Journal Abstract Search

102 related items for PubMed ID: 26463129

  • 1. Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
    Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT, Miller MD, Oguto H, Patel SJ.
    Bioorg Med Chem Lett; 2015 Nov 15; 25(22):5172-7. PubMed ID: 26463129
    [Abstract] [Full Text] [Related]

  • 2. Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity.
    Stokes SS, Huynh H, Gowravaram M, Albert R, Cavero-Tomas M, Chen B, Harang J, Loch JT, Lu M, Mullen GB, Zhao S, Liu CF, Mills SD.
    Bioorg Med Chem Lett; 2011 Aug 01; 21(15):4556-60. PubMed ID: 21719282
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
    Gu W, Wang T, Maltais F, Ledford B, Kennedy J, Wei Y, Gross CH, Parsons J, Duncan L, Arends SJ, Moody C, Perola E, Green J, Charifson PS.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3693-8. PubMed ID: 22560473
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
    Wang T, Duncan L, Gu W, O'Dowd H, Wei Y, Perola E, Parsons J, Gross CH, Moody CS, Arends SJ, Charifson PS.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3699-703. PubMed ID: 22560470
    [Abstract] [Full Text] [Related]

  • 5. Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
    Surivet JP, Lange R, Hubschwerlen C, Keck W, Specklin JL, Ritz D, Bur D, Locher H, Seiler P, Strasser DS, Prade L, Kohl C, Schmitt C, Chapoux G, Ilhan E, Ekambaram N, Athanasiou A, Knezevic A, Sabato D, Chambovey A, Gaertner M, Enderlin M, Boehme M, Sippel V, Wyss P.
    Bioorg Med Chem Lett; 2012 Nov 01; 22(21):6705-11. PubMed ID: 23006603
    [Abstract] [Full Text] [Related]

  • 6. Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
    Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.
    Antimicrob Agents Chemother; 2011 Mar 01; 55(3):1088-96. PubMed ID: 21189350
    [Abstract] [Full Text] [Related]

  • 7. Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases.
    Meier TI, Yan D, Peery RB, McAllister KA, Zook C, Peng SB, Zhao G.
    FEBS J; 2008 Nov 01; 275(21):5258-71. PubMed ID: 18795946
    [Abstract] [Full Text] [Related]

  • 8. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
    Seefeld MA, Miller WH, Newlander KA, Burgess WJ, DeWolf WE, Elkins PA, Head MS, Jakas DR, Janson CA, Keller PM, Manley PJ, Moore TD, Payne DJ, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Uzinskas IN, Wallis NG, Huffman WF.
    J Med Chem; 2003 Apr 24; 46(9):1627-35. PubMed ID: 12699381
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems.
    Maruyama T, Kano Y, Yamamoto Y, Kurazono M, Iwamatsu K, Atsumi K, Shitara E.
    Bioorg Med Chem; 2007 Jan 01; 15(1):392-402. PubMed ID: 17055731
    [Abstract] [Full Text] [Related]

  • 10. A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.
    Shapiro AB, Eakin AE, Walkup GK, Rivin O.
    J Biomol Screen; 2011 Jun 01; 16(5):486-93. PubMed ID: 21398623
    [Abstract] [Full Text] [Related]

  • 11. Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
    Axten JM, Medina JR, Blackledge CW, Duquenne C, Grant SW, Bobko MA, Peng T, Miller WH, Pinckney T, Gallagher TF, Kulkarni S, Lewandowski T, Van Aller GS, Zonis R, Ward P, Campobasso N.
    Bioorg Med Chem Lett; 2012 Jun 15; 22(12):4028-32. PubMed ID: 22579486
    [Abstract] [Full Text] [Related]

  • 12. Novel antibacterial class: a series of tetracyclic derivatives.
    Hinman MM, Rosenberg TA, Balli D, Black-Schaefer C, Chovan LE, Kalvin D, Merta PJ, Nilius AM, Pratt SD, Soni NB, Wagenaar FL, Weitzberg M, Wagner R, Beutel BA.
    J Med Chem; 2006 Aug 10; 49(16):4842-56. PubMed ID: 16884296
    [Abstract] [Full Text] [Related]

  • 13. Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.
    Ribble W, Hill WE, Ochsner UA, Jarvis TC, Guiles JW, Janjic N, Bullard JM.
    Antimicrob Agents Chemother; 2010 Nov 10; 54(11):4648-57. PubMed ID: 20696870
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and antibacterial activity of novel 4''-carbamates of 6,11-di-O-methylerythromycin A.
    Wu Z, Lu Y, Luo M, He X, Xiao Y, Yang J, Pan Y, Qiu G, Xu Y, Huang W, Long P, Li R, Hu X.
    J Antibiot (Tokyo); 2010 Jul 10; 63(7):343-50. PubMed ID: 20448668
    [Abstract] [Full Text] [Related]

  • 15. Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.
    Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA.
    Bioorg Med Chem Lett; 2014 Jan 01; 24(1):360-6. PubMed ID: 24287382
    [Abstract] [Full Text] [Related]

  • 16. Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
    Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Black T, Nargund R, Meinke PT, Olsen DB, Lagrutta A, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Sherer E, Joyce LA, Wei C, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Takano H, Shibasaki M, Yajima M, Nishimura A, Shibata T, Fukuda Y.
    Bioorg Med Chem Lett; 2015 May 01; 25(9):1831-5. PubMed ID: 25851938
    [Abstract] [Full Text] [Related]

  • 17. Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids - highly potent antibacterial agents.
    Sangaraiah N, Murugan S, Poovan S, Raja R, Alagusundaram P, Ramakrishnan V, Vellasamy S.
    Eur J Med Chem; 2012 Dec 01; 58():464-9. PubMed ID: 23151322
    [Abstract] [Full Text] [Related]

  • 18. Discovery and Optimization of NAD+-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds.
    Bi F, Ma R, Ma S.
    Curr Pharm Des; 2017 Dec 01; 23(14):2117-2130. PubMed ID: 27784238
    [Abstract] [Full Text] [Related]

  • 19. Activity of gemifloxacin against Streptococcus pneumoniae and Haemophilus influenzae.
    Morrissey I, Tillotson G.
    J Antimicrob Chemother; 2004 Feb 01; 53(2):144-8. PubMed ID: 14729748
    [Abstract] [Full Text] [Related]

  • 20. Antimicrobial activity of the new macrolide flurithromycin against Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, Branhamella catarrhalis and Staphylococcus aureus.
    Nord CE, Lindmark A, Persson I.
    J Chemother; 1989 Jul 01; 1(4 Suppl):203-4. PubMed ID: 16312369
    [No Abstract] [Full Text] [Related]

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