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356 related items for PubMed ID: 26472107

  • 1. Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
    Zhao Q, Assimopoulou AN, Klauck SM, Damianakos H, Chinou I, Kretschmer N, Rios JL, Papageorgiou VP, Bauer R, Efferth T.
    Oncotarget; 2015 Nov 17; 6(36):38934-51. PubMed ID: 26472107
    [Abstract] [Full Text] [Related]

  • 2. Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways.
    Chen Y, Zheng L, Liu J, Zhou Z, Cao X, Lv X, Chen F.
    Int Immunopharmacol; 2014 Aug 17; 21(2):447-55. PubMed ID: 24905636
    [Abstract] [Full Text] [Related]

  • 3. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S.
    Mol Cancer Ther; 2005 Mar 17; 4(3):457-70. PubMed ID: 15767555
    [Abstract] [Full Text] [Related]

  • 4. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
    Jing H, Sun W, Fan J, Zhang Y, Yang J, Jia J, Li J, Guo J, Luo S, Zheng Y.
    Mol Med Rep; 2016 Apr 17; 13(4):3009-16. PubMed ID: 26935874
    [Abstract] [Full Text] [Related]

  • 5. Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.
    Ahn J, Won M, Choi JH, Kim YS, Jung CR, Im DS, Kyun ML, Lee K, Song KB, Chung KS.
    Apoptosis; 2013 Jul 17; 18(7):870-81. PubMed ID: 23546866
    [Abstract] [Full Text] [Related]

  • 6. Shikonin exerts antitumor activity in Burkitt's lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin.
    Ni F, Huang X, Chen Z, Qian W, Tong X.
    Sci Rep; 2018 Feb 20; 8(1):3317. PubMed ID: 29463831
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.
    Yu C, Mao X, Li WX.
    Biochem Biophys Res Commun; 2005 Jun 03; 331(2):391-7. PubMed ID: 15850772
    [Abstract] [Full Text] [Related]

  • 8. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
    Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C, Dent P, Grant S.
    Blood; 2005 Feb 15; 105(4):1706-16. PubMed ID: 15494423
    [Abstract] [Full Text] [Related]

  • 9. Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.
    Nam KN, Son MS, Park JH, Lee EH.
    Neuropharmacology; 2008 Oct 15; 55(5):819-25. PubMed ID: 18657551
    [Abstract] [Full Text] [Related]

  • 10. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 11. Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction.
    Lee CC, Kang JJ, Chiang BL, Wang CN, Cheng YW.
    Life Sci; 2011 Sep 12; 89(11-12):364-70. PubMed ID: 21806999
    [Abstract] [Full Text] [Related]

  • 12. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.
    Mao X, Yu CR, Li WH, Li WX.
    Cell Res; 2008 Aug 12; 18(8):879-88. PubMed ID: 18663379
    [Abstract] [Full Text] [Related]

  • 13. Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.
    Zhao Q, Kretschmer N, Bauer R, Efferth T.
    Int J Cancer; 2015 Sep 15; 137(6):1446-56. PubMed ID: 25688715
    [Abstract] [Full Text] [Related]

  • 14. Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway.
    Zhang Y, Chen HX, Zhou SY, Wang SX, Zheng K, Xu DD, Liu YT, Wang XY, Wang X, Yan HZ, Zhang L, Liu QY, Chen WQ, Wang YF.
    Mol Cancer; 2015 Mar 07; 14():56. PubMed ID: 25890196
    [Abstract] [Full Text] [Related]

  • 15. Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c‑Myc.
    Shan ZL, Zhong L, Xiao CL, Gan LG, Xu T, Song H, Yang R, Li L, Liu BZ.
    Mol Med Rep; 2017 Sep 07; 16(3):3055-3060. PubMed ID: 28713949
    [Abstract] [Full Text] [Related]

  • 16. The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.
    Yu C, Rahmani M, Dent P, Grant S.
    Exp Cell Res; 2004 May 01; 295(2):555-66. PubMed ID: 15093752
    [Abstract] [Full Text] [Related]

  • 17. Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis through ROS and caspase-dependent pathway.
    Huang WR, Zhang Y, Tang X.
    Molecules; 2014 Jun 11; 19(6):7785-97. PubMed ID: 24962386
    [Abstract] [Full Text] [Related]

  • 18. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways.
    Guo ZL, Li JZ, Ma YY, Qian D, Zhong JY, Jin MM, Huang P, Che LY, Pan B, Wang Y, Sun ZX, Liu CZ.
    BMC Cell Biol; 2018 Dec 29; 19(1):29. PubMed ID: 30594131
    [Abstract] [Full Text] [Related]

  • 19. Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.
    Liu SQ, Yu JP, Yu HG, Lv P, Chen HL.
    Dig Liver Dis; 2006 May 29; 38(5):310-8. PubMed ID: 16527552
    [Abstract] [Full Text] [Related]

  • 20. Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia.
    Ferrer I, Friguls B, Dalfó E, Planas AM.
    Acta Neuropathol; 2003 May 29; 105(5):425-37. PubMed ID: 12677442
    [Abstract] [Full Text] [Related]

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