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134 related items for PubMed ID: 2649499

  • 1. Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation.
    Mirmira RG, Tager HS.
    J Biol Chem; 1989 Apr 15; 264(11):6349-54. PubMed ID: 2649499
    [Abstract] [Full Text] [Related]

  • 2. Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects.
    Nakagawa SH, Tager HS.
    J Biol Chem; 1986 Jun 05; 261(16):7332-41. PubMed ID: 3519607
    [Abstract] [Full Text] [Related]

  • 3. Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.
    Mirmira RG, Nakagawa SH, Tager HS.
    J Biol Chem; 1991 Jan 25; 266(3):1428-36. PubMed ID: 1988428
    [Abstract] [Full Text] [Related]

  • 4. Structural determinants of ligand recognition by type I insulin-like growth factor receptors: use of semisynthetic insulin analog probes.
    Cara JF, Nakagawa SH, Tager HS.
    Endocrinology; 1988 Jun 25; 122(6):2881-7. PubMed ID: 2967179
    [Abstract] [Full Text] [Related]

  • 5. Implications of replacing peptide bonds in the COOH-terminal B chain domain of insulin by the psi (CH2-NH) linker.
    Nakagawa SH, Johansen NL, Madsen K, Schwartz TW, Tager HS.
    Int J Pept Protein Res; 1993 Dec 25; 42(6):578-84. PubMed ID: 8307689
    [Abstract] [Full Text] [Related]

  • 6. Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions.
    Shoelson SE, Lu ZX, Parlautan L, Lynch CS, Weiss MA.
    Biochemistry; 1992 Feb 18; 31(6):1757-67. PubMed ID: 1737029
    [Abstract] [Full Text] [Related]

  • 7. Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition.
    Hua QX, Shoelson SE, Weiss MA.
    Biochemistry; 1992 Dec 01; 31(47):11940-51. PubMed ID: 1445924
    [Abstract] [Full Text] [Related]

  • 8. Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.
    Záková L, Barth T, Jirácek J, Barthová J, Zórad S.
    Biochemistry; 2004 Mar 02; 43(8):2323-31. PubMed ID: 14979729
    [Abstract] [Full Text] [Related]

  • 9. Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions.
    Mirmira RG, Tager HS.
    Biochemistry; 1991 Aug 20; 30(33):8222-9. PubMed ID: 1868095
    [Abstract] [Full Text] [Related]

  • 10. Maintenance of the B-chain beta-turn in [GlyB24] insulin mutants: a steady-state fluorescence anisotropy study.
    Pittman I, Nakagawa SH, Tager HS, Steiner DF.
    Biochemistry; 1997 Mar 25; 36(12):3430-7. PubMed ID: 9131992
    [Abstract] [Full Text] [Related]

  • 11. The role of the C-terminus of the insulin B-chain in modulating structural and functional properties of the hormone.
    Leyer S, Gattner HG, Leithäuser M, Brandenburg D, Wollmer A, Höcker H.
    Int J Pept Protein Res; 1995 Nov 25; 46(5):397-407. PubMed ID: 8567184
    [Abstract] [Full Text] [Related]

  • 12. Structural integrity of the B24 site in human insulin is important for hormone functionality.
    Žáková L, Kletvíková E, Veverka V, Lepsík M, Watson CJ, Turkenburg JP, Jirácek J, Brzozowski AM.
    J Biol Chem; 2013 Apr 12; 288(15):10230-40. PubMed ID: 23447530
    [Abstract] [Full Text] [Related]

  • 13. Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.
    Pandyarajan V, Smith BJ, Phillips NB, Whittaker L, Cox GP, Wickramasinghe N, Menting JG, Wan ZL, Whittaker J, Ismail-Beigi F, Lawrence MC, Weiss MA.
    J Biol Chem; 2014 Dec 12; 289(50):34709-27. PubMed ID: 25305014
    [Abstract] [Full Text] [Related]

  • 14. Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
    Hua QX, Shoelson SE, Inouye K, Weiss MA.
    Proc Natl Acad Sci U S A; 1993 Jan 15; 90(2):582-6. PubMed ID: 8421693
    [Abstract] [Full Text] [Related]

  • 15. Role of the COOH-terminal B-chain domain in insulin-receptor interactions. Identification of perturbations involving the insulin mainchain.
    Nakagawa SH, Tager HS.
    J Biol Chem; 1987 Sep 05; 262(25):12054-8. PubMed ID: 3305501
    [Abstract] [Full Text] [Related]

  • 16. Insulin analogs with B24 or B25 phenylalanine replaced by biphenylalanine.
    Du H, Shi J, Cui D, Zhang Y.
    Acta Biochim Biophys Sin (Shanghai); 2008 Feb 05; 40(2):133-9. PubMed ID: 18235975
    [Abstract] [Full Text] [Related]

  • 17. Shortened insulin with enhanced in vitro potency.
    Casaretto M, Spoden M, Diaconescu C, Gattner HG, Zahn H, Brandenburg D, Wollmer A.
    Biol Chem Hoppe Seyler; 1987 Jun 05; 368(6):709-16. PubMed ID: 3304338
    [Abstract] [Full Text] [Related]

  • 18. Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.
    Tager H, Thomas N, Assoian R, Rubenstein A, Saekow M, Olefsky J, Kaiser ET.
    Proc Natl Acad Sci U S A; 1980 Jun 05; 77(6):3181-5. PubMed ID: 6997872
    [Abstract] [Full Text] [Related]

  • 19. Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions.
    Nakagawa SH, Tager HS.
    Biochemistry; 1992 Mar 31; 31(12):3204-14. PubMed ID: 1554705
    [Abstract] [Full Text] [Related]

  • 20. A structural switch in a mutant insulin exposes key residues for receptor binding.
    Ludvigsen S, Olsen HB, Kaarsholm NC.
    J Mol Biol; 1998 May 29; 279(1):1-7. PubMed ID: 9636695
    [Abstract] [Full Text] [Related]

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