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Journal Abstract Search

208 related items for PubMed ID: 26526102

  • 1. Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis.
    Bravo-Rodriguez K, Klopries S, Koopmans KRM, Sundermann U, Yahiaoui S, Arens J, Kushnir S, Schulz F, Sanchez-Garcia E.
    Chem Biol; 2015 Nov 19; 22(11):1425-1430. PubMed ID: 26526102
    [Abstract] [Full Text] [Related]

  • 2. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.
    Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ.
    ACS Chem Biol; 2017 Jan 20; 12(1):114-123. PubMed ID: 28103677
    [Abstract] [Full Text] [Related]

  • 3. Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.
    Sundermann U, Bravo-Rodriguez K, Klopries S, Kushnir S, Gomez H, Sanchez-Garcia E, Schulz F.
    ACS Chem Biol; 2013 Feb 15; 8(2):443-50. PubMed ID: 23181268
    [Abstract] [Full Text] [Related]

  • 4. Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase.
    Kalkreuter E, Bingham KS, Keeler AM, Lowell AN, Schmidt JJ, Sherman DH, Williams GJ.
    Nat Commun; 2021 Apr 13; 12(1):2193. PubMed ID: 33850151
    [Abstract] [Full Text] [Related]

  • 5. Rational engineering acyltransferase domain of modular polyketide synthase for expanding substrate specificity.
    Zhang W, Zhou L, Li C, Deng Z, Qu X.
    Methods Enzymol; 2019 Apr 13; 622():271-292. PubMed ID: 31155056
    [Abstract] [Full Text] [Related]

  • 6. Structural and computational insights into the substrate specificity of acyltransferase domains from modular polyketide synthases.
    Huang S, Ji H, Zheng J.
    FEBS J; 2024 Sep 13; 291(17):3839-3855. PubMed ID: 38922792
    [Abstract] [Full Text] [Related]

  • 7. Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.
    Li Y, Zhang W, Zhang H, Tian W, Wu L, Wang S, Zheng M, Zhang J, Sun C, Deng Z, Sun Y, Qu X, Zhou J.
    Angew Chem Int Ed Engl; 2018 May 14; 57(20):5823-5827. PubMed ID: 29536601
    [Abstract] [Full Text] [Related]

  • 8. Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII.
    Musiol-Kroll EM, Zubeil F, Schafhauser T, Härtner T, Kulik A, McArthur J, Koryakina I, Wohlleben W, Grond S, Williams GJ, Lee SY, Weber T.
    ACS Synth Biol; 2017 Mar 17; 6(3):421-427. PubMed ID: 28206741
    [Abstract] [Full Text] [Related]

  • 9. Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS.
    Musiol EM, Härtner T, Kulik A, Moldenhauer J, Piel J, Wohlleben W, Weber T.
    Chem Biol; 2011 Apr 22; 18(4):438-44. PubMed ID: 21513880
    [Abstract] [Full Text] [Related]

  • 10. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases.
    Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C.
    Biochemistry; 2014 Jun 17; 53(23):3796-806. PubMed ID: 24871074
    [Abstract] [Full Text] [Related]

  • 11. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase.
    Kumar P, Koppisch AT, Cane DE, Khosla C.
    J Am Chem Soc; 2003 Nov 26; 125(47):14307-12. PubMed ID: 14624579
    [Abstract] [Full Text] [Related]

  • 12. Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.
    Koryakina I, McArthur JB, Draelos MM, Williams GJ.
    Org Biomol Chem; 2013 Jul 21; 11(27):4449-58. PubMed ID: 23681002
    [Abstract] [Full Text] [Related]

  • 13. Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase.
    Englund E, Schmidt M, Nava AA, Lechner A, Deng K, Jocic R, Lin Y, Roberts J, Benites VT, Kakumanu R, Gin JW, Chen Y, Liu Y, Petzold CJ, Baidoo EEK, Northen TR, Adams PD, Katz L, Yuzawa S, Keasling JD.
    J Am Chem Soc; 2023 Apr 26; 145(16):8822-8832. PubMed ID: 37057992
    [Abstract] [Full Text] [Related]

  • 14. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
    Wang F, Wang Y, Ji J, Zhou Z, Yu J, Zhu H, Su Z, Zhang L, Zheng J.
    ACS Chem Biol; 2015 Apr 17; 10(4):1017-25. PubMed ID: 25581064
    [Abstract] [Full Text] [Related]

  • 15. Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.
    Reeves CD, Murli S, Ashley GW, Piagentini M, Hutchinson CR, McDaniel R.
    Biochemistry; 2001 Dec 25; 40(51):15464-70. PubMed ID: 11747421
    [Abstract] [Full Text] [Related]

  • 16. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J, Fu H, Cane DE, Khosla C.
    Biochemistry; 1999 Feb 02; 38(5):1643-51. PubMed ID: 9931032
    [Abstract] [Full Text] [Related]

  • 17. Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides.
    Ad O, Thuronyi BW, Chang MC.
    Proc Natl Acad Sci U S A; 2017 Jan 31; 114(5):E660-E668. PubMed ID: 28096394
    [Abstract] [Full Text] [Related]

  • 18. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.
    Chang C, Huang R, Yan Y, Ma H, Dai Z, Zhang B, Deng Z, Liu W, Qu X.
    J Am Chem Soc; 2015 Apr 01; 137(12):4183-90. PubMed ID: 25763681
    [Abstract] [Full Text] [Related]

  • 19. Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.
    Kalkreuter E, CroweTipton JM, Lowell AN, Sherman DH, Williams GJ.
    J Am Chem Soc; 2019 Feb 06; 141(5):1961-1969. PubMed ID: 30676722
    [Abstract] [Full Text] [Related]

  • 20. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases.
    Yuzawa S, Kapur S, Cane DE, Khosla C.
    Biochemistry; 2012 May 08; 51(18):3708-10. PubMed ID: 22509729
    [Abstract] [Full Text] [Related]

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