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Journal Abstract Search

176 related items for PubMed ID: 26527619

  • 1. A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
    Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N.
    Mol Cell Biol; 2016 Jan 15; 36(2):285-94. PubMed ID: 26527619
    [Abstract] [Full Text] [Related]

  • 2. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
    Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ.
    Mol Cell Biol; 2014 Apr 15; 34(7):1262-70. PubMed ID: 24449766
    [Abstract] [Full Text] [Related]

  • 3. Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.
    Tan JME, Cook ECL, van den Berg M, Scheij S, Zelcer N, Loregger A.
    Atherosclerosis; 2019 Feb 15; 281():137-142. PubMed ID: 30658189
    [Abstract] [Full Text] [Related]

  • 4. The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
    Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N.
    Circ Res; 2016 Feb 05; 118(3):410-9. PubMed ID: 26666640
    [Abstract] [Full Text] [Related]

  • 5. Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
    Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N.
    J Biol Chem; 2016 Feb 26; 291(9):4813-25. PubMed ID: 26719329
    [Abstract] [Full Text] [Related]

  • 6. Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.
    Sharpe LJ, Howe V, Scott NA, Luu W, Phan L, Berk JM, Hochstrasser M, Brown AJ.
    J Biol Chem; 2019 Feb 15; 294(7):2436-2448. PubMed ID: 30545937
    [Abstract] [Full Text] [Related]

  • 7. Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor.
    Sorrentino V, Zelcer N.
    Curr Opin Lipidol; 2012 Jun 15; 23(3):213-219. PubMed ID: 22510808
    [Abstract] [Full Text] [Related]

  • 8. The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.
    Tan JME, van der Stoel MM, van den Berg M, van Loon NM, Moeton M, Scholl E, van der Wel NN, Kovačević I, Hordijk PL, Loregger A, Huveneers S, Zelcer N.
    Cell Rep; 2020 Aug 04; 32(5):107944. PubMed ID: 32755570
    [Abstract] [Full Text] [Related]

  • 9. Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
    Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D.
    J Biol Chem; 2012 Apr 13; 287(16):12602-11. PubMed ID: 22378787
    [Abstract] [Full Text] [Related]

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  • 11. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
    Zelcer N, Hong C, Boyadjian R, Tontonoz P.
    Science; 2009 Jul 03; 325(5936):100-4. PubMed ID: 19520913
    [Abstract] [Full Text] [Related]

  • 12. The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
    Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ.
    Biochem J; 2020 Jan 31; 477(2):541-555. PubMed ID: 31904814
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.
    Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P.
    Mol Cell Biol; 2011 May 31; 31(9):1885-93. PubMed ID: 21343340
    [Abstract] [Full Text] [Related]

  • 15. Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.
    Martinelli L, Adamopoulos A, Johansson P, Wan PT, Gunnarsson J, Guo H, Boyd H, Zelcer N, Sixma TK.
    J Biol Chem; 2020 Sep 25; 295(39):13570-13583. PubMed ID: 32727844
    [Abstract] [Full Text] [Related]

  • 16. Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL).
    Sorrentino V, Scheer L, Santos A, Reits E, Bleijlevens B, Zelcer N.
    J Biol Chem; 2011 Aug 26; 286(34):30190-9. PubMed ID: 21734303
    [Abstract] [Full Text] [Related]

  • 17. The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
    Sorrentino V, Nelson JK, Maspero E, Marques ARA, Scheer L, Polo S, Zelcer N.
    J Lipid Res; 2013 Aug 26; 54(8):2174-2184. PubMed ID: 23733886
    [Abstract] [Full Text] [Related]

  • 18. Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.
    Sorrentino V, Fouchier SW, Motazacker MM, Nelson JK, Defesche JC, Dallinga-Thie GM, Kastelein JJ, Kees Hovingh G, Zelcer N.
    Eur Heart J; 2013 May 26; 34(17):1292-7. PubMed ID: 23324548
    [Abstract] [Full Text] [Related]

  • 19. Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
    Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG.
    Sci Rep; 2020 Nov 16; 10(1):19834. PubMed ID: 33199761
    [Abstract] [Full Text] [Related]

  • 20. The UPS and downs of cholesterol homeostasis.
    Sharpe LJ, Cook EC, Zelcer N, Brown AJ.
    Trends Biochem Sci; 2014 Nov 16; 39(11):527-35. PubMed ID: 25220377
    [Abstract] [Full Text] [Related]

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