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Journal Abstract Search

430 related items for PubMed ID: 26582730

  • 1. Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
    Alt A, Pendri A, Bertekap RL, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.
    J Pharmacol Exp Ther; 2016 Feb; 356(2):293-304. PubMed ID: 26582730
    [Abstract] [Full Text] [Related]

  • 2. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
    Watt ML, Schober DA, Hitchcock S, Liu B, Chesterfield AK, McKinzie D, Felder CC.
    J Pharmacol Exp Ther; 2011 Aug; 338(2):622-32. PubMed ID: 21558436
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  • 3. Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
    Khajehali E, Valant C, Jörg M, Tobin AB, Conn PJ, Lindsley CW, Sexton PM, Scammells PJ, Christopoulos A.
    Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
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  • 4. Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
    Chambon C, Jatzke C, Wegener N, Gravius A, Danysz W.
    Eur J Pharmacol; 2012 Dec 15; 697(1-3):73-80. PubMed ID: 23085025
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  • 5. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
    Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ.
    Mol Pharmacol; 2009 Mar 15; 75(3):577-88. PubMed ID: 19047481
    [Abstract] [Full Text] [Related]

  • 6. In Vivo Pharmacological Comparison of TAK-071, a Positive Allosteric Modulator of Muscarinic M1 Receptor, and Xanomeline, an Agonist of Muscarinic M1/M4 Receptor, in Rodents.
    Mandai T, Kasahara M, Kurimoto E, Tanaka M, Suzuki M, Nakatani A, Kimura H.
    Neuroscience; 2019 Aug 21; 414():60-76. PubMed ID: 31299348
    [Abstract] [Full Text] [Related]

  • 7. Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
    Bradley SJ, Molloy C, Bundgaard C, Mogg AJ, Thompson KJ, Dwomoh L, Sanger HE, Crabtree MD, Brooke SM, Sexton PM, Felder CC, Christopoulos A, Broad LM, Tobin AB, Langmead CJ.
    Mol Pharmacol; 2018 Jun 21; 93(6):645-656. PubMed ID: 29695609
    [Abstract] [Full Text] [Related]

  • 8. Dronedarone Modulates M1 and M3 Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence.
    Jayasuriya GM, Elmslie G, Burstein ES, Ellis J.
    Pharmacology; 2017 Jun 21; 99(3-4):128-138. PubMed ID: 27992867
    [Abstract] [Full Text] [Related]

  • 9. Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation.
    Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S.
    Biochemistry; 2016 Dec 27; 55(51):7073-7085. PubMed ID: 27958713
    [Abstract] [Full Text] [Related]

  • 10. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
    Smith DL, Davoren JE, Edgerton JR, Lazzaro JT, Lee CW, Neal S, Zhang L, Grimwood S.
    Mol Pharmacol; 2016 Sep 27; 90(3):177-87. PubMed ID: 27382013
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  • 12. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
    Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ.
    J Neurosci; 2008 Oct 08; 28(41):10422-33. PubMed ID: 18842902
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  • 14. Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
    Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin TP, Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L, O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S.
    J Med Chem; 2016 Jul 14; 59(13):6313-28. PubMed ID: 27275946
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  • 17. SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors.
    Loudon JM, Bromidge SM, Brown F, Clark MS, Hatcher JP, Hawkins J, Riley GJ, Noy G, Orlek BS.
    J Pharmacol Exp Ther; 1997 Dec 14; 283(3):1059-68. PubMed ID: 9399977
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  • 19. Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors.
    Messer WS, Rajeswaran WG, Cao Y, Zhang HJ, el-Assadi AA, Dockery C, Liske J, O'Brien J, Williams FE, Huang XP, Wroblewski ME, Nagy PI, Peseckis SM.
    Pharm Acta Helv; 2000 Mar 14; 74(2-3):135-40. PubMed ID: 10812950
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