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Journal Abstract Search

174 related items for PubMed ID: 26608083

  • 1. Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.
    Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski S, Ukairo O, Obach RS.
    Drug Metab Dispos; 2016 Feb; 44(2):172-9. PubMed ID: 26608083
    [Abstract] [Full Text] [Related]

  • 2. Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
    Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.
    Drug Metab Dispos; 2010 Oct; 38(10):1900-5. PubMed ID: 20595376
    [Abstract] [Full Text] [Related]

  • 3. Simplifying the Execution of HepatoPac MetID Experiments: Metabolite Profile and Intrinsic Clearance Comparisons.
    Ballard TE, Kratochwil N, Cox LM, Moen MA, Klammers F, Ekiciler A, Goetschi A, Walter I.
    Drug Metab Dispos; 2020 Sep; 48(9):804-810. PubMed ID: 32623369
    [Abstract] [Full Text] [Related]

  • 4. Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data.
    Iegre J, Hayes MA, Thompson RA, Weidolf L, Isin EM.
    Drug Metab Dispos; 2016 May; 44(5):732-40. PubMed ID: 26868617
    [Abstract] [Full Text] [Related]

  • 5. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.
    Liu Y, Wei J, Lu J, Lei D, Yan S, Li X.
    Mater Sci Eng C Mater Biol Appl; 2016 Jun; 63():475-84. PubMed ID: 27040241
    [Abstract] [Full Text] [Related]

  • 6. Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story.
    Aratyn-Schaus Y, Ramanathan R.
    Bioanalysis; 2016 Aug; 8(16):1645-62. PubMed ID: 27460981
    [Abstract] [Full Text] [Related]

  • 7. Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.
    Ballard TE, Orozco CC, Obach RS.
    Drug Metab Dispos; 2014 May; 42(5):899-902. PubMed ID: 24608634
    [Abstract] [Full Text] [Related]

  • 8. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 9. In Vitro Metabolism of Slowly Cleared G Protein-Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism.
    Kamel A, Bowlin S, Hosea N, Arkilo D, Laurenza A.
    Drug Metab Dispos; 2021 Feb; 49(2):121-132. PubMed ID: 33273044
    [Abstract] [Full Text] [Related]

  • 10. Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog.
    Seddon T, Michelle I, Chenery RJ.
    Biochem Pharmacol; 1989 May 15; 38(10):1657-65. PubMed ID: 2730679
    [Abstract] [Full Text] [Related]

  • 11. Evaluation of the metabolism of propranolol by linear ion trap technology in mouse, rat, dog, monkey, and human cryopreserved hepatocytes.
    Baughman TM, Talarico CL, Soglia JR.
    Rapid Commun Mass Spectrom; 2009 Jul 15; 23(14):2146-50. PubMed ID: 19517456
    [Abstract] [Full Text] [Related]

  • 12. From known knowns to known unknowns: predicting in vivo drug metabolites.
    Pelkonen O, Tolonen A, Korjamo T, Turpeinen M, Raunio H.
    Bioanalysis; 2009 May 15; 1(2):393-414. PubMed ID: 21083174
    [Abstract] [Full Text] [Related]

  • 13. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 15; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.
    Dean BJ, Chang S, Silva Elipe MV, Xia YQ, Braun M, Soli E, Zhao Y, Franklin RB, Karanam B.
    Drug Metab Dispos; 2007 Feb 15; 35(2):283-92. PubMed ID: 17132765
    [Abstract] [Full Text] [Related]

  • 15. In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
    Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB.
    J Pharmacol Exp Ther; 2012 Oct 15; 343(1):134-44. PubMed ID: 22776955
    [Abstract] [Full Text] [Related]

  • 16. Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model.
    Cassidy KC, Yi P.
    Xenobiotica; 2018 Dec 15; 48(12):1192-1205. PubMed ID: 29143555
    [Abstract] [Full Text] [Related]

  • 17. In vitro species comparisons and metabolite identification.
    Dow P.
    Curr Protoc Pharmacol; 2006 Oct 15; Chapter 7():Unit7.10. PubMed ID: 22294177
    [Abstract] [Full Text] [Related]

  • 18. Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species.
    Uusitalo J, Turpeinen M, Tolonen A, Koskimies P, Lammintausta R, Pelkonen O.
    Drug Metab Pers Ther; 2016 Mar 15; 31(1):35-40. PubMed ID: 26581074
    [Abstract] [Full Text] [Related]

  • 19. Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures.
    Hewitt NJ, Bühring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D.
    Drug Metab Dispos; 2001 Jul 15; 29(7):1042-50. PubMed ID: 11408372
    [Abstract] [Full Text] [Related]

  • 20. Application of chimeric mice with humanized liver for study of human-specific drug metabolism.
    Bateman TJ, Reddy VG, Kakuni M, Morikawa Y, Kumar S.
    Drug Metab Dispos; 2014 Jun 15; 42(6):1055-65. PubMed ID: 24700822
    [Abstract] [Full Text] [Related]

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