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120 related items for PubMed ID: 26653539

  • 1. Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity.
    Trapella C, Voltan R, Melloni E, Tisato V, Celeghini C, Bianco S, Fantinati A, Salvadori S, Guerrini R, Secchiero P, Zauli G.
    J Med Chem; 2016 Jan 14; 59(1):147-56. PubMed ID: 26653539
    [Abstract] [Full Text] [Related]

  • 2. Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer.
    Roh JL, Park JY, Kim EH, Jang HJ, Kwon M.
    Cancer Lett; 2016 Feb 01; 371(1):20-9. PubMed ID: 26607904
    [Abstract] [Full Text] [Related]

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  • 4. Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.
    Stockwin LH, Yu SX, Borgel S, Hancock C, Wolfe TL, Phillips LR, Hollingshead MG, Newton DL.
    Int J Cancer; 2010 Dec 01; 127(11):2510-9. PubMed ID: 20533281
    [Abstract] [Full Text] [Related]

  • 5. Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
    Pathak RK, Marrache S, Harn DA, Dhar S.
    ACS Chem Biol; 2014 May 16; 9(5):1178-87. PubMed ID: 24617941
    [Abstract] [Full Text] [Related]

  • 6. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.
    Kumar A, Kant S, Singh SM.
    Chem Biol Interact; 2012 Jul 30; 199(1):29-37. PubMed ID: 22705712
    [Abstract] [Full Text] [Related]

  • 7. Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
    Neveu MA, De Preter G, Joudiou N, Bol A, Brender JR, Saito K, Kishimoto S, Grégoire V, Jordan BF, Krishna MC, Feron O, Gallez B.
    Oncotarget; 2016 Dec 06; 7(49):81741-81749. PubMed ID: 28082726
    [Abstract] [Full Text] [Related]

  • 8. Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy.
    Wei G, Sun J, Luan W, Hou Z, Wang S, Cui S, Cheng M, Liu Y.
    J Med Chem; 2019 Oct 10; 62(19):8760-8772. PubMed ID: 31509699
    [Abstract] [Full Text] [Related]

  • 9. Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation.
    Zhou X, Chen R, Yu Z, Li R, Li J, Zhao X, Song S, Liu J, Huang G.
    Mol Cancer; 2015 Mar 19; 14():63. PubMed ID: 25888721
    [Abstract] [Full Text] [Related]

  • 10. Effect of dichloroacetate on Lewis lung carcinoma growth and metastasis.
    Kolesnik DL, Pyaskovskaya ON, Boychuk IV, Dasyukevich OI, Melnikov OR, Tarasov AS, Solyanik GI.
    Exp Oncol; 2015 Jun 19; 37(2):126-9. PubMed ID: 26112940
    [Abstract] [Full Text] [Related]

  • 11. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.
    Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW.
    Biomaterials; 2018 Sep 19; 176():94-105. PubMed ID: 29870900
    [Abstract] [Full Text] [Related]

  • 12. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
    Ferrarini MG, Nisimura LM, Girard RMBM, Alencar MB, Fragoso MSI, Araújo-Silva CA, Veiga AA, Abud APR, Nardelli SC, Vommaro RC, Silber AM, France-Sagot M, Ávila AR.
    mSphere; 2021 Jan 06; 6(1):. PubMed ID: 33408226
    [Abstract] [Full Text] [Related]

  • 13. Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.
    Voltan R, Rimondi E, Melloni E, Gilli P, Bertolasi V, Casciano F, Rigolin GM, Zauli G, Secchiero P.
    Oncotarget; 2016 Apr 05; 7(14):18965-77. PubMed ID: 26959881
    [Abstract] [Full Text] [Related]

  • 14. The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathway.
    Agnoletto C, Brunelli L, Melloni E, Pastorelli R, Casciano F, Rimondi E, Rigolin GM, Cuneo A, Secchiero P, Zauli G.
    Oncotarget; 2015 Feb 10; 6(4):2385-96. PubMed ID: 25544776
    [Abstract] [Full Text] [Related]

  • 15. Targeting of two aspects of metabolism in breast cancer treatment.
    Gang BP, Dilda PJ, Hogg PJ, Blackburn AC.
    Cancer Biol Ther; 2014 Feb 10; 15(11):1533-41. PubMed ID: 25482950
    [Abstract] [Full Text] [Related]

  • 16. Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment.
    Ruggieri V, Agriesti F, Scrima R, Laurenzana I, Perrone D, Tataranni T, Mazzoccoli C, Lo Muzio L, Capitanio N, Piccoli C.
    Oncotarget; 2015 Jan 20; 6(2):1217-30. PubMed ID: 25544754
    [Abstract] [Full Text] [Related]

  • 17. Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.
    Ovcharenko D, Chitjian C, Kashkin A, Fanelli A, Ovcharenko V.
    Cancer Biol Ther; 2019 Jan 20; 20(9):1281-1289. PubMed ID: 31234707
    [Abstract] [Full Text] [Related]

  • 18. Hypoxia enhances antitumor activity of dichloroacetate.
    Kolesnik DL, Pyaskovskaya ON, Boichuk IV, Solyanik GI.
    Exp Oncol; 2014 Dec 20; 36(4):231-5. PubMed ID: 25537215
    [Abstract] [Full Text] [Related]

  • 19. Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.
    Kluza J, Corazao-Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, de Lassalle EM, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P.
    Cancer Res; 2012 Oct 01; 72(19):5035-47. PubMed ID: 22865452
    [Abstract] [Full Text] [Related]

  • 20. Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.
    Vella S, Conti M, Tasso R, Cancedda R, Pagano A.
    Int J Cancer; 2012 Apr 01; 130(7):1484-93. PubMed ID: 21557214
    [Abstract] [Full Text] [Related]

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