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Journal Abstract Search

313 related items for PubMed ID: 26812660

  • 1. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
    Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW.
    ChemMedChem; 2016 Feb 17; 11(4):367-73. PubMed ID: 26812660
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists.
    Schwardt O, Rabbani S, Hartmann M, Abgottspon D, Wittwer M, Kleeb S, Zalewski A, Smieško M, Cutting B, Ernst B.
    Bioorg Med Chem; 2011 Nov 01; 19(21):6454-73. PubMed ID: 21962988
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  • 4. FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
    Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B.
    J Med Chem; 2010 Dec 23; 53(24):8627-41. PubMed ID: 21105658
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  • 6. Target Selectivity of FimH Antagonists.
    Scharenberg M, Schwardt O, Rabbani S, Ernst B.
    J Med Chem; 2012 Nov 26; 55(22):9810-6. PubMed ID: 23088608
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  • 7. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
    Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.
    Nature; 2017 Jun 22; 546(7659):528-532. PubMed ID: 28614296
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  • 8. Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.
    Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ.
    Proc Natl Acad Sci U S A; 2018 Mar 20; 115(12):E2819-E2828. PubMed ID: 29507247
    [Abstract] [Full Text] [Related]

  • 9. Antiadhesive natural products against uropathogenic E. coli: What can we learn from cranberry extract?
    Scharf B, Schmidt TJ, Rabbani S, Stork C, Dobrindt U, Sendker J, Ernst B, Hensel A.
    J Ethnopharmacol; 2020 Jul 15; 257():112889. PubMed ID: 32311481
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  • 10. Synthesis and evaluation of thiomannosides, potent and orally active FimH inhibitors.
    Sattigeri JA, Garg M, Bhateja P, Soni A, Rauf ARA, Gupta M, Deshmukh MS, Jain T, Alekar N, Barman TK, Jha P, Chaira T, Bambal RB, Upadhyay DJ, Nishi T.
    Bioorg Med Chem Lett; 2018 Sep 15; 28(17):2993-2997. PubMed ID: 30017316
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  • 12. Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
    Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.
    J Med Chem; 2010 Jun 24; 53(12):4779-92. PubMed ID: 20507142
    [Abstract] [Full Text] [Related]

  • 13. Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.
    Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW.
    J Med Chem; 2012 Apr 26; 55(8):3945-59. PubMed ID: 22449031
    [Abstract] [Full Text] [Related]

  • 14. In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherichia coli: A Combined in Vivo, ex Vivo, and in Vitro Study of an Extract from Vaccinium macrocarpon.
    Rafsanjany N, Senker J, Brandt S, Dobrindt U, Hensel A.
    J Agric Food Chem; 2015 Oct 14; 63(40):8804-18. PubMed ID: 26330108
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  • 15. Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation.
    Shen XF, Ren LB, Teng Y, Zheng S, Yang XL, Guo XJ, Wang XY, Sha KH, Li N, Xu GY, Tian HW, Wang XY, Liu XK, Li J, Huang N.
    Food Chem Toxicol; 2014 Oct 14; 72():204-11. PubMed ID: 25051393
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  • 16. Proposed dual antagonist approach for the prevention and treatment of urinary tract infections caused by uropathogenic Escherichia coli.
    Ribić R, Meštrović T, Neuberg M, Kozina G.
    Med Hypotheses; 2019 Mar 14; 124():17-20. PubMed ID: 30798908
    [Abstract] [Full Text] [Related]

  • 17. Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.
    Mydock-McGrane LK, Cusumano ZT, Janetka JW.
    Expert Opin Ther Pat; 2016 Mar 14; 26(2):175-97. PubMed ID: 26651364
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  • 18. A flow cytometry-based assay for screening FimH antagonists.
    Scharenberg M, Abgottspon D, Cicek E, Jiang X, Schwardt O, Rabbani S, Ernst B.
    Assay Drug Dev Technol; 2011 Oct 14; 9(5):455-64. PubMed ID: 21675870
    [Abstract] [Full Text] [Related]

  • 19. Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.
    Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner JS, Klein R, Kalas V, Crowley J, Rath NP, Hultgren SJ, Janetka JW.
    J Med Chem; 2016 Oct 27; 59(20):9390-9408. PubMed ID: 27689912
    [Abstract] [Full Text] [Related]

  • 20. Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin.
    Touaibia M, Krammer EM, Shiao TC, Yamakawa N, Wang Q, Glinschert A, Papadopoulos A, Mousavifar L, Maes E, Oscarson S, Vergoten G, Lensink MF, Roy R, Bouckaert J.
    Molecules; 2017 Jul 03; 22(7):. PubMed ID: 28671638
    [Abstract] [Full Text] [Related]

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