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Journal Abstract Search

1078 related items for PubMed ID: 26843616

  • 1. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.
    Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.
    Oncotarget; 2016 Feb 23; 7(8):9250-70. PubMed ID: 26843616
    [Abstract] [Full Text] [Related]

  • 2. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.
    J Thorac Cardiovasc Surg; 2014 Jan 23; 147(1):508-16. PubMed ID: 24094913
    [Abstract] [Full Text] [Related]

  • 3. GANT-61 and GDC-0449 induce apoptosis of prostate cancer stem cells through a GLI-dependent mechanism.
    Tong W, Qiu L, Qi M, Liu J, Hu K, Lin W, Huang Y, Fu J.
    J Cell Biochem; 2018 Apr 23; 119(4):3641-3652. PubMed ID: 29231999
    [Abstract] [Full Text] [Related]

  • 4. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.
    Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S.
    Cancer Res; 2012 Oct 01; 72(19):5048-59. PubMed ID: 22875023
    [Abstract] [Full Text] [Related]

  • 5. Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer.
    Jeng KS, Jeng CJ, Sheen IS, Wu SH, Lu SJ, Wang CH, Chang CF.
    Int J Mol Sci; 2018 May 05; 19(5):. PubMed ID: 29734730
    [Abstract] [Full Text] [Related]

  • 6. Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss.
    Kohara Y, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.
    Int J Mol Sci; 2020 Apr 15; 21(8):. PubMed ID: 32326611
    [Abstract] [Full Text] [Related]

  • 7. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.
    He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, Zhao H, Zhao L, Jiang Q, Yu Z, Jin F, Mi X, Wang E, Cui Z, Fu L, Chen J, Wei M.
    Clin Sci (Lond); 2015 Nov 15; 129(9):809-22. PubMed ID: 26201092
    [Abstract] [Full Text] [Related]

  • 8. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.
    Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.
    PLoS One; 2013 Nov 15; 8(7):e67431. PubMed ID: 23861764
    [Abstract] [Full Text] [Related]

  • 9. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
    Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F.
    Oncotarget; 2016 Feb 09; 7(6):7134-48. PubMed ID: 26784250
    [Abstract] [Full Text] [Related]

  • 10. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
    Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.
    Cancer Lett; 2013 Oct 10; 339(2):185-94. PubMed ID: 23791879
    [Abstract] [Full Text] [Related]

  • 11. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
    Tian N, Wu H, Zhang H, Yang D, Lv L, Yang Z, Zhang T, Quan D, Zhou L, Xie Y, Xu Y, Wei N, Zhang J, Chen M, Schmitz JC, Tian Y, Wu S.
    Bioorg Med Chem; 2020 Aug 15; 28(16):115584. PubMed ID: 32690258
    [Abstract] [Full Text] [Related]

  • 12. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.
    Dagklis A, Demeyer S, De Bie J, Radaelli E, Pauwels D, Degryse S, Gielen O, Vicente C, Vandepoel R, Geerdens E, Uyttebroeck A, Boeckx N, de Bock CE, Cools J.
    Blood; 2016 Dec 08; 128(23):2642-2654. PubMed ID: 27694322
    [Abstract] [Full Text] [Related]

  • 13. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
    Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.
    Oncotarget; 2011 Aug 08; 2(8):638-45. PubMed ID: 21860067
    [Abstract] [Full Text] [Related]

  • 14. Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells.
    Okabe S, Tauchi T, Tanaka Y, Katagiri S, Ohyashiki K.
    Stem Cells Dev; 2012 Nov 01; 21(16):2939-48. PubMed ID: 22642671
    [Abstract] [Full Text] [Related]

  • 15. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
    Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.
    J Steroid Biochem Mol Biol; 2014 Jan 01; 139():7-15. PubMed ID: 24063979
    [Abstract] [Full Text] [Related]

  • 16. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
    Li QR, Zhao H, Zhang XS, Lang H, Yu K.
    Acta Pharmacol Sin; 2019 Feb 01; 40(2):257-267. PubMed ID: 29777201
    [Abstract] [Full Text] [Related]

  • 17. Gli as a novel therapeutic target in malignant pleural mesothelioma.
    Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B.
    PLoS One; 2013 Feb 01; 8(3):e57346. PubMed ID: 23483902
    [Abstract] [Full Text] [Related]

  • 18. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.
    Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.
    Int J Cancer; 2013 Apr 01; 132(7):1516-24. PubMed ID: 22949014
    [Abstract] [Full Text] [Related]

  • 19. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.
    Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, Shankar S.
    Cancer Lett; 2013 Mar 01; 330(1):22-32. PubMed ID: 23200667
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties.
    Wang F, Stappenbeck F, Parhami F.
    Cells; 2019 May 27; 8(5):. PubMed ID: 31137846
    [Abstract] [Full Text] [Related]

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