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334 related items for PubMed ID: 26935874

  • 1. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
    Jing H, Sun W, Fan J, Zhang Y, Yang J, Jia J, Li J, Guo J, Luo S, Zheng Y.
    Mol Med Rep; 2016 Apr; 13(4):3009-16. PubMed ID: 26935874
    [Abstract] [Full Text] [Related]

  • 2. Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells.
    Chang IC, Huang YJ, Chiang TI, Yeh CW, Hsu LS.
    Biol Pharm Bull; 2010 Apr; 33(5):816-24. PubMed ID: 20460760
    [Abstract] [Full Text] [Related]

  • 3. Deltonin induces apoptosis in MDA‑MB‑231 human breast cancer cells via reactive oxygen species‑mediated mitochondrial dysfunction and ERK/AKT signaling pathways.
    Zhang S, He Y, Tong Q, Chen Q, Wu X, Huang W.
    Mol Med Rep; 2013 Mar; 7(3):1038-44. PubMed ID: 23314115
    [Abstract] [Full Text] [Related]

  • 4. Novel multiple apoptotic mechanism of shikonin in human glioma cells.
    Chen CH, Lin ML, Ong PL, Yang JT.
    Ann Surg Oncol; 2012 Sep; 19(9):3097-106. PubMed ID: 22446899
    [Abstract] [Full Text] [Related]

  • 5. Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis through ROS and caspase-dependent pathway.
    Huang WR, Zhang Y, Tang X.
    Molecules; 2014 Jun 11; 19(6):7785-97. PubMed ID: 24962386
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  • 7. Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells.
    Yingkun N, Lvsong Z, Huimin Y.
    Can J Physiol Pharmacol; 2010 Dec 11; 88(12):1138-46. PubMed ID: 21164560
    [Abstract] [Full Text] [Related]

  • 8. Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.
    Ahn J, Won M, Choi JH, Kim YS, Jung CR, Im DS, Kyun ML, Lee K, Song KB, Chung KS.
    Apoptosis; 2013 Jul 11; 18(7):870-81. PubMed ID: 23546866
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
    Zhao Q, Assimopoulou AN, Klauck SM, Damianakos H, Chinou I, Kretschmer N, Rios JL, Papageorgiou VP, Bauer R, Efferth T.
    Oncotarget; 2015 Nov 17; 6(36):38934-51. PubMed ID: 26472107
    [Abstract] [Full Text] [Related]

  • 10. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.
    Mao X, Yu CR, Li WH, Li WX.
    Cell Res; 2008 Aug 17; 18(8):879-88. PubMed ID: 18663379
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  • 13. Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling.
    Li MY, Mi C, Wang KS, Wang Z, Zuo HX, Piao LX, Xu GH, Li X, Ma J, Jin X.
    Chem Biol Interact; 2017 Aug 25; 274():58-67. PubMed ID: 28684144
    [Abstract] [Full Text] [Related]

  • 14. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways.
    Ying TH, Chen CW, Hsiao YP, Hung SJ, Chung JG, Yang JH.
    Anticancer Res; 2013 Oct 25; 33(10):4411-20. PubMed ID: 24123010
    [Abstract] [Full Text] [Related]

  • 15. Apoptosis is induced by shikonin through the mitochondrial signaling pathway.
    Tang X, Zhang C, Wei J, Fang Y, Zhao R, Yu J.
    Mol Med Rep; 2016 Apr 25; 13(4):3668-74. PubMed ID: 26935754
    [Abstract] [Full Text] [Related]

  • 16. Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.
    Hsu PC, Huang YT, Tsai ML, Wang YJ, Lin JK, Pan MH.
    J Agric Food Chem; 2004 Oct 06; 52(20):6330-7. PubMed ID: 15453709
    [Abstract] [Full Text] [Related]

  • 17. Naja nigricollis CMS-9 enhances the mitochondria-mediated death pathway in adaphostin-treated human leukaemia U937 cells.
    Chen YJ, Wang JJ, Chang LS.
    Clin Exp Pharmacol Physiol; 2011 Nov 06; 38(11):755-63. PubMed ID: 21824174
    [Abstract] [Full Text] [Related]

  • 18. Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.
    Liu J, Li Q, Liu Z, Lin L, Zhang X, Cao M, Jiang J.
    Oncol Rep; 2016 Jun 06; 35(6):3363-70. PubMed ID: 27004568
    [Abstract] [Full Text] [Related]

  • 19. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 20. Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.
    Lee MJ, Kao SH, Hunag JE, Sheu GT, Yeh CW, Hseu YC, Wang CJ, Hsu LS.
    Chem Biol Interact; 2014 Mar 25; 211():44-53. PubMed ID: 24463199
    [Abstract] [Full Text] [Related]

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