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Journal Abstract Search

138 related items for PubMed ID: 26951750

  • 21. The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion.
    Tazzari PL, Tabellini G, Bortul R, Papa V, Evangelisti C, Grafone T, Martinelli G, McCubrey JA, Martelli AM.
    Leukemia; 2007 May; 21(5):886-96. PubMed ID: 17361225
    [Abstract] [Full Text] [Related]

  • 22. Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines.
    Attias-Geva Z, Bentov I, Fishman A, Werner H, Bruchim I.
    Gynecol Oncol; 2011 May 01; 121(2):383-9. PubMed ID: 21295335
    [Abstract] [Full Text] [Related]

  • 23. Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells.
    Isebaert SF, Swinnen JV, McBride WH, Haustermans KM.
    Int J Radiat Oncol Biol Phys; 2011 Sep 01; 81(1):239-47. PubMed ID: 21816290
    [Abstract] [Full Text] [Related]

  • 24. N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
    Oguro Y, Miyamoto N, Takagi T, Okada K, Awazu Y, Miki H, Hori A, Kamiyama K, Imamura S.
    Bioorg Med Chem; 2010 Oct 15; 18(20):7150-63. PubMed ID: 20833551
    [Abstract] [Full Text] [Related]

  • 25. Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
    Williamson DS, Smith GP, Mikkelsen GK, Jensen T, Acheson-Dossang P, Badolo L, Bedford ST, Chell V, Chen IJ, Dokurno P, Hentzer M, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Wang Y, Christensen KV.
    J Med Chem; 2021 Jul 22; 64(14):10312-10332. PubMed ID: 34184879
    [Abstract] [Full Text] [Related]

  • 26. Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
    Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T.
    Bioorg Med Chem; 2017 Aug 15; 25(16):4259-4264. PubMed ID: 28662963
    [Abstract] [Full Text] [Related]

  • 27. Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells.
    Cunningham MP, Thomas H, Marks C, Green M, Fan Z, Modjtahedi H.
    Int J Oncol; 2008 Nov 15; 33(5):1107-13. PubMed ID: 18949375
    [Abstract] [Full Text] [Related]

  • 28. The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.
    Maiso P, Ocio EM, Garayoa M, Montero JC, Hofmann F, García-Echeverría C, Zimmermann J, Pandiella A, San Miguel JF.
    Br J Haematol; 2008 May 15; 141(4):470-82. PubMed ID: 18341634
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  • 30. RBx10080307, a dual EGFR/IGF-1R inhibitor for anticancer therapy.
    Tandon R, Senthil V, Nithya D, Pamidiboina V, Kumar A, Malik S, Chaira T, Diwan M, Gupta P, Venkataramanan R, Malik R, Das B, Dastidar SG, Cliffe I, Ray A, Bhatnagar PK.
    Eur J Pharmacol; 2013 Jul 05; 711(1-3):19-26. PubMed ID: 23639757
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  • 32. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
    Caldwell JJ, Davies TG, Donald A, McHardy T, Rowlands MG, Aherne GW, Hunter LK, Taylor K, Ruddle R, Raynaud FI, Verdonk M, Workman P, Garrett MD, Collins I.
    J Med Chem; 2008 Apr 10; 51(7):2147-57. PubMed ID: 18345609
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  • 35. Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
    Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, Bauer SM, Schmidtkunz K, Wenzler S, Metzger E, Kuster B, Laufer S, Schüle R, Sippl W, Breit B, Jung M.
    Future Med Chem; 2016 Sep 10; 8(13):1537-51. PubMed ID: 27572962
    [Abstract] [Full Text] [Related]

  • 36. Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
    Barlaam B, Boiko S, Boyd S, Dry H, Gingipalli L, Ikeda T, Johnson T, Kawatkar S, Lorthioir O, Pike A, Pollard H, Read J, Su Q, Wang H, Wang H, Wang L, Wang P, Edmondson SD.
    Bioorg Med Chem Lett; 2020 Nov 15; 30(22):127523. PubMed ID: 32877741
    [Abstract] [Full Text] [Related]

  • 37. Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis.
    Moser C, Schachtschneider P, Lang SA, Gaumann A, Mori A, Zimmermann J, Schlitt HJ, Geissler EK, Stoeltzing O.
    Eur J Cancer; 2008 Jul 15; 44(11):1577-86. PubMed ID: 18445520
    [Abstract] [Full Text] [Related]

  • 38. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).
    Hawkinson JE, Sinville R, Mudaliar D, Shetty J, Ward T, Herr JC, Georg GI.
    ChemMedChem; 2017 Nov 22; 12(22):1857-1865. PubMed ID: 28952188
    [Abstract] [Full Text] [Related]

  • 39. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
    Anastassiadis T, Duong-Ly KC, Deacon SW, Lafontant A, Ma H, Devarajan K, Dunbrack RL, Wu J, Peterson JR.
    J Biol Chem; 2013 Sep 27; 288(39):28068-77. PubMed ID: 23935097
    [Abstract] [Full Text] [Related]

  • 40. Discovery of pyrrolopyrimidine inhibitors of Akt.
    Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5607-12. PubMed ID: 20810279
    [Abstract] [Full Text] [Related]

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