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Journal Abstract Search

592 related items for PubMed ID: 26974882

  • 1. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space.
    Meanwell NA.
    Chem Res Toxicol; 2016 Apr 18; 29(4):564-616. PubMed ID: 26974882
    [Abstract] [Full Text] [Related]

  • 2. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
    Meanwell NA.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1420-56. PubMed ID: 21790149
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  • 4. [Ligand efficiency and lead optimization].
    Guo ZR.
    Yao Xue Xue Bao; 2013 Dec 19; 48(12):1755-62. PubMed ID: 24689231
    [Abstract] [Full Text] [Related]

  • 5. The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations.
    Shultz MD.
    Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5992-6000. PubMed ID: 24054120
    [Abstract] [Full Text] [Related]

  • 6. The influence of lipophilicity in drug discovery and design.
    Arnott JA, Planey SL.
    Expert Opin Drug Discov; 2012 Oct 01; 7(10):863-75. PubMed ID: 22992175
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  • 7. The impact of physicochemical and molecular properties in drug design: navigation in the "drug-like" chemical space.
    Vallianatou T, Giaginis C, Tsantili-Kakoulidou A.
    Adv Exp Med Biol; 2015 Oct 01; 822():187-94. PubMed ID: 25416989
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  • 8. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
    Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1345-410. PubMed ID: 21702456
    [Abstract] [Full Text] [Related]

  • 9. Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective.
    Cavalluzzi MM, Mangiatordi GF, Nicolotti O, Lentini G.
    Expert Opin Drug Discov; 2017 Nov 19; 12(11):1087-1104. PubMed ID: 28814111
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  • 11. Improving compound quality through in vitro and in silico physicochemical profiling.
    van de Waterbeemd H.
    Chem Biodivers; 2009 Nov 19; 6(11):1760-6. PubMed ID: 19937820
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  • 13. Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters.
    Shultz MD.
    Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5980-91. PubMed ID: 24018190
    [Abstract] [Full Text] [Related]

  • 14. Hydration properties of ligands and drugs in protein binding sites: tightly-bound, bridging water molecules and their effects and consequences on molecular design strategies.
    García-Sosa AT.
    J Chem Inf Model; 2013 Jun 24; 53(6):1388-405. PubMed ID: 23662606
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  • 17. Successful generation of structural information for fragment-based drug discovery.
    Öster L, Tapani S, Xue Y, Käck H.
    Drug Discov Today; 2015 Sep 24; 20(9):1104-11. PubMed ID: 25931264
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  • 20. A new paradigm for navigating compound property related drug attrition.
    Barton P, Riley RJ.
    Drug Discov Today; 2016 Jan 24; 21(1):72-81. PubMed ID: 26404453
    [Abstract] [Full Text] [Related]

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