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Journal Abstract Search

283 related items for PubMed ID: 26976213

  • 1. Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.
    Christopeit T, Leiros HK.
    Bioorg Med Chem Lett; 2016 Apr 15; 26(8):1973-7. PubMed ID: 26976213
    [Abstract] [Full Text] [Related]

  • 2. Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening.
    Christopeit T, Carlsen TJ, Helland R, Leiros HK.
    J Med Chem; 2015 Nov 12; 58(21):8671-82. PubMed ID: 26477515
    [Abstract] [Full Text] [Related]

  • 3. Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.
    Christopeit T, Albert A, Leiros HS.
    Bioorg Med Chem; 2016 Jul 01; 24(13):2947-2953. PubMed ID: 27184103
    [Abstract] [Full Text] [Related]

  • 4. Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.
    Brindisi M, Brogi S, Giovani S, Gemma S, Lamponi S, De Luca F, Novellino E, Campiani G, Docquier JD, Butini S.
    J Enzyme Inhib Med Chem; 2016 Jul 01; 31(sup1):98-109. PubMed ID: 27121013
    [Abstract] [Full Text] [Related]

  • 5. ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.
    Liu S, Jing L, Yu ZJ, Wu C, Zheng Y, Zhang E, Chen Q, Yu Y, Guo L, Wu Y, Li GB.
    Eur J Med Chem; 2018 Feb 10; 145():649-660. PubMed ID: 29353720
    [Abstract] [Full Text] [Related]

  • 6. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.
    Muhammad Z, Skagseth S, Boomgaren M, Akhter S, Fröhlich C, Ismael A, Christopeit T, Bayer A, Leiros HS.
    Bioorg Med Chem; 2020 Aug 01; 28(15):115598. PubMed ID: 32631568
    [Abstract] [Full Text] [Related]

  • 7. Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening.
    Lund BA, Christopeit T, Guttormsen Y, Bayer A, Leiros HK.
    J Med Chem; 2016 Jun 09; 59(11):5542-54. PubMed ID: 27165692
    [Abstract] [Full Text] [Related]

  • 8. Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.
    Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW.
    ACS Infect Dis; 2018 Feb 09; 4(2):135-145. PubMed ID: 29091730
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance.
    Zhang J, Wang S, Wei Q, Guo Q, Bai Y, Yang S, Song F, Zhang L, Lei X.
    Bioorg Med Chem; 2017 Oct 01; 25(19):5133-5141. PubMed ID: 28784300
    [Abstract] [Full Text] [Related]

  • 10. In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
    Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.
    J Med Chem; 2018 Feb 08; 61(3):1255-1260. PubMed ID: 29271657
    [Abstract] [Full Text] [Related]

  • 11. A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors.
    Caburet J, Boucherle B, Bourdillon S, Simoncelli G, Verdirosa F, Docquier JD, Moreau Y, Krimm I, Crouzy S, Peuchmaur M.
    Eur J Med Chem; 2022 Oct 05; 240():114599. PubMed ID: 35841882
    [Abstract] [Full Text] [Related]

  • 12. Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.
    Skagseth S, Akhter S, Paulsen MH, Muhammad Z, Lauksund S, Samuelsen Ø, Leiros HS, Bayer A.
    Eur J Med Chem; 2017 Jul 28; 135():159-173. PubMed ID: 28445786
    [Abstract] [Full Text] [Related]

  • 13. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
    Ma G, Wang S, Wu K, Zhang W, Ahmad A, Hao Q, Lei X, Zhang H.
    Bioorg Med Chem; 2021 Jan 01; 29():115902. PubMed ID: 33302045
    [Abstract] [Full Text] [Related]

  • 14. 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.
    Legru A, Verdirosa F, Hernandez JF, Tassone G, Sannio F, Benvenuti M, Conde PA, Bossis G, Thomas CA, Crowder MW, Dillenberger M, Becker K, Pozzi C, Mangani S, Docquier JD, Gavara L.
    Eur J Med Chem; 2021 Dec 15; 226():113873. PubMed ID: 34626878
    [Abstract] [Full Text] [Related]

  • 15. Probing metallo-β-lactamases with molecular fragments identified by consensus docking.
    Klingler FM, Moser D, Büttner D, Wichelhaus TA, Löhr F, Dötsch V, Proschak E.
    Bioorg Med Chem Lett; 2015 Nov 15; 25(22):5243-6. PubMed ID: 26463134
    [Abstract] [Full Text] [Related]

  • 16. Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1).
    Nagulapalli Venkata KC, Ellebrecht M, Tripathi SK.
    Eur J Med Chem; 2021 Dec 05; 225():113747. PubMed ID: 34391033
    [Abstract] [Full Text] [Related]

  • 17. H2dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.
    Chen F, Bai M, Liu W, Kong H, Zhang T, Yao H, Zhang E, Du J, Qin S.
    Eur J Med Chem; 2021 Nov 15; 224():113702. PubMed ID: 34303873
    [Abstract] [Full Text] [Related]

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