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Journal Abstract Search

134 related items for PubMed ID: 2703405

  • 21. In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.
    Costa AK, Baker MA, Brown JM, Trudell JR.
    Cancer Res; 1989 Feb 15; 49(4):925-9. PubMed ID: 2912562
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  • 22. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    Org Biomol Chem; 2005 Jun 07; 3(11):2167-74. PubMed ID: 15917906
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  • 23. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
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  • 24. Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.
    Minchinton AI, Brown JM.
    Br J Cancer; 1992 Dec 15; 66(6):1053-8. PubMed ID: 1457345
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  • 25. Aerobic radiosensitization by SR 4233 in vitro and in vivo.
    Zeman EM, Lemmon MJ, Brown JM.
    Int J Radiat Oncol Biol Phys; 1990 Jan 15; 18(1):125-32. PubMed ID: 2298615
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  • 26. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233.
    Giaccia AJ, Biedermann KA, Tosto LM, Minchinton AI, Kovacs MS, Brown JM.
    Int J Radiat Oncol Biol Phys; 1992 Jan 15; 22(4):681-4. PubMed ID: 1544836
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  • 27. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 28. Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractionated irradiation.
    Shibata T, Shibamoto Y, Sasai K, Oya N, Murata R, Takagi T, Hiraoka M, Abe M.
    Jpn J Cancer Res; 1996 Jan 12; 87(1):98-104. PubMed ID: 8609056
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  • 29. Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides. 2.
    Monge A, Martínez-Crespo FJ, López de Ceráin A, Palop JA, Narro S, Senador V, Marín A, Sainz Y, González M, Hamilton E.
    J Med Chem; 1995 Oct 27; 38(22):4488-94. PubMed ID: 7473576
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  • 31. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF, Shinde SS, Hay MP, Denny WA.
    J Am Chem Soc; 2006 Jan 11; 128(1):245-9. PubMed ID: 16390153
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  • 38. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
    Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2004 Jan 15; 47(2):475-88. PubMed ID: 14711317
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  • 39. Bioreductive metabolism of SR-4233 (WIN 59075) by whole cell suspensions under aerobic and hypoxic conditions: role of the pentose cycle and implications for the mechanism of cytotoxicity observed in air.
    Tuttle SW, Hazard L, Koch CJ, Mitchell JB, Coleman CN, Biaglow JE.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):357-62. PubMed ID: 8195033
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  • 40. Dual action of tirapazamine in the induction of DNA strand breaks.
    Jones GD, Weinfeld M.
    Cancer Res; 1996 Apr 01; 56(7):1584-90. PubMed ID: 8603406
    [Abstract] [Full Text] [Related]

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