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Journal Abstract Search

414 related items for PubMed ID: 27064279

  • 1. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
    Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C.
    J Clin Invest; 2016 May 02; 126(5):1815-33. PubMed ID: 27064279
    [Abstract] [Full Text] [Related]

  • 2. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
    Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC.
    Neuron; 2006 Jul 06; 51(1):29-42. PubMed ID: 16815330
    [Abstract] [Full Text] [Related]

  • 3. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
    Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC.
    Alzheimers Dement; 2021 Feb 06; 17(2):271-292. PubMed ID: 32975365
    [Abstract] [Full Text] [Related]

  • 4. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
    Shen R, Zhao X, He L, Ding Y, Xu W, Lin S, Fang S, Yang W, Sung K, Spencer B, Rissman RA, Lei M, Ding J, Wu C.
    Transl Neurodegener; 2020 Jun 18; 9(1):26. PubMed ID: 32552912
    [Abstract] [Full Text] [Related]

  • 5. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.
    Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA.
    Mol Psychiatry; 2016 May 18; 21(5):707-16. PubMed ID: 26194181
    [Abstract] [Full Text] [Related]

  • 6. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
    Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA.
    J Neurosci; 2003 Jul 30; 23(17):6788-92. PubMed ID: 12890772
    [Abstract] [Full Text] [Related]

  • 7. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
    Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA.
    Neurobiol Aging; 2016 Mar 30; 39():90-8. PubMed ID: 26923405
    [Abstract] [Full Text] [Related]

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  • 9. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
    Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA.
    Am J Pathol; 2000 Jul 30; 157(1):277-86. PubMed ID: 10880397
    [Abstract] [Full Text] [Related]

  • 10. Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.
    Laifenfeld D, Patzek LJ, McPhie DL, Chen Y, Levites Y, Cataldo AM, Neve RL.
    J Neurosci; 2007 Jul 04; 27(27):7141-53. PubMed ID: 17611268
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  • 13. Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
    Jiang Y, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Cuervo AM, Nixon RA.
    J Neurosci; 2019 Jul 03; 39(27):5255-5268. PubMed ID: 31043483
    [Abstract] [Full Text] [Related]

  • 14. ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75NTR and induction of amyloid precursor protein.
    Dasgupta S, Pandya MA, Zanin JP, Liu T, Sun Q, Li H, Friedman WJ.
    Sci Signal; 2024 Sep 24; 17(855):eadn2616. PubMed ID: 39316663
    [Abstract] [Full Text] [Related]

  • 15. The Nerve Growth Factor Metabolic Pathway Dysregulation as Cause of Alzheimer's Cholinergic Atrophy.
    Do Carmo S, Kannel B, Cuello AC.
    Cells; 2021 Dec 22; 11(1):. PubMed ID: 35011577
    [Abstract] [Full Text] [Related]

  • 16. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
    Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA.
    Proc Natl Acad Sci U S A; 2010 Jan 26; 107(4):1630-5. PubMed ID: 20080541
    [Abstract] [Full Text] [Related]

  • 17. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
    Shaw JL, Chang KT.
    PLoS Genet; 2013 Jan 26; 9(9):e1003792. PubMed ID: 24086147
    [Abstract] [Full Text] [Related]

  • 18. NGF and the Amyloid Precursor Protein in Alzheimer's Disease: From Molecular Players to Neuronal Circuits.
    Triaca V, Ruberti F, Canu N.
    Adv Exp Med Biol; 2021 Jan 26; 1331():145-165. PubMed ID: 34453297
    [Abstract] [Full Text] [Related]

  • 19. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
    Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA.
    Cell Rep; 2020 Nov 24; 33(8):108420. PubMed ID: 33238112
    [Abstract] [Full Text] [Related]

  • 20. Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
    Gautier MK, Kelley CM, Lee SH, Mufson EJ, Ginsberg SD.
    Neurobiol Aging; 2024 Dec 24; 144():30-42. PubMed ID: 39265450
    [Abstract] [Full Text] [Related]

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