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143 related items for PubMed ID: 2715729

  • 1. Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.
    Kim HS, Wilson WK, Needleman DH, Pinkerton FD, Wilson DK, Quiocho FA, Schroepfer GJ.
    J Lipid Res; 1989 Feb; 30(2):247-61. PubMed ID: 2715729
    [Abstract] [Full Text] [Related]

  • 2. Enzymatic formation and chemical synthesis of an active metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism.
    Schroepfer GJ, Kim HS, Vermilion JL, Stephens TW, Pinkerton FD, Needleman DH, Wilson WK, St Pyrek J.
    Biochem Biophys Res Commun; 1988 Feb 29; 151(1):130-6. PubMed ID: 3348769
    [Abstract] [Full Text] [Related]

  • 3. Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl ester transfer protein.
    Kim HS, Oh SH, Kim DI, Kim IC, Cho KH, Park YB.
    Bioorg Med Chem; 1995 Apr 29; 3(4):367-74. PubMed ID: 8581419
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Siddiqui AU, Wilson WK, Ruecker KE, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Nov 29; 63(1-2):77-90. PubMed ID: 1486662
    [Abstract] [Full Text] [Related]

  • 5. Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Swaminathan S, Wilson WK, Pinkerton FD, Gerst N, Ramser M, Schroepfer GJ.
    J Lipid Res; 1993 Oct 29; 34(10):1805-23. PubMed ID: 8245728
    [Abstract] [Full Text] [Related]

  • 6. Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Schroepfer GJ, Parish EJ, Tsuda M, Kandutsch AA.
    Chem Phys Lipids; 1988 Jul 29; 47(3):187-207. PubMed ID: 3168085
    [Abstract] [Full Text] [Related]

  • 7. Sterol synthesis. Synthesis of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluorocholest-5-en-7-one and its effects on HMG-CoA reductase activity in Chinese hamster ovary cells, on ACAT activity in rat jejunal microsomes, and serum cholesterol levels in rats.
    Carroll JN, Pinkerton FD, Su X, Gerst N, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1998 Aug 29; 94(2):209-25. PubMed ID: 9779586
    [Abstract] [Full Text] [Related]

  • 8. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5 alpha-cholest-8(14)-ene-3 beta,15 beta,26-triol, a potential metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1992 May 29; 61(3):235-42. PubMed ID: 1525963
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Numazawa S, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Oct 29; 33(10):1503-15. PubMed ID: 1431575
    [Abstract] [Full Text] [Related]

  • 10. Inhibitors of sterol synthesis. An improved chemical synthesis of 26-oxygenated delta 8(14)-15-ketosterols having the 25R configuration.
    Siddiqui AU, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1994 May 23; 71(2):205-18. PubMed ID: 8076403
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of sterol synthesis. Chemical synthesis of 7 alpha-ethyl and 16 alpha-ethyl derivatives of delta 8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells.
    Kim HS, Wilson WK, Kirkpatrick ND, Pinkerton FD, Swaminathan S, Hylarides MD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Jul 23; 62(1):55-67. PubMed ID: 1423803
    [Abstract] [Full Text] [Related]

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  • 13. Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols.
    Schroepfer GJ, Parish EJ, Kandutsch AA.
    Chem Phys Lipids; 1988 Feb 23; 46(2):147-54. PubMed ID: 3342458
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of sterol synthesis. Differential effects of 14 alpha-hydroxymethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol and 14 alpha-hydroxymethyl-5 alpha-cholest-6-ene-3 beta, 15 alpha-diol on sterol synthesis in cell-free homogenates of rat liver.
    Miller LR, Pascal RA, Schroepfer GJ.
    J Biol Chem; 1981 Aug 10; 256(15):8085-91. PubMed ID: 7263642
    [Abstract] [Full Text] [Related]

  • 15. Sterol synthesis. Preparation and characterization of fluorinated and deuterated analogs of oxygenated derivatives of cholesterol.
    Li S, Pang J, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1999 May 10; 99(1):33-71. PubMed ID: 10377963
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats.
    Swaminathan S, Siddiqui AU, Gerst N, Pinkerton FD, Kisic A, Kim LJ, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1995 Apr 10; 36(4):767-86. PubMed ID: 7616123
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  • 18. Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol.
    Herz JE, Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Apr 10; 33(4):579-98. PubMed ID: 1527481
    [Abstract] [Full Text] [Related]

  • 19. Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Siddiqui AU, Swaminathan S, Pinkerton FD, Gerst N, Wilson WK, Choi H, Schroephfer GJ.
    Chem Phys Lipids; 1994 Jun 24; 72(1):59-75. PubMed ID: 7923480
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